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Inhibition of fatty acid oxidation enables heart regeneration in adult mice
Postnatal maturation of cardiomyocytes is characterized by a metabolic switch from glycolysis to fatty acid oxidation, chromatin reconfiguration and...
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Twist2 contributes to skin regeneration and hair follicle formation in mouse fetuses
Unlike adult mammalian wounds, early embryonic mouse skin wounds completely regenerate and heal without scars. Analysis of the underlying molecular...
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Apoptotic dysregulation mediates stem cell competition and tissue regeneration
Since adult stem cells are responsible for replenishing tissues throughout life, it is vital to understand how failure to undergo apoptosis can...
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Platelet-derived chemokines promote skeletal muscle regeneration by guiding neutrophil recruitment to injured muscles
Skeletal muscle regeneration involves coordinated interactions between different cell types. Injection of platelet-rich plasma is circumstantially...
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Elastic porous microspheres/extracellular matrix hydrogel injectable composites releasing dual bio-factors enable tissue regeneration
Injectable biomaterials have garnered increasing attention for their potential and beneficial applications in minimally invasive surgical procedures...
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Circadian clock regulator Bmal1 gates axon regeneration via Tet3 epigenetics in mouse sensory neurons
Axon regeneration of dorsal root ganglia (DRG) neurons after peripheral axotomy involves reconfiguration of gene regulatory circuits to establish...
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Small leucine-rich proteoglycans inhibit CNS regeneration by modifying the structural and mechanical properties of the lesion environment
Extracellular matrix (ECM) deposition after central nervous system (CNS) injury leads to inhibitory scarring in humans and other mammals, whereas it...
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Glia instruct axon regeneration via a ternary modulation of neuronal calcium channels in Drosophila
A neuron’s regenerative capacity is governed by its intrinsic and extrinsic environment. Both peripheral and central neurons exhibit...
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Ultra-durable cell-free bioactive hydrogel with fast shape memory and on-demand drug release for cartilage regeneration
Osteoarthritis is a worldwide prevalent disease that imposes a significant socioeconomic burden on individuals and healthcare systems. Achieving...
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Oxidation-treated carbon nanotube yarns accelerate neurite outgrowth and induce axonal regeneration in peripheral nerve defect
Carbon nanotubes (CNTs) have the potential to promote peripheral nerve regeneration, although with limited capacity and foreign body reaction. This...
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Tracing immune cells around biomaterials with spatial anchors during large-scale wound regeneration
Skin scarring devoid of dermal appendages after severe trauma has unfavorable effects on aesthetic and physiological functions. Here we present a...
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Experimental insights into electrocatalytic [Cp*Rh(bpy)Cl]+ mediated NADH regeneration
NADH plays a crucial role in many enzymatically catalysed reactions. Due to the high costs of NADH a regeneration mechanism of this cofactor can...
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Dual-energy computed tomography and micro-computed tomography for assessing bone regeneration in a rabbit tibia model
To gain a more meaningful understanding of bone regeneration, it is essential to select an appropriate assessment method. Micro-computed tomography...
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Glucagon-like peptide-1 and glucagon-like peptide-2 regulation during human liver regeneration
Accumulating evidence suggests that metabolic demands of the regenerating liver are met via lipid metabolism and critical regulators of this process....
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Fabrication of ECM protein coated hollow collagen channels to study peripheral nerve regeneration
Peripheral nerve injury is a prevalent clinical problem that often leads to lifelong disability and reduced quality of life. Although peripheral...
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Construction of ultrasonically treated collagen/silk fibroin composite scaffolds to induce cartilage regeneration
A novel tissue-specific functional tissue engineering scaffold for cartilage repair should have a three-dimensional structure, good biosafety and...
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Hedgehog signaling via its ligand DHH acts as cell fate determinant during skeletal muscle regeneration
Successful muscle regeneration relies on the interplay of multiple cell populations. However, the signals required for this coordinated intercellular...
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Molecular co-assembled strategy tuning protein conformation for cartilage regeneration
The assembly of oligopeptide and polypeptide molecules can reconstruct various ordered advanced structures through intermolecular interactions to...
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Establishment of an efficient regeneration system of ‘ZiKui’ tea with hypocotyl as explants
Zikui ( Camellia sinensis cv. Zikui ) is a recently discovered cultivar of local purple tea in Guizhou, China. It is a purple leaf bud mutation...
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Enhanced bone regeneration in rat calvarial defects through BMP2 release from engineered poly(ethylene glycol) hydrogels
The clinical standard therapy for large bone defects, typically addressed through autograft or allograft donor tissue, faces significant limitations....
