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Bone metastasis detection method based on improving golden jackal optimization using whale optimization algorithm
This paper presents a machine learning-based technique for interpreting bone scintigraphy images, focusing on feature extraction and introducing a...
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Co-delivery of Cas9 mRNA and guide RNAs for editing of LGMN gene represses breast cancer cell metastasis
Legumain (or asparagine endopeptidase/AEP) is a lysosomal cysteine endopeptidase associated with increased invasive and migratory behavior in a...
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TOR1B: a predictor of bone metastasis in breast cancer patients
Recent therapeutic advances in breast cancer (BC) have improved survival outcomes; however, the prognosis for patients with bone metastasis (BM)...
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The spatial transcriptomic landscape of non-small cell lung cancer brain metastasis
Brain metastases (BrMs) are a common occurrence in lung cancer with a dismal outcome. To understand the mechanism of metastasis to inform prognosis...
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METTL3 acetylation impedes cancer metastasis via fine-tuning its nuclear and cytosolic functions
The methyltransferase like 3 (METTL3) has been generally recognized as a nuclear protein bearing oncogenic properties. We find predominantly...
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Association of alpha-fetoprotein and metastasis for small hepatocellular carcinoma: A propensity-matched analysis
Metastasis is crucial for the prognosis of hepatocellular carcinoma (HCC). Distinguishing the potential risk factors for distant metastasis in small...
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A new prediction nomogram of non-sentinel lymph node metastasis in cT1-2 breast cancer patients with positive sentinel lymph nodes
We aimed to analyze the risk factors and construct a new nomogram to predict non-sentinel lymph node (NSLN) metastasis for cT1-2 breast cancer...
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Multidimensional computational study to understand non-coding RNA interactions in breast cancer metastasis
Metastasis is a major breast cancer hallmark due to which tumor cells tend to relocate to regional or distant organs from their organ of origin. This...
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Histone deacetylase inhibitors inhibit lung adenocarcinoma metastasis via HDAC2/YY1 mediated downregulation of Cdh1
Metastasis is a leading cause of mortality in patients with lung adenocarcinoma. Histone deacetylases have emerged as promising targets for...
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Molecular mechanism underlying the increased risk of colorectal cancer metastasis caused by single nucleotide polymorphisms in LI-cadherin gene
LI-cadherin is a member of the cadherin superfamily. LI-cadherin mediates Ca 2+ -dependent cell–cell adhesion through homodimerization. A previous...
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Tumor-infiltrating T cells as a risk factor for lymph node metastasis in patients with submucosal colorectal cancer
Approximately 10% of patients with colorectal cancer with submucosal invasion have lymph node metastasis. Pathological risk factors for lymph node...
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Promoter hypermethylation as a novel regulator of ANO1 expression and function in prostate cancer bone metastasis
Despite growing evidence implicating the calcium-activated chloride channel anoctamin1 (ANO1) in cancer metastasis, its direct impact on the...
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Coadaptation fostered by the SLIT2-ROBO1 axis facilitates liver metastasis of pancreatic ductal adenocarcinoma
To explore the mechanism of coadaptation and the potential drivers of pancreatic ductal adenocarcinoma (PDAC) metastasis to the liver, we study key...
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JAG1 is associated with the prognosis and metastasis in breast cancer
Jagged canonical Notch ligand 1 (JAG1) regulates the progression of many cancers by the Notch signaling pathway, but its role in breast cancer (BC)...
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YAP silencing by RB1 mutation is essential for small-cell lung cancer metastasis
Small cell lung cancer (SCLC) is highly lethal due to its prevalent metastasis. Most SCLCs have inactivating mutations in TP53 and RB1 . We find that...
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TM9SF4 is an F-actin disassembly factor that promotes tumor progression and metastasis
F-actin dynamics is crucial for many fundamental properties of cancer cells, from cell-substrate adhesion to migration, invasion and metastasis....
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A novel algorithm to differentiate between primary lung tumors and distant liver metastasis in lung cancers using an exosome based multi gene biomarker panel
The lack of non-invasive methods for detection of early metastasis is a crucial reason for the poor prognosis of lung cancer (LC) liver metastasis...
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RBFOX2 deregulation promotes pancreatic cancer progression and metastasis through alternative splicing
RNA splicing is an important biological process associated with cancer initiation and progression. However, the contribution of alternative splicing...
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SIRT6 promotes metastasis and relapse in HER2-positive breast cancer
The histone deacetylase sirtuin 6 (SIRT6) has been endowed with anti-cancer capabilities in many tumor types. Here, we investigate the impact of...
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PAFAH1B3 is a KLF9 target gene that promotes proliferation and metastasis in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal human malignancies. Uncontrolled cell proliferation, invasion and migration of...
