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SIGNET: transcriptome-wide causal inference for gene regulatory networks
Gene regulation plays an important role in understanding the mechanisms of human biology and diseases. However, inferring causal relationships...
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Identifying the causal relationship between immune factors and osteonecrosis: a two-sample Mendelian randomization study
A wealth of evidence intimates a profound connection between the immune system and osteonecrosis, albeit the specific immune factors underlying this...
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Exploring the causal relationship between inflammatory cytokines and migraine: a bidirectional, two-sample Mendelian randomization study
To further evaluate the causal relationships between inflammatory cytokines and migraine, we conducted a bidirectional, two-sample Mendelian...
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The causal effects of leisure screen time on irritable bowel syndrome risk from a Mendelian randomization study
Associations between leisure sedentary behavior (especially leisure screen time, LST) and irritable bowel syndrome (IBS) have been reported, but...
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Exploring the causal relationship between B lymphocytes and Parkinson’s disease: a bidirectional, two-sample Mendelian randomization study
Parkinson’s disease (PD) is a neurodegenerative disorder with extensive involvement of motor symptoms, imposing a heavy economic burden on patients...
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Investigation of genetic variants and causal biomarkers associated with brain aging
Delta age is a biomarker of brain aging that captures differences between the chronological age and the predicted biological brain age. Using...
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Application of advanced causal analyses to identify processes governing secondary organic aerosols
Understanding how different physical and chemical atmospheric processes affect the formation of fine particles has been a persistent challenge....
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The causal relationship between psoriasis, psoriatic arthritis, and inflammatory bowel diseases
Psoriasis is more common in patients with inflammatory bowel disease (IBD) than in the general population. Similarly, patients with psoriasis or...
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Assessing causal relationships between gut microbiota and psoriasis: evidence from two sample Mendelian randomization analysis
Mounting data hints that the gut microbiota's role may be pivotal in understanding the emergence of psoriasis. However, discerning a direct causal...
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A Mendelian randomization study on causal effects of inflammatory bowel disease on the risk of erectile dysfunction
This study aimed to evaluate the causal effects of inflammatory bowel disease (IBD) and erectile dysfunction (ED) using Mendelian randomization (MR)....
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Absence of causal association between Vitamin D and bone mineral density across the lifespan: a Mendelian randomization study
Vitamin D deficiency is a candidate risk factor for osteoporosis, characterized by decreased bone mineral density (BMD). We performed this two-sample...
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The causal effect of Helicobacter pylori infection on coronary heart disease is mediated by the body mass index: a Mendelian randomization study
The association between Helicobacter pylori (H. pylori) infection and coronary heart disease (CHD) remains controversial, with an unclear causal...
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Method comparison and estimation of causal effects of insomnia on health outcomes in a survey sampled population
Applying causal inference methods, such as weighting and matching methods, to a survey sampled population requires properly incorporating the survey...
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Causal role of immune cells on cervical cancer onset revealed by two-sample Mendelian randomization study
Cervical cancer (CC) is a prevalent gynecological cancer worldwide that significantly impacts the quality of life and the physical and mental...
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Automating psychological hypothesis generation with AI: when large language models meet causal graph
Leveraging the synergy between causal knowledge graphs and a large language model (LLM), our study introduces a groundbreaking approach for...
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Causal influence of muscle weakness on cardiometabolic diseases and osteoporosis
The causal roles of muscle weakness in cardiometabolic diseases and osteoporosis remain elusive. This two-sample Mendelian randomization (MR) study...
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Prediction and causal inference of cardiovascular and cerebrovascular diseases based on lifestyle questionnaires
Cardiovascular and cerebrovascular diseases (CCVD) are prominent mortality causes in Japan, necessitating effective preventative measures, early...
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Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma
Primary open-angle glaucoma (POAG), characterized by retinal ganglion cell death, is a leading cause of irreversible blindness worldwide. However,...
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Genetic evidence for causal effects of leukocyte counts on risk for rheumatoid arthritis
Rheumatoid arthritis (RA) is an autoimmune disease characterized by the accumulation of leukocytes and inflammatory mediators within the synovial...
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Integrating leiomyoma genetics, epigenomics, and single-cell transcriptomics reveals causal genetic variants, genes, and cell types
Uterine fibroids (UF), that can disrupt normal uterine function and cause significant physical and psychological health problems, are observed in...
