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Diagnostic value of procalcitonin, C-reactive protein and lactate dehydrogenase in paediatric malignant solid tumour concurrent with infection and tumour progression
Infection is a fatal complication in cancer patients that sometimes is not distinguished from tumour progression. We compared the diagnostic value of...
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A pediatric brain tumor atlas of genes deregulated by somatic genomic rearrangement
The global impact of somatic structural variants (SSVs) on gene expression in pediatric brain tumors has not been thoroughly characterised. Here,...
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Antileukemic activity of novel adenosine derivatives
The present study investigated the effect of cladribine (CLA) and six of its derivatives containing a formamidine group at position 6 (CLA-FDM,...
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Episodes of fever in neutropenia in pediatric patients with cancer in Bern, Switzerland, 1993–2012
Fever in neutropenia (FN) is the most frequent potentially life threatening complication of chemotherapy for cancer. Prediction of the risk to...
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Langerhans-cell histiocytosis (LCH) a presentation of two siblings with two different entities
Langerhans cell histiocytosis (LCH) as a term encompasses eosinophilic granuloma and two clinical syndromes: Letterer–Siwe disease and...
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A serum microRNA classifier for the diagnosis of sarcomas of various histological subtypes
Due to their rarity and diversity, sarcomas are difficult to diagnose. Consequently, there is an urgent demand for a novel diagnostic test for these...
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Somatic activating mutations in MAP2K1 cause melorheostosis
Melorheostosis is a sporadic disease of uncertain etiology characterized by asymmetric bone overgrowth and functional impairment. Using whole exome...
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A somatic mutation in erythro-myeloid progenitors causes neurodegenerative disease
The pathophysiology of neurodegenerative diseases is poorly understood and there are few therapeutic options. Neurodegenerative diseases are...
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Combined activation of MAP kinase pathway and β-catenin signaling cause deep penetrating nevi
Deep penetrating nevus (DPN) is characterized by enlarged, pigmented melanocytes that extend through the dermis. DPN can be difficult to distinguish...
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Soluble CD59 is a Novel Biomarker for the Prediction of Obstructive Chronic Lung Allograft Dysfunction After Lung Transplantation
CD59 is a complement regulatory protein that inhibits membrane attack complex formation. A soluble form of CD59 (sCD59) is present in various body...
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Evolutionary features of thyroid cancer in patients with thyroidectomies from 2008 to 2013 in China
To evaluate the characteristics of thyroid carcinoma over time, we carried out a retrospective study to illustrate the evolutionary features of...
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Multicentric reticulohistiocytosis (MRH): case report with review of literature between 1991 and 2014 with in depth analysis of various treatment regimens and outcomes
Multicentric reticulohistiocytosis is a rare disease affecting skin and joints primarily and rarely other organs. We present a case report of this...
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Miscellaneous Impairments
Examination of the eyes can yield valuable information for the diagnosis of systemic disease and sometimes, as in the case of a corneal arcus...
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Respiratory Disorders
Lung disorders are common in the general population. Chronic bronchitis affects 10–25% of the USA population, asthma 5%, and emphysema about 3%. In...
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Dendritic cells and the control of immunity
B and T lymphocytes are the mediators of immunity, but their function is under the control of dendritic cells. Dendritic cells in the periphery...
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Epidermal Langerhans cells bear Fc and C3 receptors
THE mammalian epidermis contains a system of dendritic cells, eponymously referred to as Langerhans cells, whose functions are obscure. It is,...