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Progesterone regulates tissue non-specific alkaline phosphatase (TNSALP) expression and activity in ovine utero-placental tissues
BackgroundTissue non-specific alkaline phosphatase (TNSALP; encoded by the ALPL gene) has a critical role in the postnatal regulation of phosphate...
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Homopolymer switches mediate adaptive mutability in mismatch repair-deficient colorectal cancer
Mismatch repair (MMR)-deficient cancer evolves through the stepwise erosion of coding homopolymers in target genes. Curiously, the MMR genes MutS...
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Brown trout in Oder estuary tributaries: genetic structure, stocking, and admixture
Several rivers that are tributaries of the Oder estuary are inhabited by Salmo trutta L, the most important of which are Ina, Gowienica, and...
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Metabolomic and transcriptomic analyses of peach leaves and fruits in response to pruning
BackgroundPruning is an important cultivation management option that has important effects on peach yield and quality. However, the effects of...
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Level of Awareness and Willingness to Pay for Safe Milk: A Study of Urban Consumers in North India
Milk adulteration and contamination pose a serious challenge for the dairy sector. Consumer awareness of food safety can be crucial in addressing...
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Genome-wide identification and molecular evolution of Dof transcription factors in Cyperus esculentus
Dof transcription factor family in Cyperus esculentus genome was identified and analyzed using bioinformatics. The analysis results revealed that C.esculentus...
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Blackberry synthetic seeds storage: effects of temperature, time, and sowing substrate
In vitro propagation, is becoming the predominant method for blackberry propagation due to its advantages compared to agamic traditional propagation...
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High-dimensional multi-omics measured in controlled conditions are useful for maize platform and field trait predictions
Key messageTranscriptomics and proteomics information collected on a platform can predict additive and non-additive effects for platform traits and...
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Constraints on the subsecond modulation of striatal dynamics by physiological dopamine signaling
Dopaminergic neurons play a crucial role in associative learning, but their capacity to regulate behavior on subsecond timescales remains debated. It...
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SETDB1 regulates short interspersed nuclear elements and chromatin loop organization in mouse neural precursor cells
BackgroundTransposable elements play a critical role in maintaining genome architecture during neurodevelopment. Short Interspersed Nuclear Elements...
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Ecological genetics of isolated loach populations indicate compromised adaptive potential
Many endangered species live in fragmented and isolated populations with low genetic variability, signs of inbreeding, and small effective population...
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Systematic characterization of immunoglobulin loci and deep sequencing of the expressed repertoire in the Atlantic cod (Gadus morhua)
BackgroundThe Atlantic cod is a prolific species in the Atlantic, despite its inconsistent specific antibody response. It presents a peculiar case...
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Key gene modules and hub genes associated with pyrethroid and organophosphate resistance in Anopheles mosquitoes: a systems biology approach
Indoor residual spraying (IRS) and insecticide-treated nets (ITNs) are the main methods used to control mosquito populations for malaria prevention....
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Development of pre-implantation genetic testing protocol for monogenic disorders (PGT-M) of Hb H disease
Hb H disease is the most severe form of α-thalassemia compatible with post-natal life. Compound heterozygous α 0 -thalassemia − SEA deletion/α + -thalassemia...
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Characterization and arbovirus susceptibility of cultured CERNI cells derived from sika deer (Cervus nippon)
Cervus nippon (sika deer) are widely distributed throughout eastern Asia. Deer possess a variety of antibodies against several zoonotic pathogens,...
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A feature-specific prediction error model explains dopaminergic heterogeneity
The hypothesis that midbrain dopamine (DA) neurons broadcast a reward prediction error (RPE) is among the great successes of computational...
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Gut microbiota DPP4-like enzymes are increased in type-2 diabetes and contribute to incretin inactivation
BackgroundThe gut microbiota controls broad aspects of human metabolism and feeding behavior, but the basis for this control remains largely unclear....
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Post-Conflict Behaviors of Wild Gelada Monkeys (Theropithecus gelada) at Guassa, Ethiopia
Post-conflict behaviors are a crucial component of primate sociality, yet are difficult to study in the wild. We evaluated the presence and timing of...
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A comparison of the TempO-Seq and Affymetrix microarray platform using RTqPCR validation
Next-generation risk assessment relies on mechanistic data from new approach methods, including transcriptome data. Various technologies, such as...
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Potential of advanced genome editing tools in plant biotechnology and crop improvement: progress and challenges
Climate change has made plants more vulnerable to various stresses, which presents a significant threat to the world’s food supply. Despite several...
