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N6-methyladenosine modification of circMARK2 enhances cytoplasmic export and stabilizes LIN28B, contributing to the progression of Wilms tumor
BackgroundThe potential involvement of circular RNAs (circRNAs) and N 6 -methyladenosine (m 6 A) modification in the progression of Wilms tumor (WT) has...
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From bench to bedside: the application of cannabidiol in glioma
Glioma is the most common malignant tumor in central nervous system, with significant health burdens to patients. Due to the intrinsic...
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Living-donor lobar lung transplantation for pulmonary Langerhans cell histiocytosis complicated by extensive thrombi in central pulmonary arteries
BackgroundPulmonary Langerhans cell histiocytosis (PLCH) is a rare disorder characterized by the proliferation of Langerhans cells along the small...
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Selective iliofemoral stent placement for complex pediatric cases: a decade of institutional experience
BackgroundPediatric iliofemoral venous thromboembolism that is resistant to conventional treatments poses significant management challenges. Stent...
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89Zr-immunoPET-guided selection of a CD33xIL15 fusion protein optimized for antitumor immune cell activation and in vivo tumour retention in acute myeloid leukaemia
PurposeImmune cells are capable of eliminating leukemic cells, as evidenced by outcomes in hematopoietic cell transplantation (HCT). However,...
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The RNA helicases DDX19A/B modulate selinexor sensitivity by regulating MCL1 mRNA nuclear export in leukemia cells
Selinexor, a first-in-class exportin1 (XPO1) inhibitor, is an attractive anti-tumor agent because of its unique mechanisms of action; however, its...
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The SHOW RESPECT adaptable framework of considerations for planning how to share trial results with participants, based on qualitative findings from trial participants and site staff
BackgroundSharing trial results with participants is a moral imperative, but too often does not happen in appropriate ways.
MethodsWe carried out...
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Effect of modified Baduan** exercise on nutritional status in patients with nasopharyngeal carcinoma: a randomized controlled trial
BackgroundAs a traditional Chinese fitness technique, Baduan** is a low- to medium-intensity aerobic exercise that has a common regulatory effect on...
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Assessment of the American College of Radiology Thyroid Imaging Reporting and Data System (ACR TI-RADS™) with modification of the management recommendations for pediatric thyroid nodules
BackgroundThyroid nodules are unusual in children, but when present, they carry a higher risk for malignancy, as compared to adults. Several...
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“Not me!” a qualitative, vignette-based study of nurses’ and physicians’ reactions to spiritual distress on neuro-oncological units
PurposePeople with primary malignant brain tumors experience serious health-related suffering caused by limited prognosis and high symptom burden....
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Minimally invasive approach in a rare emergency surgery, gallbladder perforation
BackgroundGallbladder perforations are challenging to manage for surgeons due to their high morbidity and mortality, rarity, and surgical approach....
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Transperineal laser ablation (TPLA) of the prostate for benign prostatic obstruction: the first 100 patients cohort of a prospective, single-center study
PurposeTransperineal laser ablation (TPLA) is a new minimally-invasive surgical treatment for patients with benign prostatic obstruction (BPO). We...
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Bone Turnover Markers Levels in a Cohort of Egyptian Children with Sickle Cell Disease
Bony complications are variable and common in sickle cell disease. Bone turnover markers are a reflection of bone new bone formation or degradation....