Search
Search Results
-
Impact of varying social experiences during life history on behaviour, gene expression, and vasopressin receptor gene methylation in mice
Both negative and positive social experiences during sensitive life phases profoundly shape brain and behaviour. Current research is therefore...
-
Ovine multiparity is associated with diminished vaginal muscularis, increased elastic fibres and vaginal wall weakness: implication for pelvic organ prolapse
Pelvic Organ Prolapse (POP) is a major clinical burden affecting 25% of women, with vaginal delivery a major contributing factor. We hypothesised...
-
Stem and progenitor cell division kinetics during postnatal mouse mammary gland development
The cycling properties of mammary stem and progenitor cells is not well understood. To determine the division properties of these cells, we...
-
Sex-specific regulation of follicle-stimulating hormone secretion by synaptotagmin 9
The anterior pituitary releases six different hormones that control virtually all aspects of vertebrate physiology, yet the molecular mechanisms...
-
Opposite-sex attraction in male mice requires testosterone-dependent regulation of adult olfactory bulb neurogenesis
Opposite-sex attraction in most mammals depends on the fine-tuned integration of pheromonal stimuli with gonadal hormones in the brain circuits...
-
Ovarian proteomic study reveals the possible molecular mechanism for hyperprolificacy of Small Tail Han sheep
Small Tail Han sheep is a widely bred farm animal in China which has attracted lots of attention due to their high prolificacy and year-round estrus....
-
A sexually dimorphic hypothalamic circuit controls maternal care and oxytocin secretion
It is commonly assumed, but has rarely been demonstrated
1 ,2 , that sex differences in behaviour arise from sexual dimorphism in the underlying neural...
-
Histological and transcriptome analyses of testes from Duroc and Meishan boars
Meishan boars are known for their early sexual maturity. However, they exhibit a significantly smaller testicular size and a reduced proportion of...
-
Characterization of the Transcriptional Complexity of the Receptive and Pre-receptive Endometria of Dairy Goats
Endometrium receptivity is essential for successful embryo implantation in mammals. However, the lack of genetic information remains an obstacle to...
-
Vaginal type-II mucosa is an inductive site for primary CD8+ T-cell mucosal immunity
The structured lymphoid tissues are considered the only inductive sites where primary T-cell immune responses occur. The naïve T cells in structured...
-
Ultrasonography of wallaby prenatal development shows that the climb to the pouch begins in utero
Marsupials have a functional placenta for a shorter period of time compared to that of eutherian species and their altricial young reach the teats...
-
A genetically female brain is required for a regular reproductive cycle in chicken brain chimeras
Sexual differentiation leads to structural and behavioural differences between males and females. Here we investigate the intrinsic sex identity of...
-
Disrupted erythropoietin signalling promotes obesity and alters hypothalamus proopiomelanocortin production
Although erythropoietin (Epo) is the cytokine known to regulate erythropoiesis, erythropoietin receptor (EpoR) expression and associated activity...
-
Progesterone induces adult mammary stem cell expansion
Reproductive history is the strongest risk factor for breast cancer after age, genetics and breast density
1 ,2 . Increased breast cancer risk is...
-
Embryo implantation: A time for recalling and forwarding
The success of embryo implantation is a critical step towards further embryo development and pregnancy outcome. The observations and investigations...
-
-
Pheromonal communication in vertebrates
Recent insights have revolutionized our understanding of the importance of chemical signals in influencing vertebrate behaviour. Previously unknown...
-
Structure of human follicle-stimulating hormone in complex with its receptor
Follicle-stimulating hormone (FSH) is central to reproduction in mammals. It acts through a G-protein-coupled receptor on the surface of target cells...
-
STAT3 signalling is required for leptin regulation of energy balance but not reproduction
Secretion of leptin from adipocytes communicates body energy status to the brain by activating the leptin receptor long form (LRb). LRb regulates...
-
IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
Studies in invertebrates have led to the identification of a number of genes that regulate lifespan, some of which encode components of the insulin...
