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Influence of periodic pulse intake on the ventilation efficiency of positive pressure explosion-proof robot
The ventilation work is an important step to be completed before the start of the positive pressure explosion-proof robot. The existing...
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Proof of biased behavior of Normalized Mutual Information
The Normalized Mutual Information (NMI) metric is widely utilized in the evaluation of clustering and community detection algorithms. This study...
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Health effects associated with chewing tobacco: a Burden of Proof study
Chewing tobacco use poses serious health risks; yet it has not received as much attention as other tobacco-related products. This study synthesizes...
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A burden of proof study on alcohol consumption and ischemic heart disease
Cohort and case-control data have suggested an association between low to moderate alcohol consumption and decreased risk of ischemic heart disease...
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Adapting blockchain’s proof-of-work mechanism for multiple traveling salesmen problem optimization
The blockchain network uses a Proof-of-Work (PoW) mechanism to validate transactions and keep the blockchain growth safe against tampering, but it is...
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Proof of concept for quantitative adverse outcome pathway modeling of chronic toxicity in repeated exposure
Adverse Outcome Pathway (AOP) is a useful tool to glean mode of action (MOE) of a chemical. However, in order to use it for the purpose of risk...
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Statistical detection of selfish mining in proof-of-work blockchain systems
The core of many cryptocurrencies is the decentralised validation network operating on proof-of-work technology. In these systems, validation is done...
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Automatic GAN-based MRI volume synthesis from US volumes: a proof of concept investigation
Usually, a baseline image, either through magnetic resonance imaging (MRI) or computed tomography (CT), is captured as a reference before medical...
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Proof-of-concept study evaluating humoral primary immunodeficiencies via CJ:KREC ratio and serum BAFF level
Humoral primary immunodeficiencies are the most prevalent form of primary immunodeficiency (PID). Currently, there is no convenient method to...
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Cylindrical TGR as early radiological predictor of RLT progression in GEPNETs: a proof of concept
This study aims to assess the predictive capability of cylindrical Tumor Growth Rate (cTGR) in the prediction of early progression of...
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Proof–of–concept evidence for high–density EEG investigation of sleep slow wave traveling in First-Episode Psychosis
Schizophrenia is thought to reflect aberrant connectivity within cortico-cortical and reentrant thalamo-cortical loops, which physiologically...
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Chemogenetic inhibition of the lateral hypothalamus effectively reduces food intake in rats in a translational proof-of-concept study
Despite the therapeutic potential of chemogenetics, the method lacks comprehensive preclinical validation, hindering its progression to human...
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Non-invasive screening of breast cancer from fingertip smears—a proof of concept study
Breast cancer is a global health issue affecting 2.3 million women per year, causing death in over 600,000. Mammography (and biopsy) is the gold...
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Functionalized magnetic nanoparticles remove donor-specific antibodies (DSA) from patient blood in a first ex vivo proof of principle study
The presence of donor-specific antibodies (DSA) such as antibodies directed against donor class I human leucocyte antigen (e.g., HLA-A) is a major...
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Proof of concept for a new sensor to monitor marine litter from space
Worldwide, governments are implementing strategies to combat marine litter. However, their effectiveness is largely unknown because we lack tools to...
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A proof-of-concept study of vicarious extinction learning and autonomic synchrony in parent–child dyads and posttraumatic stress disorder
Though threat-extinction models continue to inform scientific study of traumatic stress, knowledge of learning and extinction as mechanisms linking...
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11β-HSD1 inhibition in men mitigates prednisolone-induced adverse effects in a proof-of-concept randomised double-blind placebo-controlled trial
Glucocorticoids prescribed to limit inflammation, have significant adverse effects. As 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) regenerates...
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Modifying Pavlovian-to-instrumental transfer by approach avoidance training in healthy subjects: a proof of concept study
The modulation of instrumental action by conditioned Pavlovian cues is hypothesized to play a role in the emergence and maintenance of maladaptive...
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Proof of principle study: synchrotron X-ray fluorescence microscopy for identification of previously radioactive microparticles and elemental map** of FFPE tissues
Biobanks containing formalin-fixed, paraffin-embedded (FFPE) tissues from animals and human atomic-bomb survivors exposed to radioactive particulates...
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A proof of concept for a deep learning system that can aid embryologists in predicting blastocyst survival after thaw
The ability to understand whether embryos survive the thaw process is crucial to transferring competent embryos that can lead to pregnancy. The...
