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Altered RNA export by SF3B1 mutants confers sensitivity to nuclear export inhibition
SF3B1 mutations frequently occur in cancer yet lack targeted therapies. Clinical trials of XPO1 inhibitors, selinexor and eltanexor, in high-risk...
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Dietary salt promotes cognitive impairment through repression of SIRT3/PINK1-mediated mitophagy and fission
Dietary salt is increasingly recognized as an independent risk factor for cognitive impairment. However, the exact mechanisms are not yet fully...
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Checkpoint and Coordinated Cellular Responses to DNA Damage
The DNA damage and replication checkpoints are signaling mechanisms that regulate and coordinate cellular responses to genotoxic conditions. The...
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Chemical Signalling in Beetles
This chapter reviews chemical structures of biologically active, volatile compounds in beetles. Techniques used for structure elucidation are briefly...
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Regulation of S Phase
Regulation of DNA replication is critical for accurate and timely dissemination of genomic material to daughter cells. The cell uses a variety of...
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Insect Chemical Defense
Research on the defensive chemistry of insects during the last decade is reviewed, with special emphasis on non-volatile compounds. The isolation and...
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Control of Cell Proliferation and Growth by Myc Proteins
Myc proteins act as signal transducers that alter cell proliferation in dependence on signals from the extracellular environment. In normal cells,...
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The Retinoblastoma Gene Family in Cell Cycle Regulation and Suppression of Tumorigenesis
Since its discovery in 1986, as the first tumor suppressor gene, the retinoblastoma gene (Rb) has been extensively studied. Numerous biochemical and...
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Present Status of Antifouling Systems in Japan: Tributyltin Substitutes in Japan
An international conference held by the International Maritime Organization in October 2001 adopted an “International convention on the control of...
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New Trends in Sample Preparation Methods for the Determination of Organotin Compounds in Marine Matrices
Tributyltin still remains a major issue for the marine environment and its determination is mandatory by legislation in several countries. As for...
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Development, Occurrence and Regulationof Antifouling Paint Biocides: Historical Review and Future Trends
Antifouling agents have been used on ships since the ancient Roman and Greek civilizations. A brief history is provided through to the demise of...
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Antifouling Paint Booster Biocides: Occurrence and Partitioning in Water and Sediments
Following the ban on the use of tributyltin (TBT) in antifouling, several organic booster biocides have been used in conjunction with copper in...
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Worldwide Occurrence of Organotins from Antifouling Paints and Effects in the Aquatic Environment
Organotins belong to the most toxic pollutants for aquatic life known so far. Widespread contamination of harbors and areas with high ship**...
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Senescence and Cell Cycle Control
In response to various stresses, such as telomere shortening during continuous proliferation, oxidative stress, DNA damage and aberrant oncogene...
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Transcriptome analysis in abiotic stress conditions in higher plants
Drought, high salinity, and low temperature are major environmental factors that limit plant productivity. Plants respond and adapt to these stresses...
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Signal transduction in plant cold acclimation
Temperate plants respond to low temperature by activating a cold acclimation program leading to enhanced tolerance to freezing temperatures. This...
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Plant salt tolerance
Soil salinity adversely affects crop productivity and quality. The success of breeding programs aimed at salinity tolerant crop varieties is limited...
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Plant responses to heat stress
The heat stress response is characterized by inhibition of normal transcription and translation, higher expression of heat shock proteins (hsps) and...
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Sensors of abiotic stress in Synechocystis
Systematic mutagenesis of histidine kinases in combination with DNA microarray technology has allowed us to identify sensors for cold, hyperosmotic...