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Antimicrobials use and infection hospital contacts as proxies of infection exposure at ages 0–2 years and risk of infectious mononucleosis
Infectious mononucleosis (IM) often results from late primary infection with Epstein–Barr virus (EBV). Exposure to EBV at ages 0–2 years from, e.g.,...
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TLR4 896A/G and TLR9 1174G/A polymorphisms are associated with the risk of infectious mononucleosis
Toll-like receptors (TLRs) recognize pathogen-associated molecular patterns and activate innate and adaptive immune responses. Single nucleotide...
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Raman spectroscopy of lymphocytes from patients with the Epstein–Barr virus infection
In this study, Raman spectroscopy is applied to trace lymphocytes activation following contact with the Epstein–Barr virus (EBV) of the herpesvirus...
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Inflammatory and infectious upper respiratory diseases associate with 41 genomic loci and type 2 inflammation
Inflammatory and infectious upper respiratory diseases (ICD-10: J30-J39), such as diseases of the sinonasal tract, pharynx and larynx, are growing...
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Different risk factors distinguish myalgic encephalomyelitis/chronic fatigue syndrome from severe fatigue
Fatigue is a common reason that patients seek medical care. Only a fraction of these patients meet criteria for myalgic encephalomyelitis/chronic...
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Role of IL-27 in Epstein–Barr virus infection revealed by IL-27RA deficiency
Epstein–Barr virus (EBV) infection can engender severe B cell lymphoproliferative diseases
1 ,2 . The primary infection is often asymptomatic or causes...
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Systematic analysis of infectious disease outcomes by age shows lowest severity in school-age children
The COVID-19 pandemic has ignited interest in age-specific manifestations of infection but surprisingly little is known about relative severity of...
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Simple nested Bayesian hypothesis testing for meta-analysis, Cox, Poisson and logistic regression models
Many would probably be content to use Bayesian methodology for hypothesis testing, if it was easy, objective and with trustworthy assumptions. The...
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Smoking and Epstein–Barr virus infection in multiple sclerosis development
It is unclear whether smoking interacts with different aspects of Epstein–Barr virus (EBV) infection with regard to multiple sclerosis (MS) risk. We...
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A genome-wide association study in a large community-based cohort identifies multiple loci associated with susceptibility to bacterial and viral infections
There is limited data on host-specific genetic determinants of susceptibility to bacterial and viral infections. Genome-wide association studies...
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Toxoplasma gondii and multiple sclerosis: a population-based case–control study
According to the hygiene hypothesis, parasites could have a protective role in the development of Multiple Sclerosis (MS). Our aim was to assess the...
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Etiology and clinical characteristics of acute viral hepatitis in South Korea during 2020–2021: a prospective multicenter study
This prospective, 12-center study investigated the etiology and clinical characteristics of acute viral hepatitis (AVH) during 2020–2021 in South...
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Methylation analysis of plasma DNA informs etiologies of Epstein-Barr virus-associated diseases
Epstein-Barr virus (EBV) is associated with a number of diseases, including malignancies. Currently, it is not known whether patients with different...
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Atomic structure of the Epstein-Barr virus portal
Herpesviridae is a vast family of enveloped DNA viruses that includes eight distinct human pathogens, responsible for diseases that range from almost...
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No evidence for an association between alcohol consumption and Multiple Sclerosis risk: a UK Biobank study
Multiple Sclerosis (MS) has been linked to a variety of environmental risk factors, including smoking, Epstein-Barr Virus infection, and childhood...
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Cell activation-based screening of natively paired human T cell receptor repertoires
Adoptive immune therapies based on the transfer of antigen-specific T cells have been used successfully to treat various cancers and viral...
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Ligand-based drug design against Herpes Simplex Virus-1 capsid protein by modification of limonene through in silico approaches
The pharmacological effects of limonene, especially their derivatives, are currently at the forefront of research for drug development and discovery...
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Modelling the dynamics of EBV transmission to inform a vaccine target product profile and future vaccination strategy
Epstein-Barr virus (EBV) is one of the most common human viruses and the cause of pathologies such as infectious mononucleosis (IM) and certain...
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GMean—a semi-supervised GRU and K-mean model for predicting the TF binding site
The transcription factor binding site is a deoxyribonucleic acid sequence that binds to transcription factors. Transcription factors are proteins...
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Tonsillar cytotoxic CD4 T cells are involved in the control of EBV primary infection in children
CD4 T cells play a key role in Epstein Barr virus (EBV) infection, by modulating latent antigen expression, and exhibiting cytotoxic and regulatory...
