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Blocking MyD88 signaling with MyD88 inhibitor prevents colitis-associated colorectal cancer development by maintaining colonic microbiota homeostasis
Certain intestinal microbiota alterations appear to positively correlate with tumorigenesis of CAC due to the disruption of the balance between the...
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Profiling the colonic mucosal response to fecal microbiota transplantation identifies a role for GBP5 in colitis in humans and mice
Host molecular responses to fecal microbiota transplantation (FMT) in ulcerative colitis are not well understood. Here, we profile the human colonic...
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Sulfated and non-sulfated chondroitin affect the composition and metabolism of human colonic microbiota simulated in an in vitro fermentation system
Chondroitin sulfate (CS) is a family of glycosaminoglycans and have a wide range of applications in dietary supplements and pharmaceutical drugs. In...
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Analysis of colonic mucosa-associated microbiota using endoscopically collected lavage
The bacterial composition of the gut lumen and mucosa is distinct and the mucosa-associated bacteria are thought to play a more critical role in...
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Sex differences in colonic gene expression and fecal microbiota composition in a mouse model of obesity-associated colorectal cancer
This study investigated the sex-specific correlation between obesity and colorectal cancer emphasizing a more pronounced association in males....
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Dietary L-Tryptophan consumption determines the number of colonic regulatory T cells and susceptibility to colitis via GPR15
Environmental factors are the major contributor to the onset of immunological disorders such as ulcerative colitis. However, their identities remain...
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The gut commensal Blautia maintains colonic mucus function under low-fiber consumption through secretion of short-chain fatty acids
Beneficial gut bacteria are indispensable for develo** colonic mucus and fully establishing its protective function against intestinal...
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5-Aminosalicylic acid alters the gut microbiota and altered microbiota transmitted vertically to offspring have protective effects against colitis
Although many therapeutic options are available for inflammatory bowel disease (IBD), 5-aminosalicylic acid (5-ASA) is still the key medication,...
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In vitro digestion and colonic fermentation of phenolic compounds and their antioxidant potential in Australian beach-cast seaweeds
Beach-cast seaweed has recently garnered attention for its nutrient-rich composition, including proteins, carbohydrates, vitamins, minerals, and...
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Impact of habitual chewing on gut motility via microbiota transition
The gut environment, including the microbiota and its metabolites and short-chain fatty acids (SCFA), is essential for health maintenance. It is...
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Deoxycholic acid inducing chronic atrophic gastritis with colonic mucosal lesion correlated to mucosal immune dysfunction in rats
The present study aimed to explore the underlying mechanism of bile reflux-inducing chronic atrophic gastritis (CAG) with colonic mucosal lesion. The...
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Immunoregulatory role of the gut microbiota in inflammatory depression
Inflammatory depression is a treatment-resistant subtype of depression. A causal role of the gut microbiota as a source of low-grade inflammation...
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Mechanoelectronic stimulation of autologous extracellular vesicle biosynthesis implant for gut microbiota modulation
Pathogenic gut microbiota is responsible for a few debilitating gastrointestinal diseases. While the host immune cells do produce extracellular...
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Beneficial metabolic transformations and prebiotic potential of hemp bran and its alcalase hydrolysate, after colonic fermentation in a gut model
Hemp seed bran (HB) is an industrial food byproduct that is generally discarded. Knowledge on the functional capabilities of HB is limited and it is...
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The association of maternal factors with the neonatal microbiota and health
The human microbiome plays a crucial role in human health. However, the influence of maternal factors on the neonatal microbiota remains obscure....
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Non-invasive VOCs detection to monitor the gut microbiota metabolism in-vitro
This work implemented a non-invasive volatile organic compounds (VOCs) monitoring approach to study how food components are metabolised by the gut...
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Microbiota-assisted iron uptake promotes immune tolerance in the intestine
Iron deficiencies are the most common nonenteric syndromes observed in patients with inflammatory bowel disease, but little is known about their...
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MHCII expression on gut macrophages supports T cell homeostasis and is regulated by microbiota and ontogeny
Macrophages are traditionally considered antigen-presenting cells. However, their ability to present antigen and the factors regulating macrophage...
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Ribonuclease 4 functions as an intestinal antimicrobial protein to maintain gut microbiota and metabolite homeostasis
Antimicrobial proteins contribute to host-microbiota interactions and are associated with inflammatory bowel disease (IBD), but our understanding on...
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High-quality metagenome-assembled genomes from proximal colonic microbiomes of synbiotic-treated korean native black pigs reveal changes in functional capacity
Synbiotics are feed supplements with the potential to promote health and productivity in pigs partly, through modulation of the intestinal...
