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Selective activator of human ClpP triggers cell cycle arrest to inhibit lung squamous cell carcinoma
Chemo-activation of mitochondrial ClpP exhibits promising anticancer properties. However, we are currently unaware of any studies using selective and...
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Single-cell allele-specific expression analysis reveals dynamic and cell-type-specific regulatory effects
Differential allele-specific expression (ASE) is a powerful tool to study context-specific cis-regulation of gene expression. Such effects can...
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CD8+ T cell-derived Fgl2 regulates immunity in a cell-autonomous manner via ligation of FcγRIIB
The regulatory circuits dictating CD8 + T cell responsiveness versus exhaustion during anti-tumor immunity are incompletely understood. Here we report...
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A chemical proteomics approach for global map** of functional lysines on cell surface of living cell
Cell surface proteins are responsible for many crucial physiological roles, and they are also the major category of drug targets as the majority of...
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Dendritic cell-targeted therapy expands CD8 T cell responses to bona-fide neoantigens in lung tumors
Cross-presentation by type 1 DCs (cDC1) is critical to induce and sustain antitumoral CD8 T cell responses to model antigens, in various tumor...
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Revealing brain cell-stratified causality through dissecting causal variants according to their cell-type-specific effects on gene expression
The human brain has been implicated in the pathogenesis of several complex diseases. Taking advantage of single-cell techniques, genome-wide...
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Hypoxia suppresses glucose-induced increases in collective cell migration in vascular endothelial cell monolayers
Blood glucose levels fluctuate during daily life, and the oxygen concentration is low compared to the atmosphere. Vascular endothelial cells (ECs)...
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Single-cell transcriptomics uncovers EGFR signaling-mediated gastric progenitor cell differentiation in stomach homeostasis
Defects in gastric progenitor cell differentiation are associated with various gastric disorders, including atrophic gastritis, intestinal...
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Deciphering anoikis resistance and identifying prognostic biomarkers in clear cell renal cell carcinoma epithelial cells
This study tackles the persistent prognostic and management challenges of clear cell renal cell carcinoma (ccRCC), despite advancements in multimodal...
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Exploration of cell state heterogeneity using single-cell proteomics through sensitivity-tailored data-independent acquisition
Single-cell resolution analysis of complex biological tissues is fundamental to capture cell-state heterogeneity and distinct cellular signaling...
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Effect of CHST11, a novel biomarker, on the biological functionalities of clear cell renal cell carcinoma
Clear cell renal cell carcinoma (ccRCC) is a common malignant tumor, and the role of carbohydrate sulfotransferase 11 (CHST11) in this cancer remains...
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scBridge embraces cell heterogeneity in single-cell RNA-seq and ATAC-seq data integration
Single-cell multi-omics data integration aims to reduce the omics difference while kee** the cell type difference. However, it is daunting to model...
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Cellcano: supervised cell type identification for single cell ATAC-seq data
Computational cell type identification is a fundamental step in single-cell omics data analysis. Supervised cellty** methods have gained increasing...
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Single-cell resolution characterization of myeloid-derived cell states with implication in cancer outcome
Tumor-associated myeloid-derived cells (MDCs) significantly impact cancer prognosis and treatment responses due to their remarkable plasticity and...
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Automated single-cell proteomics providing sufficient proteome depth to study complex biology beyond cell type classifications
The recent technological and computational advances in mass spectrometry-based single-cell proteomics have pushed the boundaries of sensitivity and...
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Cancer cell genetics sha** of the tumor microenvironment reveals myeloid cell-centric exploitable vulnerabilities in hepatocellular carcinoma
Myeloid cells are abundant and plastic immune cell subsets in the liver, to which pro-tumorigenic, inflammatory and immunosuppressive roles have been...
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Microfluidic devices for precise measurements of cell directionality reveal a role for glutamine during cell migration
Cancer cells that migrate from tumors into surrounding tissues are responsible for cancer dissemination through the body. Microfluidic devices have...
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Proteogenomics of clear cell renal cell carcinoma response to tyrosine kinase inhibitor
The tyrosine kinase inhibitor (TKI) Sunitinib is one the therapies approved for advanced renal cell carcinoma. Here, we undertake proteogenomic...
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Cell-attribute aware community detection improves differential abundance testing from single-cell RNA-Seq data
Variations of cell-type proportions within tissues could be informative of biological aging and disease risk. Single-cell RNA-sequencing offers the...
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Robust map** of spatiotemporal trajectories and cell–cell interactions in healthy and diseased tissues
Spatial transcriptomics (ST) technologies generate multiple data types from biological samples, namely gene expression, physical distance between...
