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Determination of Paclitaxel Solubility and Stability in the Presence of Injectable Excipients
Due to poor aqueous solubility of paclitaxel, cremophor is one of the excipients used to improve solubility in Taxol while it is responsible for a...
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Bruceine D Sensitizes Human Ovarian Cancer Cells to Paclitaxel Through JNK and STAT3 Signal Regulation
Exploring novel regimens is essential to ensure the efficacy of paclitaxel-based chemotherapy in epithelial ovarian cancer. Brucea javanica (L.)...
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Cannabidiol and mitragynine exhibit differential interactive effects in the attenuation of paclitaxel-induced mechanical allodynia, acute antinociception, and schedule-controlled responding in mice
BackgroundFor many chemotherapy patients peripheral neuropathy is a debilitating side effect. Mitragyna speciosa (kratom) contains the alkaloid...
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Additive pharmacological interaction between sirtuin inhibitor cambinol and paclitaxel in MCF7 luminal and MDA-MB-231 triple-negative breast cancer cells
BackgroundBreast cancer (BC) is the most common malignancy and the leading cause of cancer-related death in women worldwide. Sirtuin inhibitors...
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Validation of a UV-Spectrophotometric Method for Quantitative Determination of Paclitaxel in a Targeted Delivery System Based on Poly(Lactic–Glycolic Acid) Copolymer Nanoparticles
A UV spectrophotometric method for quantitative determination of paclitaxel in a conjugate of poly(lactic-glycolic acid) (PLGA) copolymer...
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Preparation, Characterization, and In-Vitro Assessment of Calixarene Nanovesicles: A Supramolecular Based Nano-Carrier for Paclitaxel Drug Delivery
In drug development field, active substance solubilization is among most important factors. Expanding significance is set on the role of drug...
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Hyperthermal paclitaxel-bound albumin nanoparticles co-loaded with indocyanine green and hyaluronidase for treating pancreatic cancers
Albumin nanoparticles have become an attractive cancer nanomedicine platform due to their pharmaceutical advantages. Recently, photothermal therapy...
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Application of magnetic solid-phase extraction for sensitive determination of anticancer drugs in urine by means of diamino benzidine tetrachlorohydrate modified magnetic nanoparticles
BackgroundThe analysis of drug active molecules and residues in the treatment of cancer is important for the sustainability of human life and...
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AM1172 (a hydrolysis-resistant endocannabinoid analog that inhibits anandamide cellular uptake) reduces the viability of the various melanoma cells, but it exerts significant cytotoxic effects on healthy cells: an in vitro study based on isobolographic analysis
BackgroundDespite great advances in our understanding of the impact of cannabinoids on human organism, many of their properties still remain...
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Differential effect of LPS and paclitaxel on microglial functional phenotypes and circulating cytokines: the possible role of CX3CR1 and IL-4/10 in blocking persistent inflammation
Neuroinflammation plays a role in cancer chemotherapy-induced chronic pain. Thus far, most studies have focused on neuroinflammation suppression....
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Novel method of measurement of in vitro drug uptake in OATP1B3 overexpressing cells in the presence of dextran
BackgroundIn predictions about hepatic clearance (CL H ), a number of studies explored the role of albumin and transporters in drug uptake by liver...
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Cytotoxic and Apoptosis-Inducing Activities of Iridium Complexes Bearing 2-Phenylimidazo[4,5-f][1,10]-Phenanthroline Derivatives in Human Cancer Cells
In recent years, there has been growing exploration of organometallic transition metal complexes as promising options for develo** anticancer...
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Combination therapy involving HSP90 inhibitors for combating cancer: an overview of clinical and preclinical progress
The molecular chaperone heat shock protein 90 (HSP90) regulates multiple crucial signalling pathways in cancer by driving the maturation of key...
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PLANT BIOTECHNOLOGY
Extensive research is underway worldwide on the production of active plant components from medicinal plants under controlled, reproducible conditions...
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Agonisten und Antagonisten für nucleäre Rezeptoren
Bei aller Begeisterung über die Erfolge beim strukturbasierten Entwurf von Enzyminhibitoren darf nicht übersehen werden, dass weniger als die Hälfte...
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Targeted Molecular Therapeutics for Pulmonary Diseases: Addressing the Need for Precise Drug Delivery
Respiratory diseases are a major concern in public health, impacting a large population worldwide. Despite the availability of therapies that...
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Sensitivity Analysis for Restricted Mean Survival Time When Survival Curves Have Divergent Tails
New immunotherapy methods are being developed to provide cancer patients with survival benefit. The tail effect of immuno-oncology (IO) therapy...
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Mirvetuximab soravtansine in folate receptor alpha-positive, platinum-resistant ovarian cancers: a profile of its use
Mirvetuximab soravtansine (Elahere TM ), an antibody-drug conjugate carrying a maytansinoid payload targeting folate receptor alpha (FRα), is a...
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Anti-angiogenesis revisited: resha** the treatment landscape of advanced non-small cell lung cancer
Although anti-angiogenic agents have been of limited use in the treatment of non-small cell lung cancer (NSCLC) until recently, further roles for the...
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Creation of a Model of a Complex Delivery Nanosystem Containing a Tyrosine Kinase Inhibitor and a Photosensitizer
The aim of this work was to construct complex delivery systems for the well-known hydrophobic inhibitor of tyrosine kinases, Gefitinib, and the...
