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Non-fluorescent transient states of tyrosine as a basis for label-free protein conformation and interaction studies
The amino acids tryptophan, tyrosine, and phenylalanine have been extensively used for different label-free protein studies, based on the intensity,...
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Dopamine signaling enriched striatal gene set predicts striatal dopamine synthesis and physiological activity in vivo
The polygenic architecture of schizophrenia implicates several molecular pathways involved in synaptic function. However, it is unclear how polygenic...
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Deciphering the genetic basis of male fertility in Italian Brown Swiss dairy cattle
Improving reproductive performance remains a major goal in dairy cattle worldwide. Service sire has been recognized as an important factor affecting...
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Structural basis for the activation of a compact CRISPR-Cas13 nuclease
The CRISPR-Cas13 ribonucleases have been widely applied for RNA knockdown and transcriptional modulation owing to their high programmability and...
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Structural basis of organic cation transporter-3 inhibition
Organic cation transporters (OCTs) facilitate the translocation of catecholamines, drugs and xenobiotics across the plasma membrane in various...
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Structural basis for dimerization of a paramyxovirus polymerase complex
The transcription and replication processes of non-segmented, negative-strand RNA viruses (nsNSVs) are catalyzed by a multi-functional polymerase...
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Generalized Regressed Exponential Estimator for Estimation of Mean Under Neutrosophic Ranked Set Sampling
This manuscript uses neutrosophic ranked set sampling to handle the data involving uncertainty and proposed generalized regressed exponential...
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A reduction from an LWE problem to maximum independent set problems
The learning with errors (LWE) problem is a problem derived from machine learning that is believed to be intractable for quantum computers. This...
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A hybridized red deer and rough set clinical information retrieval system for hepatitis B diagnosis
Healthcare is a big concern in the current booming population. Many approaches for improving health are imposed, such as early disease...
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The molecular basis of sugar detection by an insect taste receptor
Animals crave sugars because of their energy potential and the pleasurable sensation of tasting sweetness. Yet all sugars are not metabolically...
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A neurophysiological basis for aperiodic EEG and the background spectral trend
Electroencephalograms (EEGs) display a mixture of rhythmic and broadband fluctuations, the latter manifesting as an apparent 1/f spectral trend....
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Structural basis of amine odorant perception by a mammal olfactory receptor
Odorants are detected as smell in the nasal epithelium of mammals by two G-protein-coupled receptor families, the odorant receptors and the trace...
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Structural basis of sensory receptor evolution in octopus
Chemotactile receptors (CRs) are a cephalopod-specific innovation that allow octopuses to explore the seafloor via ‘taste by touch’
1 . CRs diverged...
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A Data Set of Signals from an Antenna for Detection of Partial Discharges in Overhead Insulated Power Line
We introduce a data set obtained via a contactless antenna method for detecting partial discharges in XLPE-covered conductors used in medium-voltage...
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Structural basis for intrinsic transcription termination
Efficient and accurate termination is required for gene transcription in all living organisms
1 ,2 . Cellular RNA polymerases in both bacteria and...
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Cryo-EM reveals the molecular basis of laminin polymerization and LN-lamininopathies
Laminin polymerization is the major step in basement membranes assembly. Its failures cause laminin N-terminal domain lamininopathies including...
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Molecular basis of TASL recruitment by the peptide/histidine transporter 1, PHT1
PHT1 is a histidine /oligopeptide transporter with an essential role in Toll-like receptor innate immune responses. It can act as a receptor by...
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Pro-phagocytic function and structural basis of GPR84 signaling
GPR84 is a unique orphan G protein-coupled receptor (GPCR) that can be activated by endogenous medium-chain fatty acids (MCFAs). The signaling of...
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Structural basis of ribosomal 30S subunit degradation by RNase R
Protein synthesis is a major energy-consuming process of the cell that requires the controlled production
1 –3 and turnover4 ,5 of ribosomes. Although...
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Structural basis for peroxidase encapsulation inside the encapsulin from the Gram-negative pathogen Klebsiella pneumoniae
Encapsulins are self-assembling protein nanocompartments capable of selectively encapsulating dedicated cargo proteins, including enzymes involved in...
