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Application of the antitussive agents oxelaidin and butamirate as anti-glioma agents
Glioblastoma (GBM) is an aggressive brain tumor with a strong tendency of relapse and resistance to chemotherapy, but we currently lack non-toxic...
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Papaver somniferum in seventeenth century (Italy): archaeotoxicological study on brain and bone samples in patients from a hospital in Milan
In this paper, we present the results of toxicological analyses of preserved brain tissue and bone samples from the remains of the seventeenth...
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Suggestion of a simpler and faster influenza-like illness surveillance system using 2014–2018 claims data in Korea
Influenza is an important public health concern. We propose a new real-time influenza-like illness (ILI) surveillance system that utilizes a...
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Unravelling and reconstructing the biosynthetic pathway of bergenin
Bergenin, a rare C -glycoside of 4- O -methyl gallic acid with pharmacological properties of antitussive and expectorant, is widely used in clinics to...
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Chronic cough relief by allosteric modulation of P2X3 without taste disturbance
P2X receptors are cation channels that sense extracellular ATP. Many therapeutic candidates targeting P2X receptors have begun clinical trials or...
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Early extracorporeal membrane oxygenation as bridge for central airway obstruction patients caused by neck and chest tumors to emergency surgery
Central airway obstruction caused by neck and chest tumors is a very dangerous oncological emergency with high mortality. Unfortunately, there is few...
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Traditional uses, phytochemistry and pharmacology of genus Fritillaria—a review
BackgroundGenus Fritillaria is one among the biggest genera of family Liliaceae comprising of around 130–165 species. Fritillaria is viewed as a...
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Divergent and gram-scale syntheses of (–)-veratramine and (–)-cyclopamine
Veratramine and cyclopamine, two of the most representative members of the isosteroidal alkaloids, are valuable molecules in agricultural and...
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Green extraction and application of yellow natural curcumin colorant from Curcuma aromatica rhizomes for silk dyeing
Green products such as plant tints are becoming more and more well-known worldwide due to their superior biological and ayurvedic properties. In this...
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Quality control of Platycodon grandiflorum (Jacq.) A. DC. based on value chains and food chain analysis
Platycodon grandiflorum (Jacq.) A. DC. has been proposed as a medicine and food homology, thus playing an important role in disease prevention and...
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PtWRKY2, a WRKY transcription factor from Pinellia ternata confers heat tolerance in Arabidopsis
High temperatures are a major stress factor that limit the growth of Pinellia ternata . WRKY proteins widely distribute in plants with the important...
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Dexrazoxane inhibits the growth of esophageal squamous cell carcinoma by attenuating SDCBP/MDA-9/syntenin-mediated EGFR-PI3K-Akt pathway activation
Syndecan-binding protein (SDCBP) was reported to stimulate the advancement of esophageal squamous cell carcinoma (ESCC) and could potentially be a...
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Synthetic polyploidization induces enhanced phytochemical profile and biological activities in Thymus vulgaris L. essential oil
Essential oil from Thymus vulgaris L. has valuable therapeutic potential that is highly desired in pharmaceutical, food, and cosmetic industries....
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Comparative transcriptomes of nine tissues for the Heilongjiang brown frog (Rana amurensis)
The Heilongjiang brown frog ( Rana amurensis ) is widely used in traditional Chinese medicine. In particular, the oviduct and skin have been developed...
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Determination of pholcodine alone or in combination with ephedrine in human plasma using fluorescence spectroscopy
In this study, sensitive, facile, and cost-effective spectrofluorimetric approaches were developed for the determination of pholcodine and ephedrine....
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Increased hospitalizations and economic burden in COPD with bronchiectasis: a nationwide representative study
With the increasing use of computed tomography, bronchiectasis has become a common finding in patients with chronic obstructive pulmonary disease...
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The chloroplast genomes of two medicinal species (Veronica anagallis-aquatica L. and Veronica undulata Wall.) and its comparative analysis with related Veronica species
Veronica anagallis-aquatica L. and Veronica undulata Wall. are widely used ethnomedicinal plants in China. The two species have different clinical...
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Ivy leaves extract EA 575 in the treatment of cough during acute respiratory tract infections: meta-analysis of double-blind, randomized, placebo-controlled trials
Ivy leaves extracts have been used successfully to treat acute cough, and data from well-controlled trials is accumulating. We present a...
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Herbicide resistance status impacts the profile of non-anthocyanin polyphenolics and some phytomedical properties of edible cornflower (Centaurea cyanus L.) flowers
To ensure sufficient food supply worldwide, plants are treated with pesticides to provide protection against pathogens and pests. Herbicides are the...
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Association between chronic idiopathic cough and sensitive skin syndromes is a new argument in favor of common neuropathic pathways: results from a survey on 4050 subjects
Sensitive skin syndrome has a neuropathic origin, which is why it is frequently associated with irritable bowel syndrome. We have looked for a...