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Collective total synthesis of stereoisomeric yohimbine alkaloids
Stereoisomeric polycyclic natural products are important for drug discovery-based screening campaigns, due to the close correlation of...
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Modular assembly of indole alkaloids enabled by multicomponent reaction
Indole alkaloids are one of the largest alkaloid classes, proving valuable structural moiety in pharmaceuticals. Although methods for the synthesis...
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Modular assembly of an artificially concise biocatalytic cascade for the manufacture of phenethylisoquinoline alkaloids
Plant-derived alkaloids are an important class of pharmaceuticals. However, they still rely on phytoextraction to meet their diverse market demands....
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Catalytic enantioselective reductive alkynylation of amides enables one-pot syntheses of pyrrolidine, piperidine and indolizidine alkaloids
The primary objective in synthetic organic chemistry is to develop highly efficient, selective, and versatile synthetic methodologies, which are...
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Synthetic aporphine alkaloids are potential therapeutics for Leigh syndrome
Mitochondrial diseases are mainly caused by dysfunction of mitochondrial respiratory chain complexes and have a variety of genetic variants or...
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A Bischler-Napieralski and homo-Mannich sequence enables diversified syntheses of sarpagine alkaloids and analogues
Sarpagine alkaloids offer signicant opportunities in drug discovery, yet the efficient total syntheses and diverse structural modifications of these...
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Multiple independent losses of the biosynthetic pathway for two tropane alkaloids in the Solanaceae family
Hyoscyamine and scopolamine (HS), two valuable tropane alkaloids of significant medicinal importance, are found in multiple distantly related...
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Collective total synthesis of C4-oxygenated securinine-type alkaloids via stereocontrolled diversifications on the piperidine core
Securinega alkaloids have fascinated the synthetic chemical community for over six decades. Historically, major research foci in securinega alkaloid...
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The effects of green and chemically-synthesized copper oxide nanoparticles on the production and gene expression of morphinan alkaloids in Oriental poppy
Oriental poppy ( Papaver orientale L.) belonging to the Papaveraceae family, has the capacity to synthesize a wide range of benzylisoquinoline...
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Structure units oriented approach towards collective synthesis of sarpagine-ajmaline-koumine type alkaloids
Sarpagine-Ajmaline-Koumine type monoterpenoid indole alkaloids represent a fascinating class of natural products with polycyclic and cage-like...
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Antiviral activities of plant-derived indole and β-carboline alkaloids against human and avian influenza viruses
The persistent evolution of drug-resistant influenza strains represents a global concern. The innovation of new treatment approaches through drug...
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Implementation of a MS/MS database for isoquinoline alkaloids and other annonaceous metabolites
This data descriptor reports on the upload to a public repository (GNPS) of the IQAMDB, IsoQuinoline and Annonaceous Metabolites Data Base,...
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Metabolomics-guided discovery of cytochrome P450s involved in pseudotropine-dependent biosynthesis of modified tropane alkaloids
Plant alkaloids constitute an important class of bioactive chemicals with applications in medicine and agriculture. However, the knowledge gap of the...
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Enzymatic synthesis of benzylisoquinoline alkaloids using a parallel cascade strategy and tyrosinase variants
Benzylisoquinoline alkaloid derived pharmaceuticals are widely applied in modern medicines. Recent studies on the microbial production of...
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Activity of alkaloids from Aspidosperma nitidum against Leishmania (Leishmania) amazonensis
This study evaluated the morphological changes caused by fractions and subfractions, obtained from barks of Aspidosperna nitidum , against L . ( L .) amazonensis...
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Differential effects of alkaloids on memory in rodents
Nicotinic acetylcholine receptors (nAChRs) play a critical role in the neuropharmacology of learning and memory. As such, naturally occurring...
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Optimization of supercritical-CO2 extraction and pharmacokinetics in SD rats of alkaloids form Sophora moorcroftiana seed
The total alkaloids extracted from the seeds of Sophora moorcroftiana (TAs-SM) have the potential to treat alveolar echinococcosis, a disease...
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Changes in amino acids, catechins and alkaloids during the storage of oolong tea and their relationship with antibacterial effect
The storage process has a significant impact on tea quality. Few is known about effect of storage on quality of oolong tea. This study aimed to...
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Analysis of the Coptis chinensis genome reveals the diversification of protoberberine-type alkaloids
Chinese goldthread ( Coptis chinensis Franch.), a member of the Ranunculales, represents an important early-diverging eudicot lineage with diverse...
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Biosyntheses characterization of alkaloids and flavonoids in Sophora flavescens by combining metabolome and transcriptome
Sophora flavescens are widely used for their pharmacological effects. As its main pharmacological components, alkaloids and flavonoids are...
