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(Re)Emerging disease and conflict risk in Africa, 1997–2019
While the number of infectious zoonotic disease outbreaks has been rising, their impact on civil war and social conflict is poorly understood. This...
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Unlocking opioid neuropeptide dynamics with genetically encoded biosensors
Neuropeptides are ubiquitous in the nervous system. Research into neuropeptides has been limited by a lack of experimental tools that allow for the...
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Caloric and time restriction diets improve acute kidney injury in experimental menopausal rats: role of silent information regulator 2 homolog 1 and transforming growth factor beta 1
BackgroundEstrogen has a protective impact on acute kidney injury (AKI); moreover, reducing the daily intake of calories impedes develo** diseases....
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Unravelling heterogeneous malaria transmission dynamics in the Peruvian Amazon: insights from a cross-sectional survey
BackgroundMalaria remains a global health challenge, particularly in Peru's Loreto region. Despite ongoing efforts, high infection rates and...
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Prevalence and correlates of common mental disorders among participants of the Uganda Genome Resource: Opportunities for psychiatric genetics research
Genetics research has potential to alleviate the burden of mental disorders in low- and middle-income-countries through identification of new...
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PET imaging of neuroinflammation: any credible alternatives to TSPO yet?
Over the last decades, the role of neuroinflammation in neuropsychiatric conditions has attracted an exponentially growing interest. A key driver for...
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The role of quercetin in ameliorating bleomycin-induced pulmonary fibrosis: insights into autophagy and the SIRT1/AMPK signaling pathway
BackgroundIdiopathic pulmonary fibrosis (IPF) is a disease of unknown etiology characterized by a constant incidence rate. Unfortunately, effective...
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A biochemical assessment of apoptosis-inducing impact of Salinomycin in combination with ciprofloxacin on human leukemia KG1–a stem-like cells in the presence and absence of insulin
BackgroundAcute Myeloid Leukemia (AML) is a fast-develo** invading cancer that impacts the blood and bone marrow, marked by the rapid proliferation...
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Synthetic Alfalfa Infusion Odour Attracts Gravid Culex quinquefasciatus Under Laboratory Conditions
Gravid culicine mosquitoes rely on olfactory cues for selecting breeding sites containing organic detritus. While this capacity of the mosquitoes is...
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Advances in development of biomarkers for brain damage and ischemia
Acquired brain injury is an urgent situation that requires rapid diagnosis and treatment. Magnetic resonance imaging (MRI) and computed tomography...
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Where do Harris’ Checkerspots Lay their Eggs and what are the Consequences?
Where a female lays her eggs has strong implications for the survival of her offspring, an impetus that takes on particular significance for species...
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Evaluation of the Irrigation Water Quality of Beressa River, North West Ethiopia
Beressa River is facing a problem due to uncontrolled discharge of liquid wastes from domestics and industries. Therefore, the study was conducted to...
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A bipolar disorder-associated missense variant alters adenylyl cyclase 2 activity and promotes mania-like behavior
The single nucleotide polymorphism rs13166360, causing a substitution of valine (Val) 147 to leucine (Leu) in the adenylyl cyclase 2 (ADCY2), has...
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Multiplex PCR-based genoty** of Salmonella Enteritidis and Salmonella Typhimurium from food sources and assessment of their antimicrobial resistance profiles in Egypt
BackgroundSalmonellosis is a widespread zoonotic disease that poses a significant threat to livestock and public health. This study aimed to serotype...
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Immunodetection of tubulin and centromeric histone H3 (CENH3) proteins in Glycine species
BackgroundThe centromeres appear as primary constrictions on monocentric metaphase chromosomes; where sister chromatids are held together and...
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Association of histidine-rich glycoprotein C633T single nucleotide polymorphism and recurrent miscarriage in Iranian women
BackgroundRecurrent miscarriage (RM) is defined as the occurrence of at least two or three subsequent miscarriages within the 20th -24th weeks of...
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The C-terminal region of the Plasmodium berghei gamete surface 184-kDa protein Pb184 contributes to fertilization and male gamete binding to the residual body
BackgroundMalaria, a global health concern, is caused by parasites of the Plasmodium genus, which undergo gametogenesis in the midgut of mosquitoes...
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Up-regulation of miR-126 via DNA methylation in hypoxia-preconditioned endothelial cells may contribute to hypoxic tolerance of neuronal cells
BackgroundEndothelial cells (ECs) can confer neuroprotection by secreting molecules. This study aimed to investigate whether DNA methylation...
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Suppression of CTC1 inhibits hepatocellular carcinoma cell growth and enhances RHPS4 cytotoxicity
BackgroundAlthough DNA repair mechanisms function to maintain genomic integrity, in cancer cells these mechanisms may negatively affect treatment...
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Loop-mediated isothermal amplification (LAMP) assay for early on-site detection of Group B Streptococcus infection in neonatal sepsis blood sample
BackgroundNeonatal sepsis, often attributed to Group B Streptococcus (GBS) infection, poses a critical health risk to infants, demanding rapid and...
