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High levels of unintegrated HIV-1 DNA in brain tissue of AIDS dementia patients
IN the host cell, retro viral DNAs exist in three main forms: unintegrated linear, unintegrated circular, and integrated (the provirus) 1 . High levels...
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An important international event in 1926: the Dental Congress in Philadelphia
Up to the end of the first quarter of the twentieth century, there existed practically no opportunity for intercontinental relations in the...
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The Fate of Anutrients in the Body
Mammals have developed defence mechanisms that render them capable of metabolising and subsequently excreting a wide range of anutrients. Most drugs...
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The Clinical Problem
The relief of human suffering and the intellectual challenge of a problem almost unrivalled in breadth and depth are the two major yet distinct...
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Prealbumin II: Vitamin A(Retinol)-Binding Protein
Vitamin A circulates in the blood in the form of the alcohol called retinol. Retinol is found bound to prealbumin on electrophoresis.(1) It was soon...
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Vitamin A and Retinol Binding Protein Alterations in Disease
A lipid-soluble compound which is essential for life and present in egg yolk, was first described by Stepp (1909). A similar compound was later found...
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Transferrin: Iron Metabolism
By their very nature all plasma proteins will tend to bind anions and cations and various types of organic compounds. Almost every type of bond,...
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Clinical Significance of Riboflavin Deficiency
The clinical consequences of riboflavin deficiency in humans were first described by Sebrell and Butler (1938). On a diet which furnished only 0.5 mg...
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Trace Metals in Health and Disease
Trace elements often have a bimodal or even a trimodal effect. Severe deficiency of certain trace metals can result in death or severe crippling of...
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Derangements of Biosynthesis, Production and Secretion of Mucus in Gastrointestinal Injury and Disease
The derangements in production and secretion of gastric mucus consist of:...
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Nutritional Deficiencies and Excesses
Dietary derangement as an agent of teratogenesis has special significance in the history of teratology. The production of congenital anomalies by...
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Co-carcinogenic Effect of Progesterone on 20-Methylcholan-threne Induced Cervical Carcinoma in Mice
THE secretion of mucosubstances in the genital tract seems to be related to the ovarian output. It is well known that ambivalent cells of the vaginal...
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Galactose Metabolism : Phenotypic Differences among Tissues of a Patient with Congenital Galactosæmia
IT has recently been reported that two patients who had the characteristic syndrome of congenital galactosæmia as infants, and who lack gal-1-P...
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Metaplasia of Aortic Connective Tissue to Cartilage and Bone induced by the Intravenous Injection of Papain
THE effect of intravenous papain on the cartilage matrix has been reported by L. Thomas 1 . Recently we have been investigating the acute lipæmia...
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Mycophenolic Acid: an Anti-cancer Compound with Unusual Properties
MYCOPHENOLIC acid (UK patent applications 43131/66 and 43132/66) emerged as a potential anti-cancer compound during routine screening tests with...
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Induction of Lung Tumours by Radioactive Particles
INHALATION provides one of the most accessible routes for the entry of radioactive materials into the body. To evaluate the health hazards of...