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Behavioral Despair and Home-Cage Activity in Mice with Chronically Elevated Baseline Corticosterone Concentrations
Dysfunction of the hypothalamic-pituitary-adrenal axis resulting in elevated baseline glucocorticoid concentrations is a hallmark of stress-related...
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Reduced Oral Ethanol Avoidance in Mice Lacking Transient Receptor Potential Channel Vanilloid Receptor 1
Ethanol is a known oral trigeminal stimulant and recent data indicate that these effects are mediated in part by transient receptor potential channel...
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Rapid Selection Response for Contextual Fear Conditioning in a Cross Between C57BL/6J and A/J: Behavioral, QTL and Gene Expression Analysis
We used short-term selection to produce outbred mouse lines with differences in contextual fear conditioning. Within two generations of selection all...
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Aggressive and Mating Behaviors in Two Types of Sex Reversed Mice: XY Females and XX Males
Aggressive and mating behaviors were assessed in XX females, XY females, and XY males of the C57BL/6/J/Ei (“C57BL/6” or “B6”) strain of mouse. The Y...
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Intrauterine Position Effects on Anogenital Distance and Digit Ratio in Male and Female Mice
Anogenital distance (AGD) and the ratio of the second (index) to fourth (ring) digit lengths (2D:4D) are two widely used indicators of prenatal...
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Divergent Physical Activity and Novel Alternative Responses to High Fat Feeding in Polygenic Fat and Lean Mice
We determined whether altered physical activity levels might underlie the contrasting adiposity of a divergently selected polygenic murine model of...
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Genetic and Structural Analysis of the Basolateral Amygdala Complex in BXD Recombinant Inbred Mice
The amygdala integrates and coordinates emotional and autonomic responses. The genetics that underlie variation in amygdala structure may be coupled...
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Sweet and Bitter Taste of Ethanol in C57BL/6J and DBA2/J Mouse Strains
Studies of inbred strains of rats and mice have suggested a positive association between strain variations in sweet taste and ethanol intake....
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Feeling Strained? Influence of Genetic Background on Depression-Related Behavior in Mice: A Review
Depression is a growing pandemic in developed societies. The use of inbred mouse strains in pre-clinical psychiatric research has proven to be a...
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Plaques, Tangles, and Memory Loss in Mouse Models of Neurodegeneration
Within the past decade, our understanding of the pathogenic mechanisms in Alzheimer’s disease (AD) has dramatically advanced because of the...
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Effects of Genetic and Procedural Variation on Measurement of Alcohol Sensitivity in Mouse Inbred Strains
Mice from eight inbred strains were studied for their acute sensitivity to ethanol as indexed by the degree of hypothermia (HT), indexed as the...
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In vivo Characterization of Brain Morphometric and Metabolic Endophenotypes in Three Inbred Strains of Mice Using Magnetic Resonance Techniques
C57BL/6J, FVB/N and 129/SvJ mice are commonly used as background strains to engineer genetic models of brain pathologies and psychiatric disorders....
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Strain Differences in Rewarded Discrimination Learning Using the Olfactory Tubing Maze
We trained BALB/c Byllco (C), CD-1, SV 129/SvPasCr1 (129 SV), C57BL/6 (B6) and DBA/2J (D2) mice using the olfactory tubing maze with the hope of...
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Intravenous Drug Self-administration in Mice: Practical Considerations
Chronic intravenous drug self-administration in rodents is a useful procedure for predicting the abuse liability of novel drugs in humans, for...
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A Method for Analyzing Strain Differences in Acquisition of IV Cocaine Self-administration in Mice
The techniques currently available for studying drug self-administration in animals offer the unique opportunity to carry out micro-analysis of...
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Identification of QTLs Influencing Alcohol Preference in the High Alcohol Preferring (HAP) and Low Alcohol Preferring (LAP) Mouse Lines
The High- and Low-Alcohol Preferring (HAP1/LAP1 and HAP2/LAP2) mouse lines were developed by selective breeding for differences in alcohol...
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Animal Models Relevant to Schizophrenia and Autism: Validity and Limitations
Development of animal models is a crucial issue in biological psychiatry. Animal models provide the opportunity to decipher the relationships between...
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Genetics of Dopamine and its Contribution to Cocaine Addiction
Cocaine addiction is a major health and social problem for which there are presently no effective pharmacotherapies. Many of the most promising...
