Search
Search Results
-
Single-cell analysis reveals ADGRL4+ renal tubule cells as a highly aggressive cell type in clear cell renal cell carcinoma
Clear cell renal cell carcinoma (ccRCC) is a highly heterogeneous cancer that poses great challenge to clinical treatment and prognostic prediction....
-
Single cell multi-omics reveal intra-cell-line heterogeneity across human cancer cell lines
Human cancer cell lines have long served as tools for cancer research and drug discovery, but the presence and the source of intra-cell-line...
-
Defining and identifying cell sub-crosstalk pairs for characterizing cell–cell communication patterns
Current cell–cell communication analysis focuses on quantifying intercellular interactions at cell type level. In the tissue microenvironment, one...
-
Subty** of COVID-19 samples based on cell-cell interaction in single cell transcriptomes
In single-cell transcriptome analysis, numerous biomarkers related to COVID-19 severity, including cell subtypes, genes, and pathways, have been...
-
An alternative cell cycle coordinates multiciliated cell differentiation
The canonical mitotic cell cycle coordinates DNA replication, centriole duplication and cytokinesis to generate two cells from one
1 . Some cells, such...
-
Cell-in-cell phenomena across the tree of life
Cells in obligately multicellular organisms by definition have aligned fitness interests, minimum conflict, and cannot reproduce independently....
-
Naturally occurring T cell mutations enhance engineered T cell therapies
Adoptive T cell therapies have produced exceptional responses in a subset of patients with cancer. However, therapeutic efficacy can be hindered by...
-
Inference of cell type-specific gene regulatory networks on cell lineages from single cell omic datasets
Cell type-specific gene expression patterns are outputs of transcriptional gene regulatory networks (GRNs) that connect transcription factors and...
-
Single-cell analysis reveals context-dependent, cell-level selection of mtDNA
Heteroplasmy occurs when wild-type and mutant mitochondrial DNA (mtDNA) molecules co-exist in single cells
1 . Heteroplasmy levels change dynamically...
-
Cell type signatures in cell-free DNA fragmentation profiles reveal disease biology
Circulating cell-free DNA (cfDNA) fragments have characteristics that are specific to the cell types that release them. Current methods for cfDNA...
-
Reversible photoregulation of cell-cell adhesions with opto-E-cadherin
E-cadherin-based cell-cell adhesions are dynamically and locally regulated in many essential processes, including embryogenesis, wound healing and...
-
Single-cell and spatial transcriptomics analysis of non-small cell lung cancer
Lung cancer is the second most frequently diagnosed cancer and the leading cause of cancer-related mortality worldwide. Tumour ecosystems feature...
-
Domain generalization enables general cancer cell annotation in single-cell and spatial transcriptomics
Single-cell and spatial transcriptome sequencing, two recently optimized transcriptome sequencing methods, are increasingly used to study cancer and...
-
Leveraging diverse cell-death patterns to predict the prognosis, immunotherapy and drug sensitivity of clear cell renal cell carcinoma
Clear cell renal cell carcinoma (ccRCC) poses clinical challenges due to its varied prognosis, tumor microenvironment attributes, and responses to...
-
Annotated Pap cell images and smear slices for cell classification
Machine learning-based systems have become instrumental in augmenting global efforts to combat cervical cancer. A burgeoning area of research focuses...
-
Deciphering driver regulators of cell fate decisions from single-cell transcriptomics data with CEFCON
Single-cell technologies enable the dynamic analyses of cell fate map**. However, capturing the gene regulatory relationships and identifying the...
-
A robust model for cell type-specific interindividual variation in single-cell RNA sequencing data
Single-cell RNA sequencing (scRNA-seq) has been widely used to characterize cell types based on their average gene expression profiles. However, most...
-
Single-cell integrative analysis reveals consensus cancer cell states and clinical relevance in breast cancer
High heterogeneity and complex interactions of malignant cells in breast cancer has been recognized as a driver of cancer progression and therapeutic...
-
Immune cell identifier and classifier (ImmunIC) for single cell transcriptomic readouts
Single cell RNA sequencing has a central role in immune profiling, identifying specific immune cells as disease markers and suggesting therapeutic...
-
Interrogations of single-cell RNA splicing landscapes with SCASL define new cell identities with physiological relevance
RNA splicing shapes the gene regulatory programs that underlie various physiological and disease processes. Here, we present the SCASL (single-cell...
