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Altered RNA export by SF3B1 mutants confers sensitivity to nuclear export inhibition
SF3B1 mutations frequently occur in cancer yet lack targeted therapies. Clinical trials of XPO1 inhibitors, selinexor and eltanexor, in high-risk...
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Death anxiety among caregivers of patients with advanced cancer: a cross-sectional survey
PurposeThis study aimed to investigate death anxiety (DA) in caregivers of patients with advanced cancer and identify associated factors in the...
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Predictive enrichment for the need of renal replacement in sepsis-associated acute kidney injury: combination of furosemide stress test and urinary biomarkers TIMP-2 and IGFBP-7
BackgroundIn sepsis, initial resuscitation with fluids is followed by efforts to achieve a negative fluid balance. However, patients with...
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Heart rate variability as a predictor of intraoperative autonomic nervous system homeostasis
The aim of the proof-of-concept study is to investigate the level of concordance between the heart rate variability (HRV), the EEG-based Narcotrend...
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Association of oral mucositis induced by anthracycline-cyclophosphamide and subsequent docetaxel treatment for perioperative breast cancer
PurposeAnthracycline-cyclophosphamide followed by docetaxel-containing chemotherapy is effective for perioperative breast cancer treatment. However,...
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Enhancing sepsis biomarker development: key considerations from public and private perspectives
Implementation of biomarkers in sepsis and septic shock in emergency situations, remains highly challenging. This viewpoint arose from a...
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Consensus-building to improve implementation of NICE guidance on planning for end-of-life treatment and care: a mixed-methods study
BackgroundDespite the availability of guidance for the provision of good end-of-life care, there are significant variations across the UK in its...
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Differences in severity of chemotherapy-induced nausea and vomiting between neoadjuvant and adjuvant chemotherapy in patients with breast cancer: analysis of data from two prospective observational studies
PurposeWe assessed the differences in chemotherapy-induced nausea and vomiting (CINV) severity in patients with breast cancer, receiving neoadjuvant...
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Magnitude of emergence agitation, its interventions and associated factors among paediatric surgical patients
BackgroundEmergence agitation is a transient confusional state of a child associated with consciousness from general anaesthesia, commonly occurs in...
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Targeting CERS6-AS1/FGFR1 axis as synthetic vulnerability to constrain stromal cells supported proliferation in Mantle cell lymphoma
The interaction between stromal and tumor cells in tumor microenvironment is a crucial factor in Mantle cell lymphoma (MCL) progression and therapy...
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Changes in skeletal muscle function during chemotherapy and related factors in patients with acute leukemia
IntroductionSkeletal muscle function is an important prognostically relevant indicator in patients with acute leukemia (AL), but skeletal dysfunction...
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Specialized expertise among healthcare professionals in palliative care - A sco** review
BackgroundThe generalist-plus-specialist palliative care model is endorsed worldwide. In the Netherlands, the competencies and profile of the...
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Glucagon-like peptide-1 (GLP-1) receptor agonists for headache and pain disorders: a systematic review
BackgroundGlucagon-like peptide-1 (GLP-1) plays a crucial role in metabolic disorders by enhancing insulin secretion, inhibiting glucagon release,...
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Beneficial Effect of Pretreatment Hyperosmolality on Outcome in Severe Traumatic Brain Injury: Evidence from a South Korean Multicenter Registry and Propensity Score Matching Analysis
BackgroundHyperosmolar therapy has long been a cornerstone in managing increased intracranial pressure and improving outcomes in severe traumatic...
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The role of upper airway ultrasonography in tracheal necrosis diagnosis: a case report
BackgroundTracheal necrosis post endotracheal intubation is a rare life-threatening disease that can compromise airway patency. We demonstrated a...
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Patient attitudes and experiences towards exercise during oncological treatment. A qualitative systematic review
PurposeExercise and physical activity (PA) during oncological treatment have many benefits. However, PA levels and adherence are often low. This...
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An elderly case of paraneoplastic anti-NMDA receptor encephalitis associated with large cell neuroendocrine carcinoma of the lung
BackgroundRecent studies have suggested that N-methyl-D-aspartate (NMDA) receptors are involved in the cell proliferation in several tumors. However,...
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Trace of delirium after robotic lower abdominal tumor resection at different end-tidal carbon dioxide: a RCT trial
BackgroundPostoperative delirium (POD) often occurs in oncology patients, further increasing the medical and financial burden. Robotic technology in...
