491 Result(s)
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Article
Open AccessThe economic burden of pediatric growth hormone deficiency in Italy: a cost of illness study
Growth hormone deficiency (GHD) is a rare condition with a worldwide prevalence of 1 patient in 4000 to 10,000 live births, placing a significant economic burden on healthcare systems. The aim of this study is...
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Article
Open AccessReal-life data of Pasireotide LAR in acromegaly: a long-term follow-up
Pasireotide LAR (PAS-LAR) was released in Italy in 2017 to treat acromegaly patients resistant to SRLs (Somatostatin Receptors Ligands). The long-term follow-up data of PAS-LAR therapy in Italy are limited. Th...
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Article
Open AccessA novel likely pathogenetic variant p.(Cys235Arg) of the MEN1 gene in multiple endocrine neoplasia type 1 with multifocal glucagonomas
Multiple endocrine neoplasia type 1 (MEN1) is a hereditary endocrine syndrome caused by pathogenic variants in MEN1 tumor suppressor gene. Diagnosis is commonly based on clinical criteria and confirmed by genetic...
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Open AccessDifferential effects of teriparatide, denosumab and zoledronate on hip structural and mechanical parameters in osteoporosis; a real-life study
The aim of this study was to evaluate changes in hip geometry parameters following treatment with teriparatide (TPD), denosumab (Dmab) and zoledronate (ZOL) in real-life setting.
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Open AccessSemen quality and metabolic profile in people with type 1 diabetes with and without erectile dysfunction: a cross-sectional study
The aim of the present study is to evaluate the association of metabolic and glycemic variables with semen parameters in patients with type 1 diabetes (T1D) with and without erectile dysfunction (ED).
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Article
Open AccessEndocrine manifestations in adults with 22q11.2 deletion syndrome: a retrospective single-center cohort study
Patients with the 22q11.2 deletion syndrome (22q11DS) frequently display cardiological and psychiatric diseases, but are also at increased risk for endocrine manifestations. The aim of this study was to evalua...
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Open AccessPredicting postoperative hypocortisolism in patients with non-aldosterone-producing adrenocortical adenoma: a retrospective single-centre study
Limited information exists on postoperative hypocortisolism and hypothalamus–pituitary–adrenal axis recovery in patients with adrenal incidentaloma following unilateral adrenalectomy. We evaluated frequency of...
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Open AccessSleeve gastrectomy links the attenuation of diabetic kidney disease to the inhibition of renal tubular ferroptosis through down-regulating TGF-β1/Smad3 signaling pathway
To investigate how sleeve gastrectomy (SG), a typical operation of bariatric surgery, attenuated symptom, and progression of diabetic kidney disease (DKD).
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Article
Open AccessPsychological symptoms and brain activity alterations in women with PCOS and their relation to the reduced quality of life: a narrative review
Polycystic ovary syndrome (PCOS) is the most common feminine endocrine disorder, characterized by androgen excess, ovulatory dysfunction, and polycystic ovarian morphology. The negative impact of symptoms on t...
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Open AccessUltrasound-based quantitative tools in predicting renal involvement in asymptomatic primary hyperparathyroidism
Asymptomatic primary hyperparathyroidism (aPHPT) has been recognized as a condition that can lead to renal complications. Timely identification of prognostic indicators for renal impairment holds the potential...
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Article
Open AccessTransition from pediatric to adult care in patients with Turner syndrome in Italy: a consensus statement by the TRAMITI project
Transition from pediatric to adult care is associated with significant challenges in patients with Turner syndrome (TS). The objective of the TRansition Age Management In Turner syndrome in Italy (TRAMITI) pro...
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Open AccessOnce upon a time: the glucagon stimulation test in diagnosing adult GH deficiency
The clinical features of adult GH deficiency (GHD) are nonspecific, and its diagnosis is established through GH stimulation testing, which is often complex, expensive, time-consuming and may be associated with...
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Open AccessImproved overall survival in patients develo** endocrine toxicity during treatment with nivolumab for advanced non-small cell lung cancer in a prospective study
Immune checkpoint inhibitors (ICPIs) disrupting PD-1/PD-L1 axis have revolutionized the management of advanced non-small cell lung cancer (NSCLC). Some studies identified the development of endocrine toxicity ...
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Open AccessGlycemic control and cancer outcomes in oncologic patients with diabetes: an Italian Association of Medical Oncology (AIOM), Italian Association of Medical Diabetologists (AMD), Italian Society of Diabetology (SID), Italian Society of Endocrinology (SIE), Italian Society of Pharmacology (SIF) multidisciplinary critical view
Background: Increasing evidence suggests that diabetes increases the risk of develo** different types of cancer. Hyperinsulinemia, hyperglycemia and chronic inflammation, characteristic of diabetes, could re...
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Article
Open AccessScreening of hypercortisolism among patients with hypertension: an Italian nationwide survey
Screening of Cushing Syndrome (CS) and Mild Autonomous Cortisol Secretion (MACS) in hypertensive patients is crucial for proper treatment. The aim of the study was to investigate screening and management of hy...
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Open AccessInfluence of state-of-the-art laboratory techniques on the phenoty** of women with polycystic ovary syndrome in the clinical setting
Evidence-based guidelines for the management of polycystic ovary syndrome (PCOS) recommend clinical laboratories use liquid chromatography-tandem mass spectrometry (LC–MS/MS) for diagnosing biochemical hyperan...
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Article
Open AccessBiochemical liver damage during gender affirming therapy in trans adults assigned female at birth: a meta-analysis
To assess the effects of testosterone (T)-based gender affirming hormone therapy (GAHT) on liver blood tests (LBTs) in assigned female at birth adults, using a meta-analytic approach.
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Open AccessGetting old in the desired gender: a systematic review on aging diseases in transgender people
The growing demographic presence of the transgender (TGD) population has sparked an increase in clinical investigations focusing on the impacts of gender-affirming hormone therapy (GAHT) in adults with gender ...
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Open AccessGut microbiota and fecal volatilome profile inspection in metabolically healthy and unhealthy obesity phenotypes
People with metabolically healthy (MHO) and metabolically unhealthy obesity (MUO) differ for the presence or absence of cardio-metabolic complications, respectively.
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Open AccessSelective anti-CXCR2 receptor blockade by AZD5069 inhibits CXCL8-mediated pro-tumorigenic activity in human thyroid cancer cells in vitro
Thyroid cancer is the most common endocrine malignancy. Current therapies are successful, however some patients progress to therapeutically refractive disease. The immunotherapeutic potential of the CXCL8-chem...
