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Benchmarking of methods for DNA methylome deconvolution
Defining the number and abundance of different cell types in tissues is important for understanding disease mechanisms as well as for diagnostic and...
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Single-cell DNA methylome and 3D multi-omic atlas of the adult mouse brain
Cytosine DNA methylation is essential in brain development and is implicated in various neurological disorders. Understanding DNA methylation...
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Integrative analysis in head and neck cancer reveals distinct role of miRNome and methylome as tumour epigenetic drivers
Head and neck cancer is the sixth most common malignancy worldwide, with the relatively low 5-year survival rate, mainly because it is diagnosed at a...
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The cell-free DNA methylome captures distinctions between localized and metastatic prostate tumors
Metastatic prostate cancer remains a major clinical challenge and metastatic lesions are highly heterogeneous and difficult to biopsy. Liquid biopsy...
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Cost-effective methylome sequencing of cell-free DNA for accurately detecting and locating cancer
Early cancer detection by cell-free DNA faces multiple challenges: low fraction of tumor cell-free DNA, molecular heterogeneity of cancer, and sample...
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Global lysine methylome profiling using systematically characterized affinity reagents
Lysine methylation modulates the function of histone and non-histone proteins, and the enzymes that add or remove lysine methylation—lysine...
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Multimodal analysis of cell-free DNA whole-methylome sequencing for cancer detection and localization
Multimodal epigenetic characterization of cell-free DNA (cfDNA) could improve the performance of blood-based early cancer detection. However,...
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Extensive DNA methylome rearrangement during early lamprey embryogenesis
DNA methylation (5mC) is a repressive gene regulatory mark widespread in vertebrate genomes, yet the developmental dynamics in which 5mC patterns are...
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Integrated methylome and phenome study of the circulating proteome reveals markers pertinent to brain health
Characterising associations between the methylome, proteome and phenome may provide insight into biological pathways governing brain health. Here, we...
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Prognostic and therapeutic prediction by screening signature combinations from transcriptome–methylome interactions in oral squamous cell carcinoma
DNA methylation pattern in oral squamous cell carcinoma (OSCC) remains poorly described. This study aimed to perform a genome-wide integrated...
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Brain methylome remodeling selectively regulates neuronal activity genes linking to emotional behaviors in mice exposed to maternal immune activation
How early life experience is translated into storable epigenetic information leading to behavioral changes remains poorly understood. Here we found...
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Local and global crosstalk among heterochromatin marks drives DNA methylome patterning in Arabidopsis
Transposable elements (TEs) are robustly silenced by multiple epigenetic marks, but dynamics of crosstalk among these marks remains enigmatic. In...
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The DNA cytosine methylome revealed two methylation motifs in the upstream regions of genes related to morphological and physiological differentiation in Streptomyces coelicolor A(3)2 M145
DNA methylation is an epigenetic modification detected in both prokaryotic and eukaryotic genomic DNAs. In bacteria, the importance of...
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A differential DNA methylome signature of pulmonary immune cells from individuals converting to latent tuberculosis infection
Tuberculosis (TB), caused by Mycobacterium tuberculosis, spreads via aerosols and the first encounter with the immune system is with the...
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Different DNA methylome, transcriptome and histological features in uterine fibroids with and without MED12 mutations
Somatic mutations in Mediator complex subunit 12 (MED12m) have been reported as a biomarker of uterine fibroids (UFs). However, the role of MED12m is...
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mRNA ageing shapes the Cap2 methylome in mammalian mRNA
The mRNA cap structure is a major site of dynamic mRNA methylation. mRNA caps exist in either the Cap1 or Cap2 form, depending on the presence of 2′- O ...
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Profiling neuronal methylome and hydroxymethylome of opioid use disorder in the human orbitofrontal cortex
Opioid use disorder (OUD) is influenced by genetic and environmental factors. While recent research suggests epigenetic disturbances in OUD, this is...
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Evolution of DNA methylome from precancerous lesions to invasive lung adenocarcinomas
The evolution of DNA methylome and methylation intra-tumor heterogeneity (ITH) during early carcinogenesis of lung adenocarcinoma has not been...
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The ULK3 kinase is a determinant of keratinocyte self-renewal and tumorigenesis targeting the arginine methylome
Epigenetic mechanisms oversee epidermal homeostasis and oncogenesis. The identification of kinases controlling these processes has direct therapeutic...
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Heterogeneous ozone effects on the DNA methylome of bronchial cells observed in a crossover study
We used a randomized crossover experiment to estimate the effects of ozone (vs. clean air) exposure on genome-wide DNA methylation of target...
