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Gene regulation for inflammation and inflammation resolution differs between umbilical arterial and venous endothelial cells
Systemic inflammation affects the whole vasculature, yet whether arterial and venous endothelial cells differ in their abilities to mediate...
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IKKε and TBK1 prevent RIPK1 dependent and independent inflammation
TBK1 and IKKε regulate multiple cellular processes including anti-viral type-I interferon responses, metabolism and TNF receptor signaling. However,...
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IL-10 constrains sphingolipid metabolism to limit inflammation
Interleukin-10 (IL-10) is a key anti-inflammatory cytokine that can limit immune cell activation and cytokine production in innate immune cell types
1 ....
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Sensory ASIC3 channel exacerbates psoriatic inflammation via a neurogenic pathway in female mice
Psoriasis is an immune-mediated skin disease associated with neurogenic inflammation, but the underlying molecular mechanism remains unclear. We...
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Statin prevents cancer development in chronic inflammation by blocking interleukin 33 expression
Chronic inflammation is a major cause of cancer worldwide. Interleukin 33 (IL-33) is a critical initiator of cancer-prone chronic inflammation;...
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cGAS–STING drives ageing-related inflammation and neurodegeneration
Low-grade inflammation is a hallmark of old age and a central driver of ageing-associated impairment and disease
1 . Multiple factors can contribute to...
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CTLA-4-expressing ILC3s restrain interleukin-23-mediated inflammation
Interleukin (IL-)23 is a major mediator and therapeutic target in chronic inflammatory diseases that also elicits tissue protection in the intestine...
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SLAM-family receptors promote resolution of ILC2-mediated inflammation
Type 2 innate lymphoid cells (ILC2) initiate early allergic inflammation in the lung, but the factors that promote subsequent resolution of type 2...
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Evaluation of a new point-of-care diagnostic test measuring inflammation in emergency settings
Erythrocyte aggregation kinetics is accelerated in diseases with a strong inflammation component. This study aimed to evaluate whether, in an...
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CD1a promotes systemic manifestations of skin inflammation
Inflammatory skin conditions are increasingly recognised as being associated with systemic inflammation. The mechanisms connecting the cutaneous and...
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IL-9 aggravates SARS-CoV-2 infection and exacerbates associated airway inflammation
SARS-CoV-2 infection is known for causing broncho-alveolar inflammation. Interleukin 9 (IL-9) induces airway inflammation and bronchial hyper...
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Astrocyte reactivity and inflammation-induced depression-like behaviors are regulated by Orai1 calcium channels
Astrocytes contribute to brain inflammation in neurological disorders but the molecular mechanisms controlling astrocyte reactivity and their...
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Gut inflammation associated with age and Alzheimer’s disease pathology: a human cohort study
Age-related disease may be mediated by low levels of chronic inflammation (“inflammaging”). Recent work suggests that gut microbes can contribute to...
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Periportal macrophages protect against commensal-driven liver inflammation
The liver is the main gateway from the gut, and the unidirectional sinusoidal flow from portal to central veins constitutes heterogenous zones,...
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Epithelial SIRT6 governs IL-17A pathogenicity and drives allergic airway inflammation and remodeling
Dysregulation of IL-17A is closely associated with airway inflammation and remodeling in severe asthma. However, the molecular mechanisms by which...
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Myeloid-derived grancalcin instigates obesity-induced insulin resistance and metabolic inflammation in male mice
The crosstalk between the bone and adipose tissue is known to orchestrate metabolic homeostasis, but the underlying mechanisms are largely unknown....
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Molecular imaging of liver inflammation using an anti-VCAM-1 nanobody
To date, a biopsy is mandatory to evaluate parenchymal inflammation in the liver. Here, we evaluated whether molecular imaging of vascular cell...
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EFHD2 suppresses intestinal inflammation by blocking intestinal epithelial cell TNFR1 internalization and cell death
TNF acts as one pathogenic driver for inducing intestinal epithelial cell (IEC) death and substantial intestinal inflammation. How the IEC death is...
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A druggable copper-signalling pathway that drives inflammation
Inflammation is a complex physiological process triggered in response to harmful stimuli
1 . It involves cells of the immune system capable of clearing...
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Bioelectric device for effective biofilm inflammation management of dental implants
Dental implant inflammation is primarily caused by oral biofilms, which form within 8 h, particularly at 37 °C, thereby requiring diligent cleaning....
