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Enhanced CD95 and interleukin 18 signalling accompany T cell receptor Vβ21.3+ activation in multi-inflammatory syndrome in children
Multisystem inflammatory syndrome in children is a post-infectious presentation SARS-CoV-2 associated with expansion of the T cell receptor Vβ21.3+...
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NOD1 mediates interleukin-18 processing in epithelial cells responding to Helicobacter pylori infection in mice
The interleukin-1 family members, IL-1β and IL-18, are processed into their biologically active forms by multi-protein complexes, known as...
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Correlation between circulating interleukin-18 level and systemic lupus erythematosus: a meta-analysis
This study is a meta-analysis aimed at pooling reported data and clarifying the association between circulating level of interleukin-18 and systemic...
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Metabolic changes of Interleukin-12/15/18-stimulated human NK cells
Natural Killer (NK) cells acquire memory-like properties following a brief stimulation with IL-12, IL-15 and IL-18. These IL-12/15/18-preactivated NK...
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Toxoplasma gondii infection associated with inflammasome activation and neuronal injury
Toxoplasma gondii (TOXO) infection typically results in chronic latency due to its ability to form cysts in the brain and other organs. Latent...
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Interleukin-18 as a drug repositioning opportunity for inflammatory bowel disease: A Mendelian randomization study
Support from human genetics increases the probability of success in drug development. However, few examples exist of successful genomically-driven...
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Elevated levels of IL-12/IL-23p40 in Nova Scotia Duck Tolling Retrievers with autoimmune disease and lymphoma
The Nova Scotia Duck Tolling Retriever (NSDTR) is predisposed to immune mediated rheumatic disease (IMRD), steroid-responsive meningitis-arteritis...
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The role of melatonin in amyloid beta-induced inflammation mediated by inflammasome signaling in neuronal cell lines
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder. In addition to amyloid beta (Aβ) and tau, neuroinflammation is a crucial...
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Effects of dexmedetomidine on A549 non-small cell lung cancer growth in a clinically relevant surgical xenograft model
The perioperative milieu following curative lung cancer surgery is accompanied by a stress response. Inflammasomes mediate inflammation resulting in...
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Lutein isolated from Scenedesmus obliquus microalga boosts immunity against cyclophosphamide-induced brain injury in rats
Lutein is a naturally potent antioxidant carotenoid synthesized in green microalgae with a potent ability to prevent different human chronic...
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Circulating miRNA profiles in COVID-19 patients and meta-analysis: implications for disease progression and prognosis
We compared circulating miRNA profiles of hospitalized COVID-positive patients (n = 104), 27 with acute respiratory distress syndrome (ARDS) and age-...
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Epidemiological and clinical features of SARS-CoV-2 Omicron variant infection in Quanzhou, Fujian province: a retrospective study
Epidemiological and clinical data of patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant (BA.2)...
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A cytomegalovirus inflammasome inhibitor reduces proinflammatory cytokine release and pyroptosis
In response to viral infection, cells can initiate programmed cell death (PCD), leading to a reduction in the release of viral progeny. Viruses have...
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Network pharmacology, computational biology integrated surface plasmon resonance technology reveals the mechanism of ellagic acid against rotavirus
The target and mechanism of ellagic acid (EA) against rotavirus (RV) were investigated by network pharmacology, computational biology, and surface...
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Porphyromonas gingivalis-mediated disruption in spiral artery remodeling is associated with altered uterine NK cell populations and dysregulated IL-18 and Htra1
Impaired spiral artery remodeling (IRSA) underpins the great obstetrical syndromes. We previously demonstrated that intrauterine infection with the...
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Elevated serum levels of bone morphogenetic protein-9 are associated with better outcome in AQP4-IgG seropositive NMOSD
Lymphatic drainage in the central nervous system is regulated by meningeal lymphatic vasculature, and recurrent neuroinflammation alters lymphatic...
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Association between CCR2 and CCL2 expression and NET stimulation in adult-onset Still’s disease
Adult-onset Still’s disease (AOSD) is a systemic inflammatory disease characterized by the activation of monocyte-derived cells and the release of...
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Risk factors for hypoactive delirium in patients with nontraumatic ARDS: a prospective observational study
To investigate the incidence, characteristics and risk factors for hypoactive delirium in patients with nontraumatic acute respiratory distress...
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Parasympathetic tonus in type 2 diabetes and pre-diabetes and its clinical implications
Autonomic imbalance reflected by higher resting heart rate and reduced parasympathetic tone may be driven by low-grade inflammation (LGI) and...
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Structural insights into cytokine cleavage by inflammatory caspase-4
Inflammatory caspases are key enzymes in mammalian innate immunity that control the processing and release of interleukin-1 (IL-1)-family cytokines
1 ,2 ...