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Human germline editing in the era of CRISPR-Cas: risk and uncertainty, inter-generational responsibility, therapeutic legitimacy
BackgroundClustered Regularly Interspaced Short Palindromic Repeats-associated (CRISPR-Cas) technology may allow for efficient and highly targeted...
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CRISPR-Cas and the Wicked Problem of Moral Responsibility
The emergence of CRISPR-Cas genome editing has raised severe ethical concerns. It has been suggested that CRISPR-Cas leads to a game-changing shift...
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CRISPR-Cas changing biology?
Eugene V. Koonin argues that fundamental research of CRISPR-Cas mechanisms has (among other things) illuminated “fundamental principles of genome...
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Map** the ‘Ethical’ Controversy of Human Heritable Genome Editing: a Multidisciplinary Approach
Genome editing, for instance by CRISPR-Cas, is a major advancement of the last 10 years in medicine but questions ethically our practices. In...
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Lamarckian realities: the CRISPR-Cas system and beyond
In his target article, Koonin discusses the insights into the evolution of bacterial genomes provided by the CRISPR-Cas system. This evolved defense...
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CRISPR-Cas immunity: beyond nonself and defence
In this commentary of Koonin’s target paper, we defend an extended view of CRISPR-Cas immunity by arguing that CRISPR-Cas includes, but cannot be...
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Striving for clarity about the “Lamarckian” nature of CRISPR-Cas systems
Koonin argues that CRISPR-Cas systems present the best-known case in point for Lamarckian evolution because they satisfy his proposed criteria for...
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Mutationism, not Lamarckism, captures the novelty of CRISPR–Cas
Koonin, in an article in this issue, claims that CRISPR–Cas systems are mechanisms for the inheritance of acquired adaptive characteristics, and that...
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Homo technologicus Menschenbilder in den Technikwissenschaften des 21. Jahrhunderts
Der weit verbreitete Einsatz von Technologie fördert in der gegenwärtigen digitalen Gesellschaft transhumanistische Tendenzen. Durch das Aufkommen...
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Gentherapie
Die ethische Diskussion über die GentherapieGentherapie war über die Zeit deutlichen Veränderungen unterworfen. Anfangs wurde vor allem die...
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Learning from Icarus: The Impact of CRISPR on Gene Editing Ethics
After centuries of crude genetic engineering through crossbreeding, the ability to directly intervene in life’s fundamental blueprint led to...
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Good Reasons to Avoid Germline Intervention: A Response to Sahotra Sarkar
This essay takes issue with the statement by the biologist and philosopher Sahotra Sarkar in his recent book Cut-and-Paste Genetics: A CRISPR...
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Bioethical Decision-Making About Somatic Cell Genome Editing: Sickle-Cell Disease as a Case Study
Somatic cell genome editing (SCGE) now allows exquisitely precise and targeted non-heritable changes to be made to human DNA. While SCGE has many...
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Plastic Ontogenesis: Memory, Closure, and Habitual Teleology in Development
The aim of this chapter is to shed some light on the fascinating interplay between agency and memory in biological systems and to explore how these...
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Jean Gayon, History and Philosophy of Biology: A New Synthesis
In this contribution, I show that Jean Gayon’s work operates an original synthesis between the history of scienceHistory of science, the philosophy...
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Bioeconomy and Genome Editing: A Comparison Between Germany and the Netherlands
This chapter examines the extent to which strategies for bioeconomic transformation have been developed in Germany and the Netherlands and how they...
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Ethical Issues in Genetically Modified Foods: From Transgenesis to CRISPR-Cas9 Genome Editing Technology
Traditional ethical quandaries related to GM foods have been addressed profusely throughout the years. Still, some concerns remain regarding...