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A genome-wide atlas of antibiotic susceptibility targets and pathways to tolerance
Detailed knowledge on how bacteria evade antibiotics and eventually develop resistance could open avenues for novel therapeutics and diagnostics. It...
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A synthetic antibiotic class overcoming bacterial multidrug resistance
The dearth of new medicines effective against antibiotic-resistant bacteria presents a growing global public health concern
1 . For more than five...
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CAF08 adjuvant enables single dose protection against respiratory syncytial virus infection in murine newborns
Respiratory syncytial virus is a leading cause of morbidity and mortality in children, due in part to their distinct immune system, characterized by...
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Doxycycline prevents blood–brain barrier dysfunction and microvascular hyperpermeability after traumatic brain injury
The main objective of this study was to determine the cellular and molecular effects of doxycycline on the blood–brain barrier (BBB) and protection...
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Comparison of traditional culture and molecular qPCR for detection of simultaneous carriage of multiple pneumococcal serotypes in African children
S . pneumoniae is a common colonizer of the human nasopharynx in high income and low-middle income countries. Due to limitations of standard culture...
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In vitro influence of PEG functionalized ZnO–CuO nanocomposites on bacterial growth
Polyethyleneglycol-coated biocompatible CuO–ZnO nanocomposites were fabricated hydrothermally varying Zn:Cu ratios as 1:1, 2:1, and 1:2, and their...
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Factor H binding proteins protect division septa on encapsulated Streptococcus pneumoniae against complement C3b deposition and amplification
Streptococcus pneumoniae evades C3-mediated opsonization and effector functions by expressing an immuno-protective polysaccharide capsule and Factor...
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Indoor air surveillance and factors associated with respiratory pathogen detection in community settings in Belgium
Currently, the real-life impact of indoor climate, human behaviour, ventilation and air filtration on respiratory pathogen detection and...
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A novel Streptococcus pneumoniae human challenge model demonstrates Treg lymphocyte recruitment to the infection site
To investigate local tissue responses to infection we have developed a human model of killed Streptococcus pneumoniae challenge by intradermal...
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Moraxella catarrhalis NucM is an entry nuclease involved in extracellular DNA and RNA degradation, cell competence and biofilm scaffolding
Moraxella catarrhalis is a host-adapted bacterial pathogen that causes otitis media and exacerbations of chronic obstructive pulmonary disease. This...
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Targeted small molecule inhibitors blocking the cytolytic effects of pneumolysin and homologous toxins
Pneumolysin (PLY) is a cholesterol-dependent cytolysin (CDC) from Streptococcus pneumoniae , the main cause for bacterial pneumonia. Liberation of PLY...
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Neutrophils and galectin-3 defend mice from lethal bacterial infection and humans from acute respiratory failure
Respiratory infection by Pseudomonas aeruginosa , common in hospitalized immunocompromised and immunocompetent ventilated patients, can be...
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Pneumococcal prophages are diverse, but not without structure or history
Bacteriophages (phages) infect many bacterial species, but little is known about the diversity of phages among the pneumococcus, a leading global...
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Novel LysM motifs for antigen display on lactobacilli for mucosal immunization
We characterized two LysM domains of Limosilactobacillus fermentum , belonging to proteins Acglu (GenBank: KPH22907.1) and Pgb (GenBank: KPH22047.1)...
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Single-cell profiling of the antigen-specific response to BNT162b2 SARS-CoV-2 RNA vaccine
RNA-based vaccines against SARS-CoV-2 have proven critical to limiting COVID-19 disease severity and spread. Cellular mechanisms driving...
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Optimization of cerebrospinal fluid microbial DNA metagenomic sequencing diagnostics
Infection in the central nervous system is a severe condition associated with high morbidity and mortality. Despite ample testing, the majority of...
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Airway epithelial CD47 plays a critical role in inducing influenza virus-mediated bacterial super-infection
Respiratory viral infection increases host susceptibility to secondary bacterial infections, yet the precise dynamics within airway epithelia remain...
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Inherited salt-losing tubulopathies are associated with immunodeficiency due to impaired IL-17 responses
Increased extracellular sodium activates Th17 cells, which provide protection from bacterial and fungal infections. Whilst high salt diets have been...
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Allergic inflammation alters the lung microbiome and hinders synergistic co-infection with H1N1 influenza virus and Streptococcus pneumoniae in C57BL/6 mice
Asthma is a chronic airways condition that can be exacerbated during respiratory infections. Our previous work, together with epidemiologic findings...
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Prevention of EloR/KhpA heterodimerization by introduction of site-specific amino acid substitutions renders the essential elongasome protein PBP2b redundant in Streptococcus pneumoniae
The RNA binding proteins EloR and KhpA are important components of the regulatory network that controls and coordinates cell elongation and division...
