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Median raphe serotonergic neurons projecting to the interpeduncular nucleus control preference and aversion
Appropriate processing of reward and aversive information is essential for survival. Although a critical role of serotonergic neurons in the dorsal...
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Lateral habenula glutamatergic neurons projecting to the dorsal raphe nucleus promote aggressive arousal in mice
The dorsal raphe nucleus (DRN) is known to control aggressive behavior in mice. Here, we found that glutamatergic projections from the lateral...
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Aversive stimulus-tuned responses in the CA1 of the dorsal hippocampus
Throughout life animals inevitably encounter unforeseen threatening events. Activity of principal cells in the hippocampus is tuned for locations and...
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Cell type-specific calcium imaging of central sensitization in mouse dorsal horn
Allodynia is a state in which pain is elicited by innocuous stimuli. Capsaicin applied to the skin results in an allodynia that extends to a broad...
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Circadian clock regulator Bmal1 gates axon regeneration via Tet3 epigenetics in mouse sensory neurons
Axon regeneration of dorsal root ganglia (DRG) neurons after peripheral axotomy involves reconfiguration of gene regulatory circuits to establish...
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Distributed processing for value-based choice by prelimbic circuits targeting anterior-posterior dorsal striatal subregions in male mice
Fronto-striatal circuits have been implicated in cognitive control of behavioral output for social and appetitive rewards. The functional diversity...
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Area postrema neurons mediate interleukin-6 function in cancer cachexia
Interleukin-6 (IL-6) has been long considered a key player in cancer cachexia. It is believed that sustained elevation of IL-6 production during...
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Prefrontal cortex neurons encode ambient light intensity differentially across regions and layers
While light can affect emotional and cognitive processes of the medial prefrontal cortex (mPFC), no light-encoding was hitherto identified in this...
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Lateral hypothalamic proenkephalin neurons drive threat-induced overeating associated with a negative emotional state
Psychological stressors, like the nearby presence of a predator, can be strong enough to induce physiological/hormonal alterations, leading to...
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Hyperactivity of indirect pathway-projecting spiny projection neurons promotes compulsive behavior
Compulsive behaviors are a hallmark symptom of obsessive compulsive disorder (OCD). Striatal hyperactivity has been linked to compulsive behavior...
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Parasubthalamic calretinin neurons modulate wakefulness associated with exploration in male mice
The parasubthalamic nucleus (PSTN) is considered to be involved in motivation, feeding and hunting, all of which are highly depending on wakefulness....
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Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity
The wake-active orexin system plays a central role in the dynamic regulation of glucose homeostasis. Here we show orexin receptor type 1 and 2 are...
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Brainstem ADCYAP1+ neurons control multiple aspects of sickness behaviour
Infections induce a set of pleiotropic responses in animals, including anorexia, adipsia, lethargy and changes in temperature, collectively termed...
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Nociceptor neurons affect cancer immunosurveillance
Solid tumours are innervated by nerve fibres that arise from the autonomic and sensory peripheral nervous systems
1 –5 . Whether the neo-innervation of...
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An analgesic pathway from parvocellular oxytocin neurons to the periaqueductal gray in rats
The hypothalamic neuropeptide oxytocin (OT) exerts prominent analgesic effects via central and peripheral action. However, the precise analgesic...
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Enhanced production of mesencephalic dopaminergic neurons from lineage-restricted human undifferentiated stem cells
Current differentiation protocols for generating mesencephalic dopaminergic (mesDA) neurons from human pluripotent stem cells result in grafts...
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Tagging active neurons by soma-targeted Cal-Light
Verifying causal effects of neural circuits is essential for proving a direct circuit-behavior relationship. However, techniques for tagging only...
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Vagal sensory neurons mediate the Bezold–Jarisch reflex and induce syncope
Visceral sensory pathways mediate homeostatic reflexes, the dysfunction of which leads to many neurological disorders
1 . The Bezold–Jarisch reflex...
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Glycolysis inhibition partially resets epilepsy-induced alterations in the dorsal hippocampus-basolateral amygdala circuit involved in anxiety-like behavior
Pharmacoresistant temporal lobe epilepsy affects millions of people around the world with uncontrolled seizures and comorbidities, like anxiety,...
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Immature olfactory sensory neurons provide behaviourally relevant sensory input to the olfactory bulb
Postnatal neurogenesis provides an opportunity to understand how newborn neurons integrate into circuits to restore function. Newborn olfactory...
