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Integrative blood-based characterization of oxidative mitochondrial DNA damage variants implicates Mexican American’s metabolic risk for develo** Alzheimer’s disease
Alzheimer’s Disease (AD) continues to be a leading cause of death in the US. As the US aging population (ages 65 +) expands, the impact will...
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Intelligent prediction of Alzheimer’s disease via improved multifeature squeeze-and-excitation-dilated residual network
This study aimed to address the issue of larger prediction errors existing in intelligent predictive tasks related to Alzheimer’s disease (AD). A...
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Non-invasive modulation of meningeal lymphatics ameliorates ageing and Alzheimer’s disease-associated pathology and cognition in mice
Meningeal lymphatic vessels (mLVs) have been shown to be involved in amyloid beta (Aβ) clearance, which is considered as a potential therapeutic...
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Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer’s disease
Which isoforms of apolipoprotein E (apoE) we inherit determine our risk of develo** late-onset Alzheimer’s Disease (AD), but the mechanism...
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Life course plasma metabolomic signatures of genetic liability to Alzheimer’s disease
Mechanisms through which most known Alzheimer’s disease (AD) loci operate to increase AD risk remain unclear. Although Apolipoprotein E (APOE) is...
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Basal forebrain volume and metabolism in carriers of the Colombian mutation for autosomal dominant Alzheimer’s disease
We aimed to study atrophy and glucose metabolism of the cholinergic basal forebrain in non-demented mutation carriers for autosomal dominant...
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JUN upregulation drives aberrant transposable element mobilization, associated innate immune response, and impaired neurogenesis in Alzheimer’s disease
Adult neurogenic decline, inflammation, and neurodegeneration are phenotypic hallmarks of Alzheimer’s disease (AD). Mobilization of transposable...
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Blood pressure variability and plasma Alzheimer’s disease biomarkers in older adults
Blood pressure variability is an emerging risk factor for Alzheimer’s disease in older adults, independent of average blood pressure levels. Growing...
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An aging, pathology burden, and glial senescence build-up hypothesis for late onset Alzheimer’s disease
Alzheimer’s disease (AD) predominantly occurs as a late onset (LOAD) form involving neurodegeneration and cognitive decline with progressive memory...
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A single nuclear transcriptomic characterisation of mechanisms responsible for impaired angiogenesis and blood-brain barrier function in Alzheimer’s disease
Brain perfusion and blood-brain barrier (BBB) integrity are reduced early in Alzheimer’s disease (AD). We performed single nucleus RNA sequencing of...
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Properties of odor identification testing in screening for early-stage Alzheimer’s disease
Odor identification (OI) is impaired in the early stages of Alzheimer’s disease (AD). However, data regarding the diagnostic properties of OI tests...
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Resting-state oscillations reveal disturbed excitation–inhibition ratio in Alzheimer’s disease patients
An early disruption of neuronal excitation–inhibition (E–I) balance in preclinical animal models of Alzheimer’s disease (AD) has been frequently...
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Effect of exercise on the hypothalamic–pituitary–gonadal axis in a rat model of Alzheimer’s disease
Hypothalamic–pituitary–gonadal (HPG) axis dysregulation was suggested to play a crucial role in Alzheimer’s disease (AD). This study investigated the...
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Performance of SOBA-AD blood test in discriminating Alzheimer’s disease patients from cognitively unimpaired controls in two independent cohorts
Amyloid-beta (Aβ) toxic oligomers are critical early players in the molecular pathology of Alzheimer’s disease (AD). We have developed a Soluble...
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Downregulation of miR-181c-5p in Alzheimer’s disease weakens the response of microglia to Aβ phagocytosis
Alzheimer’s disease (AD) is an age-associated neurodegenerative disease. Recently, studies have demonstrated the potential involvement of...
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Altered cerebrovascular-CSF coupling in Alzheimer’s Disease measured by functional near-infrared spectroscopy
In-vivo microscopical studies indicate that brain cerebrospinal fluid (CSF) transport driven by blood vessel pulsations is reduced in the early...
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Lipid metabolism transcriptomics of murine microglia in Alzheimer’s disease and neuroinflammation
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the accumulation of amyloid-β (Aβ) plaques followed by intracellular...
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Effect of apolipoprotein genotype and educational attainment on cognitive function in autosomal dominant Alzheimer’s disease
Autosomal dominant Alzheimer’s disease (ADAD) is genetically determined, but variability in age of symptom onset suggests additional factors may...
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Implication of EEG theta/alpha and theta/beta ratio in Alzheimer’s and Lewy body disease
We evaluated the patterns of quantitative electroencephalography (EEG) in patients with Alzheimer’s disease (AD), Lewy body disease (LBD), and mixed...
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Identification of oxidative stress-related genes differentially expressed in Alzheimer’s disease and construction of a hub gene-based diagnostic model
Alzheimer’s disease (AD) is the most prevalent dementia disorder globally, and there are still no effective interventions for slowing or stop** the...
