111 Result(s)
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Open AccessContinuous preparation and reaction of nonaflyl azide (NfN3) for the synthesis of organic azides and 1,2,3-triazoles
Organic azides are widely used in organic synthesis. Continuous flow processing can be used to bypass their isolation, and can therefore be useful in mitigating the hazards associated with these potentially to...
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Open AccessPerformance of different microfluidic devices in continuous liquid-liquid separation
Droplet-based microfluidics exhibit numerous benefits leading to relevant innovations and many applications in various fields. The precise handling of droplets in capillaries, including droplet formation, mani...
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Open AccessFlow chemical laboratory practice for undergraduate students: synthesis of paracetamol
Generally, chemical engineering students get well acquainted with the batch synthesis of various active pharmaceutical ingredients, however, only tiny focus is provided to undergraduates on the topic of flow c...
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Open Access3D-printed open-source sensor flow cells for microfluidic temperature, electrical conductivity, and pH value determination
Due to the miniaturization of equipment for flow chemistry and microprocess engineering, low-cost sensors and analytical devices are becoming increasingly important for automated inline process control and mon...
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Open AccessThe continuous flow synthesis of azos
Azo compounds find use in many areas of science, displaying crucial properties for important applications as photoconductive organic pigments, fluorescent quenchers, paints, cosmetics, inks, and in the large a...
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Open AccessRapid prototy** of a modular optical flow cell for image-based droplet size measurements in emulsification processes
Emulsification processes are often found in the process industry and their evaluation is crucial for product quality and safety. Numerous methods exist to analyze critical quality attributes (CQA) such as the ...
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Open AccessPerspectives on flow biocatalysis: the engine propelling enzymatic reactions
Flow biocatalysis has emerged as an empowering tool to boost the potential of enzymatic reactions towards more automatized, sustainable, and generally efficient synthetic processes. In the last fifteen years, ...
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Open AccessAsymmetric electrochemical synthesis in flow
We are currently experiencing a resurgence in the realm of electrochemical organic synthesis, driven by the transformative potential of conducting redox chemistry under mild conditions through the simple use o...
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Open AccessContinuous flow synthesis of meso-substituted porphyrins with inline UV–Vis analysis
Porphyrin derivatives have found diverse applications due to their attractive photophysical and catalytic properties, but remain challenging to synthesize, particularly at scale. Porphyrin synthesis thus stand...
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Open AccessAn affordable, programmable and interactive continuous flow Photoreactor setup for undergraduate organic synthetic teaching labs
Photochemistry and continuous flow chemistry are synthetic technology platforms that have witnessed an increasing uptake by chemical industries interested in complex organic molecule synthesis. Simultaneously,...
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Open AccessTwo photons are better than one: continuous flow synthesis of ꞵ-lactones through a doubly photochemically-activated Paternò-Büchi reaction
In this paper we report a [2 + 2] cycloaddition reaction between ketenes and benzils, characterized by an unusual double photochemical activation triggered by visible light. Employment of a flow system and opt...
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Open AccessThe joint effort of enzyme technology and flow chemistry to bring biocatalytic processes to the next level of sustainability, efficiency and productivity
The number of biocatalyzed reactions at industrial level is growing rapidly together with our understanding on how we can maximize the enzyme efficiency, stability and productivity. While biocatalysis is nowad...
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Open AccessEnantioselective catalytic Strecker reaction on cyclic (Z)-aldimines in flow: reaction optimization and sustainability aspects
Catalytic enantioselective Strecker reactions on an achiral substrate using sub-stoichiometric amounts of a chiral catalyst represent an evolving key strategy for the effective synthesis of α-amino nitriles. W...
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Open AccessAdvances in cofactor immobilization for enhanced continuous-flow biocatalysis
The merging of biocatalysis with continuous-flow chemistry opens up new opportunities for sustainable and efficient chemical synthesis. Cofactor-dependent enzymes are essential for various industrially attract...
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Open AccessLeveraging flow chemistry for the synthesis of trisubstituted isoxazoles
The synthesis of trisubstituted isoxazoles generally requires multiple individual chemical steps, making them amenable to improvements in efficiency by telesco** as a multistep flow process. Three steps (oxi...
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Open AccessInvestigations on the continuous flow generation of 2,6-dichloro-N-fluoropyridinium tetrafluoroborate using F2 gas
An explorative study on the continuous flow generation of the N-F reagent 2,6-dichloro-1-fluoro-pyridinium tetrafluoroborate from 2-6-dichloropyridine and 10% F2/N2 and its telescoped downstream electrophilic flu...
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Open AccessContinuous flow process development for the synthesis of an industrial raw material via solvent-free aromatic Claisen rearrangement
A high-temperature continuous flow protocol is reported for the intensified synthesis of an important industrial raw material via aromatic Claisen rearrangement of the corresponding diallyl ether precursor. Th...
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Open Access3D printed reactors and Kessil lamp holders for flow photochemistry: design and system standardization
A low-cost 3D printed standardized flow-photochemistry setup has been designed and developed for use with a pressure-driven flow system using photochemistry lamps available in most laboratories. In this resear...
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Open AccessDevelopment of an automated flow chemistry affinity-based purification process for DNA-encoded chemistry
An automated flow chemistry platform for DNA-encoded library (DEL) technologies requires the integration of a purification process for DNA-tagged substrates. It facilitates the development of further DEL react...
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Open AccessCorrection to: FOMSy: 3D-printed flexible open-source microfluidic system and flow synthesis of PET-tracer
