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Genome-wide association analyses of invasive pneumococcal isolates identify a missense bacterial mutation associated with meningitis
Bacterial mutations predisposing pneumococcus to causing meningitis, a more severe form of invasive pneumococcal disease (IPD), are largely unknown....
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Hepcidin discriminates sepsis from other critical illness at admission to intensive care
Initial differential diagnosis and prognosis for patients admitted to intensive care with suspected sepsis remain arduous. Hepcidin has emerged as a...
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Surveillance of hemodialysis related infections: a prospective multicenter study
As in many countries, there is neither a surveillance system nor a study to reveal the hemodialysis (HD) related infection rates in Turkey. We aimed...
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The airway microbiota of neonates colonized with asthma-associated pathogenic bacteria
Culture techniques have associated colonization with pathogenic bacteria in the airways of neonates with later risk of childhood asthma, whereas more...
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Dominance of vaccine serotypes in pediatric invasive pneumococcal infections in Portugal (2012–2015)
We evaluated the impact of continued 13-valent pneumococcal conjugate vaccine (PCV13) use in the private market (uptake of 61%) in pediatric invasive...
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The divisome but not the elongasome organizes capsule synthesis in Streptococcus pneumoniae
The bacterial cell envelope consists of multiple layers, including the peptidoglycan cell wall, one or two membranes, and often an external layer...
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Re-evaluation of Streptococcus pneumoniae carriage in Portuguese elderly by qPCR increases carriage estimates and unveils an expanded pool of serotypes
Streptococcus pneumoniae (pneumococcus) is a leading cause of infections worldwide. Disease is preceded by asymptomatic colonization of the upper...
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IL-17A expression in the adenoid tissue from children with sleep disordered breathing and its association with pneumococcal carriage
Tonsil and adenoid-tissue hypertrophy (AH) is the most common cause of pediatric sleep-disordered breathing (SDB), with AH possibly initiated by...
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Clearance of mixed biofilms of Streptococcus pneumoniae and methicillin-susceptible/resistant Staphylococcus aureus by antioxidants N-acetyl-l-cysteine and cysteamine
Biofilm-associated infections are of great concern because they are associated with antibiotic resistance and immune evasion. Co-colonization by Staphy...
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Outpacing the pneumococcus: Antibody dynamics in the first few days following pneumococcal capsular antigen stimulation
Children in develo** countries are frequently exposed to the pneumococcus, but few develop invasive pneumococcal disease (IPD). We test the...
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Transformation of nonencapsulated Streptococcus pneumoniae during systemic infection
Streptococcus pneumoniae (pneumococcus) is a principal cause of bacterial middle ear infections, pneumonia, and meningitis. Capsule-targeted...
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Differential IL-17A response to S. pneumoniae in adenoid tissue of children with sleep disordered breathing and otitis media with effusion
Streptococcus pneumonia , one of the major colonizers in nasopharyngeal adenoids, has been the predominant pathogen causing acute otitis media (AOM)...
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Streptococcus suis TrpX is part of a tryptophan uptake system, and its expression is regulated by a T-box regulatory element
Streptococcus suis , a common member of the porcine respiratory microbiota, can cause life-threatening diseases in pigs as well as humans. A previous...
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High HMGB1 levels in sputum are related to pneumococcal bacteraemia but not to disease severity in community-acquired pneumonia
During bacterial infections, damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs) activate immune cells....
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A hospital-based study on etiology and prognosis of bacterial meningitis in adults
Bacterial meningitis is a neurological emergency with high morbidity and mortality. We herein investigated clinical features, etiology, antimicrobial...
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Predominant role of Haemophilus influenzae in the association of conjunctivitis, acute otitis media and acute bacterial paranasal sinusitis in children
Haemophilus influenzae is a predominant pathogen for conjunctivitis, acute otitis media and acute bacterial paranasal sinusitis in children. We...
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Vitamin D3 regulates PM-driven primary human neutrophil inflammatory responses
Recent evidence has demonstrated that both acute and chronic exposure to particulate air pollution are risk factors for respiratory tract infections...
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Within-host microevolution of Streptococcus pneumoniae is rapid and adaptive during natural colonisation
Genomic evolution, transmission and pathogenesis of Streptococcus pneumoniae , an opportunistic human-adapted pathogen, is driven principally by...
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The profile of microorganisms that associate with acute tonsillitis in children and their antibiotics sensitivity pattern in Nigeria
Acute tonsillitis remains one of the common childhood diseases in develo** countries. Prompt and appropriate treatment based on the knowledge of...
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Longitudinal characterization of nasopharyngeal colonization with Streptococcus pneumoniae in a South African birth cohort post 13-valent pneumococcal conjugate vaccine implementation
Monitoring changes in pneumococcal carriage is key to understanding vaccination-induced shifts in the ecology of carriage and impact on health. We...
