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DNA methylation silencing of microRNA gene methylator in the precancerous background mucosa with and without gastric cancer: Analysis of the effects of H. pylori eradication and long-term aspirin use
The risk of gastric cancer (GC) declines after Helicobacter pylori ( H . pylori ) eradication and long-term aspirin use. We evaluated the effects of H . pylori...
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Long-term consequences of one anastomosis gastric bypass on esogastric mucosa in a preclinical rat model
Although bariatric surgery is proven to sustain weight loss in morbidly obese patients, long-term adverse effects have yet to be fully characterized....
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IRF3 prevents colorectal tumorigenesis via inhibiting the nuclear translocation of β-catenin
Occurrence of Colorectal cancer (CRC) is relevant with gut microbiota. However, role of IRF3, a key signaling mediator in innate immune sensing, has...
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Telomere dysfunction activates YAP1 to drive tissue inflammation
Germline telomere maintenance defects are associated with an increased incidence of inflammatory diseases in humans, yet whether and how telomere...
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The Helicobacter pylori Genome Project: insights into H. pylori population structure from analysis of a worldwide collection of complete genomes
Helicobacter pylori , a dominant member of the gastric microbiota, shares co-evolutionary history with humans. This has led to the development of...
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Potential biomarkers and immune characteristics of small bowel adenocarcinoma
Small bowel adenocarcinoma (SBA) is a gastrointestinal malignancy with low incidence but poor prognosis, and its pathogenesis is still unclear. This...
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Differential epithelial and stromal LGR5 expression in ovarian carcinogenesis
Lgr5 has been identified as a marker of the stem/progenitor cells in the murine ovary and oviduct by lineage tracing. However, little is known...
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Changes in inflammatory biomarkers in the nasal mucosal secretion after septoplasty
Deviated nasal septum (DNS) is suggested to be associated with nonspecific inflammation of the nasal mucosa. The authors hypothesized septoplasty may...
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Epithelial expression of Gata4 and Sox2 regulates specification of the squamous–columnar junction via MAPK/ERK signaling in mice
The squamous–columnar junction (SCJ) is a boundary consisting of precisely positioned transitional epithelium between the squamous and columnar...
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Clinical features and shared mechanisms of chronic gastritis and osteoporosis
Chronic gastritis (CG) and osteoporosis (OP) are common and occult diseases in the elderly and the relationship of these two diseases have been...
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Long-term complications and outcomes of augmentation cystoplasty in children with neurogenic bladder
Augmentation cystoplasty (AC) is an effective surgical procedure for patients with neurogenic bladder whenever conservative treatments have failed....
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Multi-omic cross-sectional cohort study of pre-malignant Barrett’s esophagus reveals early structural variation and retrotransposon activity
Barrett’s esophagus is a pre-malignant lesion that can progress to esophageal adenocarcinoma. We perform a multi-omic analysis of pre-cancer samples...
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A retrospective study assessing the acceleration effect of type I Helicobacter pylori infection on the progress of atrophic gastritis
Based on the antibody ty** classification, Helicobacter pylori infection can be divided into type I H. pylori infection and type II H. pylori ...
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Global burden and risk factors of gastritis and duodenitis: an observational trend study from 1990 to 2019
In recent years, there has been a global trend of aging, which has resulted in significant changes to the burden of gastritis and duodenitis (GD)....
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Manic Fringe deficiency imposes Jagged1 addiction to intestinal tumor cells
Delta ligands regulate Notch signaling in normal intestinal stem cells, while Jagged1 activates Notch in intestinal adenomas carrying active...
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Molecular mechanism of BMP signal control by Twisted gastrulation
Twisted gastrulation (TWSG1) is an evolutionarily conserved secreted glycoprotein which controls signaling by Bone Morphogenetic Proteins (BMPs)....
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Spp24 is associated with endocytic signalling, lipid metabolism, and discrimination of tissue integrity for ‘leaky-gut’ in inflammatory bowel disease
Epithelial barrier injury allows contaminants to cross-over into the blood stream and trigger an inflammatory response, contributing to inflammatory...
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Utilization trends for endoscopic ablation therapy and esophagectomy in Barrett’s esophagus from 2005 to 2019
Guidelines have shifted to now recommend endoscopic eradication therapy for Barrett’s esophagus (BE) with low and high-grade dysplasia. Previously,...
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Interaction between retinol intake and ISX rs5755368 polymorphism in colorectal cancer risk: a case–control study in a Korean population
This study aimed to examine whether the ISX rs5755368 genotypes are associated with the effect of dietary retinol consumption on CRC risk. We...
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Extrachromosomal DNA in the cancerous transformation of Barrett’s oesophagus
Oncogene amplification on extrachromosomal DNA (ecDNA) drives the evolution of tumours and their resistance to treatment, and is associated with poor...
