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Development of Technetium-99m and Rhenium-188 Radiopharmaceuticals Containing a Terminal Metal–Nitrido Multiple Bond for Diagnosis and Therapy
The chemistry of nitrido complexes of technetium has played an important role in the search of new Tc-99m radiopharmaceuticals and in providing...
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Monitoring Multidrug Resistance P-Glycoprotein Drug Transport Activity with Single-Photon Emission Computed Tomography and Positron Emission Tomography Radiopharmaceuticals
Multidrug resistance (MDR) mediated by overexpression of MDR1 P-glycoprotein (Pgp) is one of the best characterized transporter-mediated barriers to...
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Radiopharmaceuticals for Positron Emission Tomography Imaging of Somatostatin Receptor Positive Tumors
The targeting of somatostatin receptors in tumors has been a goal in cancer treatment and diagnosis since the 1980s. Over the past two decades, great...
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Rhenium and Technetium Complexes Anchored by Phosphines and Scorpionates for Radiopharmaceutical Applications
This review presents a comprehensive overview of the most significant developments in the chemistry of technetium and rhenium complexes anchored by...
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6-Hydrazinonicotinamide Derivatives as Bifunctional Coupling Agents for 99mTc-Labeling of Small Biomolecules
99mTc-labeled small biomolecules are a class of receptor-based, target specific radiopharmaceuticals for the detection of various diseases, such as...
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Radiolabeled Integrin αvβ3 Antagonists as Radiopharmaceuticals for Tumor Radiotherapy
Integrins are a family of proteins that facilitate cellular adhesion to and migration on the extracellular matrix proteins found in intercellular...
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New Organometallic Technetium Complexes for Radiopharmaceutical Imaging
It is the objective of this review to introduce the reader to the current status of organometallic chemistry, oriented towards the development of...
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Microwave ablation followed by cTACE in 5-cm HCC lesions: does a single-session approach affect liver function?
PurposeMicrowave ablation (MWA) and conventional transarterial chemoembolization (cTACE) are locoregional treatments commonly performed in very...
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Deep learning-based image quality assessment: impact on detection accuracy of prostate cancer extraprostatic extension on MRI
ObjectiveTo assess impact of image quality on prostate cancer extraprostatic extension (EPE) detection on MRI using a deep learning-based AI...
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Widespread haemorrhages in infants post-shunting (WHIPS): clinical features, risk factors and neuroimaging characteristics of a rare and under-recognised phenomenon
PurposeInfants undergoing CSF shunting procedures face a rare complication which we propose to rename “Widespread Haemorrhages in Infants...
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Nuclear-Based Labeling of Cellular Immunotherapies: A Simple Protocol for Preclinical Use
Labeling and tracking existing and emerging cell-based immunotherapies using nuclear imaging is widely used to guide the preclinical phases of...
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Radiopalmar ganglion cysts: prevalence, morphology, and clinical significance in wrist MRI
ObjectivesTo assess radiopalmar ganglion cysts’ (RPG) prevalence, morphology, and clinical significance in consecutive patients.
Materials and methods ...
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Noradrenergic cardiac denervation is associated with gait velocity in Parkinson disease: a dual ligand PET study
PurposePreliminary data suggest that gait abnormalities in Parkinson disease (PD) may be associated with sympathetic cardiac denervation. No...
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Hyperechogenicity and histopathological features of focal liver lesions
The identification and accurate diagnosis of focal liver lesions are important in modern medicine, where diagnostic radiology plays an essential...
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Diagnostic MRI for deep pelvic endometriosis: towards a standardized protocol?
ObjectivesTo assess the diagnostic efficacy of an MRI protocol and patient preparation in detecting deep pelvic endometriosis (DPE).
Material and...
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Radiomics score derived from T1-w/T2-w ratio image can predict motor symptom progression in Parkinson’s disease
ObjectivesTo clarify the association between a radiomics score (Rad-score) derived from T1-weighted signal intensity to T2-weighted signal intensity...
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MRI of kidney size matters
ObjectiveTo highlight progress and opportunities of measuring kidney size with MRI, and to inspire research into resolving the remaining...
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Factors affecting radiation dose, radiation exposure time and procedural time in arterial embolization for active hemorrhage
PurposeTo evaluate patient and procedure-related factors contributing to the radiation dose, cumulative fluoroscopy time (CFT), and procedural time...
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Detectability of intracranial vessel wall atherosclerosis using black-blood spectral CT: a phantom and clinical study
BackgroundComputed tomography (CT) is the usual modality for diagnosing stroke, but conventional CT angiography reconstructions have limitations.
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Sedation-free pediatric [18F]FDG imaging on totalbody PET/CT with the assistance of artificial intelligence
PurposeWhile sedation is routinely used in pediatric PET examinations to preserve diagnostic quality, it may result in side effects and may affect...
