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Elevated serum neurofilament light chain levels are associated with hepatic encephalopathy in patients with cirrhosis
Increasing evidences implicate vital role of neuronal damage in the development of hepatic encephalopathy (HE). Neurofilament light chain (NfL) is...
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Recent advances in nanomaterials for the treatment of femoral head necrosis
Osteonecrosis of the femoral head (ONFH) is a condition that causes considerable pain and discomfort for patients, and its pathogenic mechanisms are...
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An analysis of the role of GAB2 in pan-cancer from a multidimensional perspective
BackgroundTo explore the role of GAB2 in pan-cancer based on bioinformatics analysis.
MethodsBased on TCGA and GTEx databases, we used TIMER2.0...
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Elevated Metal Levels in U.S. Honeys: Is There a Concern for Human Health?
Honey is a bioactive food used for millennia to improve health and treat diseases. More recently, researchers employ honey as a tool to assess local...
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Contribution of plasma levels of VEGF-A and angiopoietin-2 in addition to a genetic variant in KCNAB1 to predict the risk of bevacizumab-induced hypertension
Bevacizumab-induced hypertension poses a therapeutic challenge and identifying biomarkers for hypertension can enhance therapy safety. Lower plasma...
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PTBP1 protects Y RNA from cleavage leading to its apoptosis-specific degradation
Some RNAs such as 28S rRNA, U1 small nuclear RNA (snRNA), and Y RNAs are known to be cleaved during apoptosis. The underlying mechanism, functions,...
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Nomogram for predicting the probability of rectal anastomotic re-leakage after stoma closure: a retrospective study
BackgroundIn this study, we aimed to identify the risk factors in patients with rectal anastomotic re-leakage and develop a prediction model to...
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The diagnostic and prognostic value of tartrate-resistant acid phosphatase isoform 5b for giant cell tumor of bone
BackgroundSerum level of tartrate-resistant acid phosphatase 5b (TRACP5b) is an excellent serum marker of bone resorption. In patients with giant...
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Correlation Between Severity of Schizophrenia with Certain Trace Elements and TNF-α Gene Expression and Its Circulatory Level in the Population of Western India
This cross-sectional study aimed to assess serum trace element (TE) concentrations, TNF-α gene expression, protein levels in schizophrenia (SZ)...
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Polycomb function in early mouse development
Epigenetic factors are crucial for ensuring proper chromatin dynamics during the initial stages of embryo development. Among these factors, the...
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Introduction and impact of routine whole genome sequencing in the diagnosis and management of sarcoma
BackgroundSarcomas are diverse neoplasms with highly variable histological appearances in which diagnosis is often challenging and management options...
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Enhanced γ-H2AX Foci Frequency and Altered Gene Expression in Participants Exposed to Ionizing Radiation During I-131 Nuclear Medicine Procedures
PurposeIonizing radiation-based technologies are extensively used in the diagnosis and treatment of diseases. While utilizing the technologies,...
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Rare case of myelodysplastic syndrome with excess blasts 2 develo** after adjuvant chemoradiotherapy for triple-negative breast cancer in a patient with Bloom syndrome
IntroductionBloom syndrome (BS) is a rare autosomal recessive disorder caused by a loss-of-function mutation in the BLM gene encoding an RecQ...
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Presence of Fusobacterium nucleatum in relation to patient survival and an acidic environment in oesophagogastric junction and gastric cancers
BackgroundFusobacterium nucleatum inhabits the oral cavity and affects the progression of gastrointestinal cancer. Our prior findings link F....
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A Modified Floxuridine Reduced-Dose Protocol for Patients with Unresectable Colorectal Liver Metastases Treated with Hepatic Arterial Infusion
BackgroundMost patients treated with the standard dosing protocol (SDP) of hepatic arterial infusion (HAI) floxuridine require dose holds and...
