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Ikaros sets the threshold for negative B-cell selection by regulation of the signaling strength of the AKT pathway
Inhibitory phosphatases, such as the inositol-5-phosphatase SHIP1 could potentially contribute to B-cell acute lymphoblastic leukemia (B-ALL) by...
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The spectrum of health conditions in community-based cross-sectional surveys in Southeast Asia 2010-21: a sco** review
BackgroundSoutheast Asia is undergoing an epidemiological transition with non-communicable illnesses becoming increasingly important, yet infectious...
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Unravelling factors influencing demand for modern contraception and evaluating coverage progress since 2015 in Ethiopia, Kenya, and Nigeria: insights from multilevel and geostatistical modelling
IntroductionThe United Nations established the Sustainable Development Goals (SDGs) in 2015 to enhance global development. In this study, we examine...
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A two-pronged approach to understanding reciprocity and mental health relationship in develo** countries: evidence from young informal construction workers in Nigeria
BackgroundMental health problems disproportionately affect young people in develo** countries. However, there is limited research on help-seeking...
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Survey on pattern of myopia in school children in Hangzhou after the COVID-19 pandemic: a school-based vision screening study
BackgroundMyopia is a major health issue around the world. Myopia in children has increased significantly during the COVID-19 pandemic in China, but...
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Maternal distress, parenting stress, maladaptive parenting and children’s problematic media use in China: evidence from 2022 spring in Shanghai
The COVID-19 lockdown has forced young children to spend more time on media and significantly impacted their mothers’ mental health. This study...
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Sedentary behavior is associated with the mental health of university students during the Covid-19 pandemic, and not practicing physical activity accentuates its adverse effects: cross-sectional study
BackgroundMovement behaviours, such as sedentary behavior (SB) and physical inactivity, have become a public health issue due to their implications...
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The association between air pollution and obesity: an umbrella review of meta-analyses and systematic reviews
The objective of this umbrella review was to investigate comprehensive and synthesized evidence of the association between ambient air pollution and...
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Transplant of fecal microbiota from healthy young mice relieves cognitive defects in late-stage diabetic mice by reducing metabolic disorders and neuroinflammation
Fecal microbiota transplant (FMT) is becoming as a promising area of interest for treating refractory diseases. In this study, we investigated the...
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A Persian validation of the burnout assessment tool
BackgroundBurnout is an increasing public health concern. Its prevalence has extended across diverse professions globally, posing significant...
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Associations between 25 hydroxyvitamin D concentration and spontaneous abortion
BackgroundSpontaneous abortion is a common complication of pregnancy that can lead to adverse physical and psychological outcomes for women. Vitamin...
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FXR activation remodels hepatic and intestinal transcriptional landscapes in metabolic dysfunction-associated steatohepatitis
The escalating obesity epidemic and aging population have propelled metabolic dysfunction-associated steatohepatitis (MASH) to the forefront of...
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Estimating vaccine effectiveness against COVID-19 using cause-specific sick leave as an indicator: a nationwide population-based cohort study, Norway, July 2021 – December 2022
BackgroundDue to changes in testing policy and increased use of rapid tests, other indicators for SARS-CoV-2 infections are needed to monitor vaccine...
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Spatial and trend analysis of gestational syphilis cases in Brazil from 2011 to 2020: an ecological study
ObjectivesTo analyze the rate of gestational syphilis (GS) based on temporal trends over 11 years, as well as the spatial distribution of GS in...
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Uncovering the role of ferroptosis in Bietti crystalline dystrophy and potential therapeutic strategies
PurposeBietti crystalline dystrophy (BCD) is an inherited retinal degeneration disease caused by mutations in the CYP4V2 gene. Currently, there is...
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The impact of sleep quality on emotion regulation difficulties in adolescents: a chained mediation model involving daytime dysfunction, social exclusion, and self-control
ObjectivePrevious studies have revealed associations between sleep quality and mental health, yet the comprehensive role of sleep quality, daytime...
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Health and wellbeing of staff working at higher education institutions globally during the post-COVID-19 pandemic period: evidence from a cross-sectional study
BackgroundThe ongoing global crisis of Higher Education (HE) institutions during the post-COVID-19 pandemic period has increased the likelihood of...
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The burden of non-alcoholic fatty liver disease among working-age people in the Western Pacific Region, 1990–2019: an age–period–cohort analysis of the Global Burden of Disease study
BackgroundThe growing prevalence of non-alcoholic fatty liver disease (NAFLD) in younger populations, particularly those of working age...
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Carotid artery transplantation of brain endothelial cells enhances neuroprotection and neurorepair in ischaemic stroke rats
Brain microvascular endothelial cells (BMECs), an important component of the neurovascular unit, can promote angiogenesis and synaptic formation in...
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Prevalence of thyroid nodule and relationship with physiological and psychosocial factors among adults in Zhejiang Province, China: a baseline survey of a cohort study
BackgroundThyroid nodules have attracted much attention due to their high incidence and potential for malignant transformation. Compared with the...