Search
Search Results
-
Co-administration of lipopolysaccharide and d-galactosamine induces genotoxicity in mouse liver
The acute liver injury (ALI) and hepatic fibrosis caused by the co-treatment of lipopolysaccharide (LPS)/ d -galactosamine (D-GalN) have been...
-
PANoptosis-like death in acute-on-chronic liver failure injury
The pathogenesis of Acute-on-chronic liver failure (ACLF) involves several forms of cell death, such as pyroptosis, apoptosis, and necroptosis, which...
-
Inhibiting membrane rupture with NINJ1 antibodies limits tissue injury
Plasma membrane rupture (PMR) in dying cells undergoing pyroptosis or apoptosis requires the cell-surface protein NINJ1
1 . PMR releases...
-
Clodronate, an inhibitor of the vesicular nucleotide transporter, ameliorates steatohepatitis and acute liver injury
The vesicular nucleotide transporter (VNUT) is responsible for the vesicular storage and release of ATP from various ATP-secreting cells, and it...
-
Mucus carbohydrate composition correlates with scleractinian coral phylogeny
The mucus surface layer serves vital functions for scleractinian corals and consists mainly of carbohydrates. Its carbohydrate composition has been...
-
Fecal transplantation alleviates acute liver injury in mice through regulating Treg/Th17 cytokines balance
Changes in intestinal microecology during acute liver failure (ALF) directly affect the occurrence and development of the disease. The study aimed to...
-
Spred2 Deficiency Exacerbates D-Galactosamine/Lipopolysaccharide -induced Acute Liver Injury in Mice via Increased Production of TNFα
Acute liver injury (ALI) is characterized by hepatocyte damage and inflammation. In the present study, we examined whether the absence of...
-
Enhanced effect of recombinant human soluble thrombomodulin by ultrasound irradiation in acute liver failure
The administration of recombinant human soluble thrombomodulin (rhsTM) significantly improves liver inflammation and increases the survival rate of...
-
High-efficiency decomposition of eggshell membrane by a keratinase from Meiothermus taiwanensis
Eggshell membrane (ESM), a plentiful biological waste, consists of collagen-like proteins and glycosaminoglycans (GAGs) such as hyaluronic acid (HA)....
-
Bacterial protoplast-derived nanovesicles carrying CRISPR-Cas9 tools re-educate tumor-associated macrophages for enhanced cancer immunotherapy
The CRISPR-Cas9 system offers substantial potential for cancer therapy by enabling precise manipulation of key genes involved in tumorigenesis and...
-
Roles of adenine methylation in the physiology of Lacticaseibacillus paracasei
Lacticaseibacillus paracasei is an economically important bacterial species, used in the food industry and as a probiotic. Here, we investigate the...
-
Metagenomic and culture-dependent analysis of Rhinopithecius bieti gut microbiota and characterization of a novel genus of Sphingobacteriaceae
Culture-dependent and metagenomic binning techniques were employed to gain an insight into the diversification of gut bacteria in Rhinopithecius bieti ...
-
Viscotoxin and lectin content in foliage and fruit of Viscum album L. on the main host trees of Hyrcanian forests
Mistletoe ( Viscum album L.) is a hemiparasitic plant that absorbs water and nutrients from the host tree. Mistletoe contains two groups of cytotoxic,...
-
Evaluating the effects of mefenoxam on taxonomic and functional dynamics of nontarget fungal communities during carrot cultivation
Ridomil Gold SL (45.3% a.i. mefenoxam) is a widely used chemical fungicide for the control of oomycetes. However, its impact on fungal communities...
-
Characterizing the mucin-degrading capacity of the human gut microbiota
Mucin-degrading microbes are known to harbor glycosyl hydrolases (GHs) which cleave specific glycan linkages. Although several microbial species have...
-
A single sulfatase is required to access colonic mucin by a gut bacterium
Humans have co-evolved with a dense community of microbial symbionts that inhabit the lower intestine. In the colon, secreted mucus creates a barrier...
-
Structural and mechanistic insights into the cleavage of clustered O-glycan patches-containing glycoproteins by mucinases of the human gut
Mucinases of human gut bacteria cleave peptide bonds in mucins strictly depending on the presence of neighboring O -glycans. The Akkermansia muciniphila ...
-
Enzymatic conversion of human blood group A kidneys to universal blood group O
ABO blood group compatibility restrictions present the first barrier to donor-recipient matching in kidney transplantation. Here, we present the use...
-
ABO genotype alters the gut microbiota by regulating GalNAc levels in pigs
The composition of the intestinal microbiome varies considerably between individuals and is correlated with health
1 . Understanding the extent to...
-
Bifidobacterium pseudocatenulatum LI09 and Bifidobacterium catenulatum LI10 attenuate D-galactosamine-induced liver injury by modifying the gut microbiota
The gut microbiota is altered in liver diseases, and several probiotics have been shown to reduce the degree of liver damage. We hypothesized that...
