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Measuring pain intensity in older patients: a comparison of five scales
Background and aimsPain is common in older individuals. In order to understand and treat pain in this group, reliable and valid measures are needed....
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Single cell transcriptome analysis identified a unique neutrophil type associated with Alzheimer’s disease
BackgroundNeutrophils play an essential role in Alzheimer’s disease (AD) pathology. However, the extent of their heterogeneity remains poorly...
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Development of machine learning models for patients in the high intrahepatic cholangiocarcinoma incidence age group
BackgroundIntrahepatic cholangiocarcinoma (ICC) has a poor prognosis and is understudied. Based on the clinical features of patients with ICC, we...
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Development of a real-world simulated instrument for evaluating visuospatial working memory: a preliminary psychometric study on older adults
BackgroundA prevalent challenge in neuropsychological assessment, particularly when utilizing instruments designed for controlled laboratory...
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A Phenomenological Analysis of Emerging Adults’ Social Group Disruptions
Emerging adults experience the highest rates of loneliness and mental health issues of any age group. Given that frequent changes to their social...
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Altered pupil light and darkness reflex and eye-blink responses in late-life depression
BackgroundLate-life depression (LLD) is a prevalent neuropsychiatric disorder in the older population. While LLD exhibits high mortality rates,...
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The impact of cognitive-motor interference on balance and gait in hearing-impaired older adults: a systematic review
BackgroundHearing impairments are a rising burden in our aging society. Hearing loss is associated with reduced cognitive performance as well as...
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Evaluation of a knowledge-attitude-practice model based narrative life education program for community-dwelling older adults: a mixed-methods feasibility study
BackgroundThe global aging population presents challenges that are particularly acute in China. Older Chinese adults’ attitudes towards death...
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Positive Childhood Experiences and Spiritual Well-Being: Psychological Flexibility and Meaning-Based Co** as Mediators in Turkish Sample
Spiritual well-being enhances life quality, acts as a stress reliever, and mitigates unfavorable feelings. It helps individuals find meaning and...
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Outcomes of home design to support healthy cognitive ageing: modified e-Delphi exercise with older people and housing-related professionals
BackgroundThere is emerging agreement that living in a home designed to support healthy cognitive ageing can enable people to live better with...
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Multi-Dimensional Healthy Aging Interventions: Evidence from an Age-Friendly Community Program in Italy
In this paper, we evaluate a pre-pandemic multi-dimensional healthy aging program promoted by an Italian private Foundation to provide new insights...
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ACTing Spiritually: Integrating Spiritual Care and Mental Health Care within a US Department of Veterans Affairs Inpatient Psychiatric Unit
As a part of the VA’s interprofessional fellowship in psychosocial rehabilitation, the authors developed an 8-week spirituality group manual, ACTing...
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Single-cell landscape of immunological responses in elderly patients with sepsis
Sepsis is a dysregulated host response to severe infections, and immune dysfunction plays a crucial role in its pathogenesis. Elderly patients, a...
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One-year mortality risk in older individuals with femoral intertrochanteric fracture: a tertiary center in China
BackgroundThe accelerated growth of older individuals worldwide has increased the number of patients presenting with fragility hip fractures. Having...
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Kinetics of pro- and anti-inflammatory spike-specific cellular immune responses in long-term care facility residents after COVID-19 mRNA primary and booster vaccination: a prospective longitudinal study in Japan
BackgroundThe magnitude and durability of cell-mediated immunity in older and severely frail individuals following coronavirus disease 2019...
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Influenza virus infection exacerbates gene expression related to neurocognitive dysfunction in brains of old mice
BackgroundAge > 65 years is a key risk factor for poor outcomes after human influenza infection. Specifically, in addition to respiratory disease,...
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Association between masticatory function, frailty, and functional disability: an observational study
BackgroundIncrease in functional disability in aging societies is an international medical and public health issue. Masticatory function may be a...
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Trends in commonly used and potentially inappropriate medications in older Korean patients with polypharmacy
BackgroundPolypharmacy is a global public health concern. This study aimed to determine the prevalence of polypharmacy and trends in the use of...
