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Using Polysorbates to Create Parenteral Dosage Forms of Hydrophobic Substances (A Review)
Low solubility of drugs is a constantly encountered problem for pharmaceutical science in the field of parenteral dosage form development. This...
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Quantitative Investigation on Exposure to Potentially Harmful Excipients by Injection Drug Administration in Children Under 2 Years of Age and Analysis of Association with Adverse Events: A Single-Center, Retrospective Observational Study
IntroductionPotentially harmful excipients (PHEs) for children have been reported and the need for information collection has been advocated....
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Use of Surfactants in Quality Control of Solid Dosage Forms with Respect to Microbiological Indicators
The present study focuses on the use of surfactants (SA) in quality control of solid dosage forms. Features of the dissolution of solid dosage forms...
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Development of a Quantitative Determination Method for Polysorbate 80 in Biologicals by Size-Exclusion High-Performance Liquid Chromatography
Aquantitative determination method for polysorbate 80 in biological medicinal preparations using size-exclusion chromatography with UV detection was...
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Formulation Design for Freeze-Drying: Case Studies of Stabilization of Proteins
Formulation design is an integral part of drug product development for parenterally applied dosage forms. In particular for freeze-dried...
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Hot Melt Extrusion Technology as a Modern Strategy for Improving the Bioavailability of Flavonoids
The pharmacological activity of flavonoids as potential candidates for the development of drugs based on biologically active substances of plant...
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Permeability Enhancers in Transdermal Delivery System Technology (Review)
Transdermal delivery of drugs is a current alternative route of administration for systemic actions because of a whole series of unarguable...
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Sustainability in Drug and Nanoparticle Processing
The formulation of drugs in poly(lactic-co-glycolic acid) (PLGA) nanoparticles can be accomplished by various methods, with nanoprecipitation and...
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Concepts and Strategies in the Design of Formulations for Freeze Drying
In order to enhance the storage stability of water labile molecules the common practice is to employ lyophilization (freeze drying) process to create...
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Overview of Freeze Drying
Freeze drying which is also termed as lyophilization is one of the drying technologies that is commonly used to enhance the storage stability of...
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Raw Materials
Raw materials for pharmaceutical preparations are either active substances (or active pharmaceutical ingredients (APIs)) or excipients. The choice of...
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Physical Chemistry
Many pharmaceutical dosage forms are liquids or semi-liquids such as solutions, colloidal systems, suspensions and emulsions. This chapter deals with...
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Parenteral
This chapter gives an overview of parenteral dosage forms and the rationale for their use. Parenterals are sterile preparations that are injected...
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Albumin nanoscience: homing nanotechnology enabling targeted drug delivery and therapy
Albumin is a biocompatible, non-immunogenic and versatile drug carrier system. It has been widely used to extend the half-life, enhance stability,...
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Interchangeability Criteria for Levofloxacin-Based Medicinal Products in the Russian Federation
The present research was aimed at finding informative criteria for regulating the procedure to determine the interchangeability of systemic...
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Nanostructured lipid carriers: A potential use for skin drug delivery systems
Skin application of pharmaceutical products is one of the methods used for drug administration. The problem of limited drug penetration via topical...
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Raw Materials
Raw materials for pharmaceutical preparations are either active substances (or active pharmaceutical ingredients: APIs) or excipients. The choice of...
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Physical Chemistry
Many pharmaceutical dosage forms are liquids or semi-liquids such as solutions, colloidal systems, suspensions and emulsions. This chapter deals with...
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Validation and Control of Bioanalytical Methods
The results of toxicokinetic, pharmacokinetic, and bioequivalence studies are used to make critical decisions regarding the safety and efficacy of...
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Analytical methods and formulation factors to enhance protein stability in solution
Development of stable protein formulations needs intimate knowledge of the proteins’ physicochemical properties. More specifically, understanding the...