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Non-coding RNA-related FCGBP downregulation in head and neck squamous cell carcinoma: a novel biomarker for predicting paclitaxel resistance and immunosuppressive microenvironment
In head and neck squamous cell carcinoma (HNSC), chemoresistance is a major reason for poor prognosis. Nevertheless, there is a lack of validated...
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Comprehensive analysis of mitophagy in HPV-related head and neck squamous cell carcinoma
Head and neck squamous cell carcinoma (HNSCC) is a common tumour type in otorhinolaryngology, and its occurrence is related to long-term exposure to...
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A retrospective analysis of tumor infiltrating lymphocytes in head and neck squamous cell carcinoma patients treated with nivolumab
Nivolumab, an immune checkpoint inhibitor is the first-line therapy for platinum-resistant recurrent/metastatic head and neck cancer, and highly...
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Impact of tumor burden on survival in patients with recurrent or metastatic head and neck cancer treated with immune checkpoint inhibitors
Immune checkpoint inhibitors (ICIs) have become the standard treatment for recurrent or metastatic head and neck cancer (RM-HNC). However, many...
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Cross-institutional outcome prediction for head and neck cancer patients using self-attention neural networks
In radiation oncology, predicting patient risk stratification allows specialization of therapy intensification as well as selecting between systemic...
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Urokinase-type plasminogen activator receptor (uPAR) assessed by liquid biopsies and PET/CT for prognostication in head and neck cancer patients
Strong prognostic biomarkers are lacking regarding the stratification of treatment and surveillance regimens in head and neck squamous cell carcinoma...
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Investigating diagnostic potential of long non-coding RNAs in head and neck squamous cell carcinoma using TCGA database and clinical specimens
Head and neck squamous cell carcinoma (HNSCC) is a prevalent and prognostically challenging cancer worldwide. The role of long non-coding RNAs...
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Identify and validate circadian regulators as potential prognostic markers and immune infiltrates in head and neck squamous cell carcinoma
Head and neck squamous cell carcinoma (HNSCC) is a heterogeneity pathological malignant cancer with leading causes of morbidity and mortality. EGFR...
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Improvement in the neutron beam collimation for application in boron neutron capture therapy of the head and neck region
In June 2020, the Japanese government approved boron neutron capture therapy for the treatment of head and neck cancer. The treatment is usually...
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Alterations in meibomian glands in patients treated with intensity-modulated radiotherapy for head and neck cancer
Patients undergoing intensity-modulated radiotherapy (IMRT) for head and neck cancer may have increased incidence of dry eye disease and the exact...
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Identification of PANoptosis-related biomarkers and analysis of prognostic values in head and neck squamous cell carcinoma
PANoptosis plays a crucial role in cancer initiation and progression. However, the roles of PANoptosis-related genes (PARGs) in the prognosis and...
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Recombinant immunotoxin induces tumor intrinsic STING signaling against head and neck squamous cell carcinoma
The innate immune stimulator of interferon genes (STING) pathway is known to activate type I interferons (IFN-I) and participate in generating...
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CYP4F12 is a potential biomarker and inhibits cell migration of head and neck squamous cell carcinoma via EMT pathway
Head and neck squamous cell carcinoma (HNSC) is the most common malignant tumor of head and neck. Due to the insidious nature of HNSC and the lack of...
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EphB4 and ephrinB2 act in opposition in the head and neck tumor microenvironment
Differential outcomes of EphB4-ephrinB2 signaling offers formidable challenge for the development of cancer therapeutics. Here, we interrogate the...
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Association of circulating tumor HPV16DNA levels and quantitative PET parameters in patients with HPV-positive head and neck squamous cell carcinoma
Circulating tumor DNA (ctDNA), which circulates in the blood after being shed from cancer cells in the body, has recently gained attention as an...
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Patient-derived head and neck tumor slice cultures: a versatile tool to study oncolytic virus action
Head and neck cancer etiology and architecture is quite diverse and complex, impeding the prediction whether a patient could respond to a particular...
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Swallowing, nutritional status, and salivary flow in patients after head and neck cancer treatment, a pilot study
Determine the relationship between swallowing function, nutritional status, and salivary flow in patients after head and neck cancer treatment. This...
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Effects of ischemic conditioning on head and neck free flap oxygenation: a randomized controlled trial
Flap failure after microvascular reconstructive surgery is a rare but devastating complication caused by reperfusion injury and tissue hypoperfusion....
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Tumor-infiltrating immune cells and survival in head and neck squamous cell carcinoma: a retrospective computational study
The immune infiltration profiles of the tumor microenvironment have effects on the prognosis of head and neck squamous cell carcinoma (HNSCC)....
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Randomized phase II study of preoperative afatinib in untreated head and neck cancers: predictive and pharmacodynamic biomarkers of activity
There is no strong and reliable predictive biomarker in head and neck squamous cell carcinoma (HNSCC) for EGFR inhibitors. We aimed to identify...
