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Cell-type-specific Alzheimer’s disease polygenic risk scores are associated with distinct disease processes in Alzheimer’s disease
Many of the Alzheimer’s disease (AD) risk genes are specifically expressed in microglia and astrocytes, but how and when the genetic risk localizing...
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Evidence against a temporal association between cerebrovascular disease and Alzheimer’s disease imaging biomarkers
Whether a relationship exists between cerebrovascular disease and Alzheimer’s disease has been a source of controversy. Evaluation of the temporal...
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Compilation of reported protein changes in the brain in Alzheimer’s disease
Proteomic studies of human Alzheimer’s disease brain tissue have potential to identify protein changes that drive disease, and to identify new drug...
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Cerebrovascular disease emerges with age and Alzheimer’s disease in adults with Down syndrome
Adults with Down syndrome have a genetic form of Alzheimer’s disease (AD) and evidence of cerebrovascular disease across the AD continuum, despite...
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Deep Ensemble learning and quantum machine learning approach for Alzheimer’s disease detection
Alzheimer disease (AD) is among the most chronic neurodegenerative diseases that threaten global public health. The prevalence of Alzheimer disease...
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PTPRS is a novel marker for early Tau pathology and synaptic integrity in Alzheimer’s disease
We examined the role of protein tyrosine phosphatase receptor sigma (PTPRS) in the context of Alzheimer’s disease and synaptic integrity. Publicly...
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Metabolic phenoty** reveals an emerging role of ammonia abnormality in Alzheimer’s disease
The metabolic implications in Alzheimer’s disease (AD) remain poorly understood. Here, we conducted a metabolomics study on a moderately aging...
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Plasma biomarkers predict Alzheimer’s disease before clinical onset in Chinese cohorts
Plasma amyloid-β (Aβ)42, phosphorylated tau (p-tau)181, and neurofilament light chain (NfL) are promising biomarkers of Alzheimer’s disease (AD)....
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Gliovascular transcriptional perturbations in Alzheimer’s disease reveal molecular mechanisms of blood brain barrier dysfunction
To uncover molecular changes underlying blood-brain-barrier dysfunction in Alzheimer’s disease, we performed single nucleus RNA sequencing in 24...
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A single-cell and spatial RNA-seq database for Alzheimer’s disease (ssREAD)
Alzheimer’s Disease (AD) pathology has been increasingly explored through single-cell and single-nucleus RNA-sequencing (scRNA-seq & snRNA-seq) and...
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Human whole-exome genotype data for Alzheimer’s disease
The heterogeneity of the whole-exome sequencing (WES) data generation methods present a challenge to a joint analysis. Here we present a...
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Bearded capuchin monkeys as a model for Alzheimer’s disease
The absence of a natural animal model is one of the main challenges in Alzheimer’s disease research. Despite the challenges of using nonhuman...
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Forecasting individual progression trajectories in Alzheimer’s disease
The anticipation of progression of Alzheimer’s disease (AD) is crucial for evaluations of secondary prevention measures thought to modify the disease...
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APOE4/4 is linked to damaging lipid droplets in Alzheimer’s disease microglia
Several genetic risk factors for Alzheimer’s disease implicate genes involved in lipid metabolism and many of these lipid genes are highly expressed...
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Fatal iatrogenic cerebral β-amyloid-related arteritis in a woman treated with lecanemab for Alzheimer’s disease
We report the case of a 79-year-old woman with Alzheimer’s disease who participated in a Phase III randomized controlled trial called CLARITY-AD...
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Single-cell-led drug repurposing for Alzheimer’s disease
Alzheimer’s disease is the most common form of dementia. Notwithstanding the huge investments in drug development, only one disease-modifying...
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Multi-omic atlas of the parahippocampal gyrus in Alzheimer’s disease
Alzheimer’s disease (AD) is the most common form of dementia worldwide, with a projection of 151 million cases by 2050. Previous genetic studies have...
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Functional variants identify sex-specific genes and pathways in Alzheimer’s Disease
The incidence of Alzheimer’s Disease in females is almost double that of males. To search for sex-specific gene associations, we build a machine...
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Neuron-level explainable AI for Alzheimer’s Disease assessment from fundus images
Alzheimer’s Disease (AD) is a progressive neurodegenerative disease and the leading cause of dementia. Early diagnosis is critical for patients to...
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Elevated CSF GAP-43 is associated with accelerated tau accumulation and spread in Alzheimer’s disease
In Alzheimer’s disease, amyloid-beta (Aβ) triggers the trans-synaptic spread of tau pathology, and aberrant synaptic activity has been shown to...
