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A Longitudinal Analysis of the Relationship Between Different Levels of Cognitively Stimulating Leisure Activity and Cognitive Function Among Older Adults with MCI
The aim of this study was to examine the longitudinal relationship between different levels of cognitively stimulating leisure activity (CSLA)...
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Persistent sodium currents in neurons: potential mechanisms and pharmacological blockers
Persistent sodium current (I NaP ) is an important activity-dependent regulator of neuronal excitability. It is involved in a variety of physiological...
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Single-cell transcriptomic profiling of human pancreatic islets reveals genes responsive to glucose exposure over 24 h
Aims/hypothesisDisruption of pancreatic islet function and glucose homeostasis can lead to the development of sustained hyperglycaemia, beta cell...
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Trajectories of BMI before and after diagnosis of type 2 diabetes in a real-world population
Aims/hypothesisFew studies have examined the clinical characteristics associated with changes in weight before and after diagnosis of type 2...
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The use of transcutaneous electrical acupoint stimulation to reduce opioid consumption in patients undergoing off-pump CABG: a randomized controlled trial
BackgroundHigh doses of long-acting opioids were used to facilitate off-pump coronary artery bypass grafting procedure, which may result in...
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Higher fibre and lower carbohydrate intake are associated with favourable CGM metrics in a cross-sectional cohort of 470 individuals with type 1 diabetes
Aims/hypothesisThe aim of this work was to investigate the association between macronutrient intakes and continuous glucose monitoring (CGM) metrics...
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An integrated clinical approach to children at genetic risk for neurodevelopmental and psychiatric conditions: interdisciplinary collaboration and research infrastructure
BackgroundA sizeable proportion of pathogenic genetic variants identified in young children tested for congenital differences are associated with...
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Multiple ultradian rhythms of metabolism, body temperature and activity in Djungarian hamsters
Djungarian hamsters (Phodopus sungorus) living at constant 15 °C T a in short photoperiod (8:16 h L:D) showed pronounced ultradian rhythms (URs) of...
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Technology advances in diabetes pregnancy: right technology, right person, right time
This review outlines some of the extraordinary recent advances in diabetes technology, which are transforming the management of type 1 diabetes...
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Enhanced deep leaning model for detection and grading of lumbar disc herniation from MRI
Lumbar disc herniation is one of the most prevalent orthopedic issues in clinical practice. The lumbar spine is a crucial joint for movement and...
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Impact of medical therapy for hormone-secreting Pituitary tumors on bone
PurposeBone health is often impaired in patients with hormone-secreting pituitary tumors. Since medical therapy is central to their care,...
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Pituitary surgery and COVID
An effect of the COVID-19 pandemic was the disruption of healthcare systems, especially surgical services provided to the community. Pituitary...
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tRNA-derived fragments in T lymphocyte–beta cell crosstalk and in type 1 diabetes pathogenesis in NOD mice
Aims/hypothesistRNAs play a central role in protein synthesis. Besides this canonical function, they were recently found to generate non-coding RNA...
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Impact of high-altitude hypoxia on Helicobacter pylori-induced gastritis pathological manifestations and inflammatory responses
BackgroundChronic gastritis caused by Helicobacter pylori (Hp) infection is a common gastrointestinal disorder. Despite the high prevalence of Hp...
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Temporal and masseter muscle evaluation by MRI provides information on muscle mass and quality in acromegaly patients
PurposeThe impact of GH/IGF-1 levels on skeletal muscle in acromegaly is still controversial. Temporal (TMT) and masseter muscle (MMT) thickness has...
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N-Glycosylation Deficiency in Transgene α7 nAChR and RIC3 Expressing CHO Cells Without NACHO
The human neuronal nicotinic acetylcholine receptor α7 (nAChR) is an important target implicated in diseases like Alzheimer’s or Parkinson’s, as well...
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Stretching intervention can prevent muscle injuries: a systematic review and meta-analysis
PurposePrevious meta-analysis studies concluded that static stretching intervention cannot decrease all-cause injury in healthy active individuals....
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Retroperitoneum revisited: a review of radiological literature and updated concept of retroperitoneal fascial anatomy with imaging features and correlating anatomy
PurposeSpread of disease in the retroperitoneum is dictated by the complex anatomy of retroperitoneal fasciae and is still incompletely understood....
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Characterizing the phenotypic and genetic structure of psychopathology in UK Biobank
Mental health conditions are characterized by higher-order transdiagnostic factor structures, which may contribute to the high levels of comorbidity...
