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Plac8-ERK pathway modulation of monocyte function in sepsis
Sepsis, a life-threatening condition caused by infection, is characterized by the dysregulation of immune responses and activation of monocytes....
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Schlafen 11 further sensitizes BRCA-deficient cells to PARP inhibitors through single-strand DNA gap accumulation behind replication forks
The preferential response to PARP inhibitors (PARPis) in BRCA-deficient and Schlafen 11 (SLFN11)-expressing ovarian cancers has been documented, yet...
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The emerging role of nuclear receptor coactivator 4 in health and disease: a novel bridge between iron metabolism and immunity
Nuclear receptor coactivator 4 (NCOA4) has recently been recognized as a selective cargo receptor of ferritinophagy participating in ferroptosis....
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Anti-CCL2 therapy reduces oxygen toxicity to the immature lung
Oxygen toxicity constitutes a key contributor to bronchopulmonary dysplasia (BPD). Critical step in the pathogenesis of BPD is the inflammatory...
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Hodgkin lymphoma and liquid biopsy: a story to be told
Hodgkin lymphoma (HL) represents a neoplasm primarily affecting adolescents and young adults, necessitating the development of precise diagnostic and...
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The anti-tumor effect of trifluridine via induction of aberrant mitosis is unaffected by mutations modulating p53 activity
The fluorinated thymidine analog trifluridine (FTD) is a chemotherapeutic drug commonly used to treat cancer; however, the mechanism by which FTD...
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LILRB4 on multiple myeloma cells promotes bone lesion by p-SHP2/NF-κB/RELT signal pathway
BackgroundLeukocyte Ig-like receptor B family 4 (LILRB4) as an immune checkpoint on myeloid cells is a potential target for tumor therapy. Extensive...
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Monitoring changing patterns in HER2 addiction by liquid biopsy in advanced breast cancer patients
BackgroundDuring targeted treatment, HER2-positive breast cancers invariably lose HER2 DNA amplification. In contrast, and interestingly, HER2...
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TRIM65 deficiency alleviates renal fibrosis through NUDT21-mediated alternative polyadenylation
Chronic kidney disease (CKD) is a major global health concern and the third leading cause of premature death. Renal fibrosis is the primary process...
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Determinants of p53 DNA binding, gene regulation, and cell fate decisions
The extent to which transcription factors read and respond to specific information content within short DNA sequences remains an important question...
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Differential transcriptional invasion signatures from patient derived organoid models define a functional prognostic tool for head and neck cancer
Clinical outcome for patients suffering from HPV-negative head and neck squamous cell carcinoma (HNSCC) remains poor. This is mostly due to highly...
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Mechanisms contributing to inhibition of retinal ganglion cell death by cell permeable peptain-1 under glaucomatous stress
This study assesses the neuroprotective potential of CPP-P1, a conjugate of an anti-apoptotic peptain-1 (P1) and a cell-penetrating peptide (CPP) in...
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Oligomerization regulates the interaction of Gemin5 with members of the SMN complex and the translation machinery
RNA-binding proteins are multifunctional molecules impacting on multiple steps of gene regulation. Gemin5 was initially identified as a member of the...
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Transcriptomics-based liquid biopsy panel for early non-invasive identification of peritoneal recurrence and micrometastasis in locally advanced gastric cancer
BackgroundThis study aimed to develop a novel six-gene expression biomarker panel to enhance the early detection and risk stratification of...
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Estrogen-related receptor alpha promotes thyroid tumor cell survival via a tumor subtype-specific regulation of target gene networks
Mortalin (encoded by HSPA9 ) is a mitochondrial chaperone often overexpressed in cancer through as-yet-unknown mechanisms. By searching different...
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Shikonin blocks CAF-induced TNBC metastasis by suppressing mitochondrial biogenesis through GSK-3β/NEDD4-1 mediated phosphorylation-dependent degradation of PGC-1α
BackgroundTriple-negative breast cancer (TNBC) is characterized by its high metastatic potential, which results in poor patient survival....
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Enhancer engagement sustains oncogenic transformation and progression of B-cell precursor acute lymphoblastic leukemia
BackgroundEnhancer reprogramming plays a significant role in the heterogeneity of cancer. However, we have limited knowledge about the impact of...
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Evaluation of the gene fusion landscape in early onset sporadic rectal cancer reveals association with chromatin architecture and genome stability
Gene fusions represent a distinct class of structural variants identified frequently in cancer genomes across cancer types. Several gene fusions...
