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A comprehensive evaluation of pathogenic mutations in primary cutaneous melanomas, including the identification of novel loss-of-function variants
The most common histological subtypes of cutaneous melanoma include superficial spreading and nodular melanoma. However, the spectrum of somatic...
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Studying the connection between SF3B1 and four types of cancer by analyzing networks constructed based on published research
Splicing factor 3B subunit 1 (SF3B1) is the largest component of SF3b protein complex which is involved in the pre-mRNA splicing mechanism. Somatic...
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Clinical and molecular study of radiation-induced gliomas
In this study, we provide a comprehensive clinical and molecular biological characterization of radiation-induced gliomas (RIG), including a risk...
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Genomic analysis as a tool to infer disparate phylogenetic origins of dysembryoplastic neuroepithelial tumors and their satellite lesions
Dysembryoplastic neuroepithelial tumor (DNET) is a low-grade brain tumor commonly associated with drug-resistant epilepsy. About half of DNETs are...
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Real world evidence reveals improved survival outcomes in biliary tract cancer through molecular matched targeted treatment
Biliary tract cancers are rare cancers with poor prognosis due to a lack of therapeutic options, especially after the failure of first-line systemic...
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Modular network mechanism of CCN1-associated resistance to HSV-1-derived oncolytic immunovirotherapies for glioblastomas
Glioblastomas (GBMs) are the most common and lethal primary brain malignancy in adults. Oncolytic virus (OV) immunotherapies selectively kill GBM...
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Comparison of clonal architecture between primary and immunodeficient mouse-engrafted acute myeloid leukemia cells
Patient-derived xenografts (PDX) are widely used as human cancer models. Previous studies demonstrated clonal discordance between PDX and primary...
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The genomic landscape of Vk*MYC myeloma highlights shared pathways of transformation between mice and humans
Multiple myeloma (MM) is a heterogeneous disease characterized by frequent MYC translocations. Sporadic MYC activation in the germinal center of...
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Molecular profiling of 888 pediatric tumors informs future precision trials and data-sharing initiatives in pediatric cancer
To inform clinical trial design and real-world precision pediatric oncology practice, we classified diagnoses, assessed the landscape of mutations,...
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Shared and distinct genetic etiologies for different types of clonal hematopoiesis
Clonal hematopoiesis (CH)—age-related expansion of mutated hematopoietic clones—can differ in frequency and cellular fitness by CH type (e.g.,...
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Integrated clinical and genomic analysis identifies driver events and molecular evolution of colitis-associated cancers
Inflammation has long been recognized to contribute to cancer development, particularly across the gastrointestinal tract. Patients with inflammatory...
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Prediction of IDH and TERT promoter mutations in low-grade glioma from magnetic resonance images using a convolutional neural network
Identification of genotypes is crucial for treatment of glioma. Here, we developed a method to predict tumor genotypes using a pretrained...
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Degradation of D-2-hydroxyglutarate in the presence of isocitrate dehydrogenase mutations
D-2-Hydroxyglutarate (D-2-HG) is regarded as an oncometabolite. It is found at elevated levels in certain malignancies such as acute myeloid...
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Using arterial–venous analysis to characterize cancer metabolic consumption in patients
Understanding tumor metabolism holds the promise of new insights into cancer biology, diagnosis and treatment. To assess human cancer metabolism,...
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Directional integration and pathway enrichment analysis for multi-omics data
Omics techniques generate comprehensive profiles of biomolecules in cells and tissues. However, a holistic understanding of underlying systems...
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Diverse alterations associated with resistance to KRAS(G12C) inhibition
Inactive state-selective KRAS(G12C) inhibitors
1 –8 demonstrate a 30–40% response rate and result in approximately 6-month median progression-free...
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Distinct mutational pattern of T-cell large granular lymphocyte leukemia combined with pure red cell aplasia: low mutational burden of STAT3
T-cell large granular lymphocyte leukemia (T-LGL) is often accompanied by pure red cell aplasia (PRCA). A high depth of next generation sequencing...
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A d-2-hydroxyglutarate biosensor based on specific transcriptional regulator DhdR
d -2-Hydroxyglutarate ( d -2-HG) is a metabolite involved in many physiological metabolic processes. When d -2-HG is aberrantly accumulated due to...
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The genomic landscape of cholangiocarcinoma reveals the disruption of post-transcriptional modifiers
Molecular variation between geographical populations and subtypes indicate potential genomic heterogeneity and novel genomic features within CCA....
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Clinical relevance of somatic mutations in main driver genes detected in gastric cancer patients by next-generation DNA sequencing
Somatic mutation profiling in gastric cancer (GC) enables main driver mutations to be identified and their clinical and prognostic value to be...
