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A proof of concept study on reliability assessment of different metal foil length based piezoelectric sensor for electromechanical impedance techniques
Lead zirconate titanate (PZT) patches gained popularity in structural health monitoring (SHM) for its sensing and cost effective. However, a robust...
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Assessing the oral and suprahyoid muscles in healthy adults using muscle ultrasound to inform the swallowing process: a proof-of-concept study
The oral and suprahyoid muscles are responsible for movements of swallowing. Our study aimed to determine the reproducibility of static and dynamic...
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A proof of principle study using radiopharmaceuticals to quantify and localize container-content interactions in medical syringes
The sorption of drugs onto their contents is a known phenomenon that is difficult to analyse precisely. The purpose of this study was to present a...
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Data mining analyses for precision medicine in acromegaly: a proof of concept
Predicting which acromegaly patients could benefit from somatostatin receptor ligands (SRL) is a must for personalized medicine. Although many...
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Deep learning-based diffusion tensor image generation model: a proof-of-concept study
This study created an image-to-image translation model that synthesizes diffusion tensor images (DTI) from conventional diffusion weighted images,...
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Customized virtual reality naturalistic scenarios promoting engagement and relaxation in patients with cognitive impairment: a proof-of-concept mixed-methods study
Being immersed in a natural context has a beneficial and pervasive impact on well-being. Virtual Reality (VR) is a technology that can help expose...
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ENHANCE proof-of-concept three-arm randomized trial: effects of reaching training of the hemiparetic upper limb restricted to the spasticity-free elbow range
Post-stroke motor recovery processes remain unknown. Timescales and patterns of upper-limb (UL) recovery suggest a major impact of biological...
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Development of a calculated panel reactive antibody calculator for the United Arab Emirates: a proof of concept study
Calculated panel reactive antibody (CPRA) is used to help increase sensitized patient’s access to transplantation. United Arab Emirates (UAE) has a...
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Non-targeted metabolomics aids in sex pheromone identification: a proof-of-concept study with the triangulate cobweb spider, Steatoda triangulosa
Targeted metabolomics has been widely used in pheromone research but may miss pheromone components in study organisms that produce pheromones in...
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Peptidome profiling for the immunological stratification in sepsis: a proof of concept study
Sepsis has been called the graveyard of pharmaceutical companies due to the numerous failed clinical trials. The lack of tools to monitor the...
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MRI-based radiomics for predicting histology in malignant salivary gland tumors: methodology and “proof of principle”
Defining the exact histological features of salivary gland malignancies before treatment remains an unsolved problem that compromises the ability to...
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Interventional neurorehabilitation for promoting functional recovery post-craniotomy: a proof-of-concept
The human brain is a highly plastic ‘complex’ network—it is highly resilient to damage and capable of self-reorganisation after a large perturbation....
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Fractal analysis of 4D dynamic myocardial stress-CT perfusion imaging differentiates micro- and macrovascular ischemia in a multi-center proof-of-concept study
Fractal analysis of dynamic, four-dimensional computed tomography myocardial perfusion (4D-CTP) imaging might have potential for noninvasive...
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Proof of concept for develo** novel feeds for cattle from wasted food and crop biomass to enhance agri-food system efficiency
Modern agri-food systems generate large amounts of crop-based biomass that are unfit for direct human consumption but potentially suitable for...
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A proof-of-principle for decontamination of transplantation kidney through UV-C exposition of the perfusate solution
Kidney transplantation is a common yet highly demanding medical procedure worldwide, enhancing the quality of life for patients with chronic kidney...
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A proof of concept study on real-time LiMAx CYP1A2 liver function assessment of donor grafts during normothermic machine perfusion
No single reliable parameter exists to assess liver graft function of extended criteria donors during ex-vivo normothermic machine perfusion (NMP)....
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A proof-of-concept study to investigate the efficacy of heat-inactivated autovaccines in Mycobacterium caprae experimentally challenged goats
This study aimed to assess the efficacy of a heat-inactivated Mycobacterium caprae (HIMC) vaccine in goats experimentally challenged with the same...
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MR-orthopantomography in operative dentistry and oral and maxillofacial surgery: a proof of concept study
This prospective study aimed to present, compare, and evaluate the suitability of five different magnetic resonance imaging (MRI) protocols (3D...
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Development of a new screening method for faster kinship analyses in mass disasters: a proof of concept study
Kinship analysis in forensics is based on the calculation of the respective kinship indices. However, this calculation is only possible when the...
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Differentiation of patients with mild cognitive impairment and healthy controls based on computer assisted hand movement analysis: a proof-of-concept study
Mild cognitive impairment (MCI) is the prodromal phase of dementia, and it is highly underdiagnosed in the community. We aimed to develop an...
