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No genetic causal association between circulating alpha-tocopherol levels and osteoarthritis, a two-sample Mendelian randomization analysis
The causal association between vitamin E status and osteoarthritis (OA) remains controversial in previous epidemiological studies. We employed a...
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Investigating the causal association between obesity and risk of hepatocellular carcinoma and underlying mechanisms
Obesity is a global health concern and independent risk factor for cancers including hepatocellular carcinoma (HCC). However, evidence on the causal...
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Causal association of calcific aortic valve stenosis and atrial fibrillation: a Mendelian randomization study
Calcific aortic valve stenosis (CAVS) is associated with an increased risk of atrial fibrillation (AF) in observational studies, but whether these...
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Causal association between kynurenine and depression investigated using two-sample mendelian randomization
As research progresses, the intricate metabolic connections between depression and tryptophan, as well as kynurenine (KYN), have become increasingly...
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Transcriptome-wide association analyses reveal the impact of regulatory variants on rice panicle architecture and causal gene regulatory networks
Panicle architecture is a key determinant of rice grain yield and is mainly determined at the 1-2 mm young panicle stage. Here, we investigated the...
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No evident causal association between Helicobacter pylori infection and colorectal cancer: a bidirectional mendelian randomization study
Observational studies have reported a correlation between Helicobacter pylori infection and colorectal cancer (CRC); however, the underlying cause...
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GhostKnockoff inference empowers identification of putative causal variants in genome-wide association studies
Recent advances in genome sequencing and imputation technologies provide an exciting opportunity to comprehensively study the contribution of genetic...
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Causal association between basal metabolic rate and risk of cardiovascular diseases: a univariable and multivariable Mendelian randomization study
Basal metabolic rate (BMR) is associated with cardiovascular health; however, the causal relationship between BMR and the risk of cardiovascular...
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Causal association study of the dynamic development of the metabolic syndrome based on longitudinal data
The dynamic progression of metabolic syndrome (MetS) includes developmental deterioration and reverse recovery; however, the key factors in this...
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Negative causal exploration of systemic sclerosis: a Mendelian randomization analysis
Systemic sclerosis (SSc), also known as scleroderma, is an autoimmune-related connective tissue disease with a complex and unknown pathophysiological...
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Shared genetic risk factors and causal association between psoriasis and coronary artery disease
Psoriasis and coronary artery disease (CAD) are related comorbidities that are well established, but whether a genetic basis underlies this is not...
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Exploring potential causal associations between autoimmune diseases and colorectal cancer using bidirectional Mendelian randomization
Several observational studies have revealed an association between autoimmune diseases (AIDs) and colorectal cancer (CRC), although their causal...
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Large-scale genetic correlation scanning and causal association between deep vein thrombosis and human blood metabolites
Deep vein thrombosis (DVT) refers to the abnormal coagulation of blood in a deep vein. Recently, some studies have found that metabolites are related...
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Discovery of interconnected causal drivers of COVID-19 vaccination intentions in the US using a causal Bayesian network
Holistic interventions to overcome COVID-19 vaccine hesitancy require a system-level understanding of the interconnected causes and mechanisms that...
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Genetic causal role of body mass index in multiple neurological diseases
Body mass index (BMI) is a crucial health indicator for obesity. With the progression of socio-economic status and alterations in lifestyle, an...
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The causal relationship between serum metabolites and acne vulgaris: a Mendelian randomization study
In individuals with acne vulgaris, alterations occur in serum metabolite composition, yet the exact causal link between these metabolites and acne...
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The genetics of falling susceptibility and identification of causal risk factors
Falls represent a huge health and economic burden. Whilst many factors are associated with fall risk (e.g. obesity and physical inactivity) there is...
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Causal effects of genetically predicted endometriosis on breast cancer: a two-sample Mendelian randomization study
This study used a Mendelian randomization (MR) approach to investigate the causal relationship between genetically predicted endometriosis (EMS) and...
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Mendelian randomization analysis revealed potential metabolic causal factors for breast cancer
Observational studies showed that metabolic phenotypes were associated with the risk of develo** breast cancer (BC). However, those results are...
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Unraveling the causal genes and transcriptomic determinants of human telomere length
Telomere length (TL) shortening is a pivotal indicator of biological aging and is associated with many human diseases. The genetic determinates of...
