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Trimethylamine N-oxide impairs β-cell function and glucose tolerance
β-Cell dysfunction and β-cell loss are hallmarks of type 2 diabetes (T2D). Here, we found that trimethylamine N-oxide (TMAO) at a similar...
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Evidence of a causal and modifiable relationship between kidney function and circulating trimethylamine N-oxide
The host-microbiota co-metabolite trimethylamine N -oxide (TMAO) is linked to increased cardiovascular risk but how its circulating levels are...
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Brown adipose tissue dysfunction promotes heart failure via a trimethylamine N-oxide-dependent mechanism
Low body temperature predicts a poor outcome in patients with heart failure, but the underlying pathological mechanisms and implications are largely...
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Time-dependent specific molecular signatures of inflammation and remodelling are associated with trimethylamine-N-oxide (TMAO)-induced endothelial cell dysfunction
Endothelial dysfunction is a critical initiating factor contributing to cardiovascular diseases, involving the gut microbiome-derived metabolite...
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Effects of acute administration of trimethylamine N-oxide on endothelial function: a translational study
Elevated circulating levels of nutrient-derived trimethylamine N-oxide (TMAO) have been associated with the onset and progression of cardiovascular...
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Electronic fluctuation difference between trimethylamine N-oxide and tert-butyl alcohol in water
Although small organic molecules in cells have been considered important to control the functions of proteins, their electronic fluctuation and the...
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Gut microbiota-generated metabolite, trimethylamine-N-oxide, and subclinical myocardial damage: a multicenter study from Thailand
Plasma Trimethylamine- N -oxide (TMAO), a gut microbiota metabolite from dietary phosphatidylcholine, is mechanistically linked to cardiovascular...
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Metformin decreases bacterial trimethylamine production and trimethylamine N-oxide levels in db/db mice
The current study aimed to explore whether metformin, the most widely prescribed oral medication for the treatment of type 2 diabetes, alters plasma...
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Gut microbiota derived trimethylamine N-oxide (TMAO) detection through molecularly imprinted polymer based sensor
Trimethylamine N-oxide (TMAO), a microbiota-derived metabolite has been implicated in human health and disease. Its early detection in body fluids...
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Trimethylamine N-oxide and the reverse cholesterol transport in cardiovascular disease: a cross-sectional study
The early atherosclerotic lesions develop by the accumulation of arterial foam cells derived mainly from cholesterol-loaded macrophages. Therefore,...
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Bacterial metabolites trimethylamine N-oxide and butyrate as surrogates of small intestinal bacterial overgrowth in patients with a recent decompensated heart failure
In patients with heart failure (HF), the exhaled concentrations of hydrogen after a breath test—a non-invasive assessment of small intestinal...
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Changes in the concentrations of trimethylamine N-oxide (TMAO) and its precursors in patients with amyotrophic lateral sclerosis
To compare the plasma concentrations of trimethylamine N-oxide (TMAO) and its precursors in amyotrophic lateral sclerosis (ALS) patients, their...
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Trimethylamine-N-Oxide (TMAO) Predicts Cardiovascular Mortality in Peripheral Artery Disease
Peripheral artery disease (PAD) is a major cause of acute and chronic illness, with extremely poor prognosis that remains underdiagnosed and...
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Metabolic Activation of Flavin Monooxygenase-mediated Trimethylamine-N-Oxide Formation in Experimental Kidney Disease
Cardiovascular disease (CVD) remains the leading cause of death in chronic kidney disease (CKD) patients despite treatment of traditional risk...
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Microbiota-derived Trimethylamine N-oxide Predicts Cardiovascular Risk After STEMI
Trimethylamine N-oxide (TMAO), a metabolite derived from the gut microbiota, is proatherogenic and associated with cardiovascular events. However,...
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Retinal artery occlusion is associated with compositional and functional shifts in the gut microbiome and altered trimethylamine-N-oxide levels
Retinal artery occlusion (RAO) is a sight threatening complication of cardiovascular disease and commonly occurs due to underlying atherosclerosis....
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Trimethylamine functionalized radiation-induced grafted polyamide 6 fibers for p-nitrophenol adsorption
The method of pre-irradiation grafting was used with the aid of electron beam (EB) accelerator to accomplish the grafting of polyamide 6 fibers (PA6)...
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Insights in the regulation of trimetylamine N-oxide production using a comparative biomimetic approach suggest a metabolic switch in hibernating bears
Experimental studies suggest involvement of trimethylamine N-oxide (TMAO) in the aetiology of cardiometabolic diseases and chronic kidney disease...
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Evaluating changes in firefighter urinary metabolomes after structural fires: an untargeted, high resolution approach
Firefighters have elevated rates of urinary tract cancers and other adverse health outcomes, which may be attributable to environmental occupational...
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Trimethylamine N-Oxide, Circulating Endothelial Progenitor Cells, and Endothelial Function in Patients with Stable Angina
Trimethylamine N-oxide (TMAO) is a metabolite originated from bacterial metabolism of choline-rich foods. Evidence suggests an association between...
