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Comparative evaluation of bioactive phytochemicals in Spinacia oleracea cultivated under greenhouse and open field conditions
Various factors related to growing conditions can influence the nutritional quality of plants, including vegetable crops, especially the contents of...
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Effects of chronic delta-opioid receptor agonist on the excitability of hippocampal glutamate and brainstem monoamine neurons, anxiety, locomotion, and habituation in rats
BackgroundShort-term treatment with non-peptide agonists of delta-opioid receptors, such as agonist SNC80, induced behavioral effects in rodents,...
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Effect of Thioxypine and Its Components on Behavioral Despair in Potential Antidepressant Screening Tests
The effect of thioxypine (2-ethyl-6-methylpyridinol-3-yl thioctate) and its acyl and alcohol components on the duration of behavioral despair (BD) in...
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Uliginosin B, a Natural Phloroglucinol, Increases Hippocampal GSH, MCP-1 and IL-10 Levels in Mice
The activation of immuno-inflammatory pathways and oxidative/nitrosative stress results in behavioral, neurochemical, and neuroendocrine...
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Cordia dichotoma Fruits Aqueous Extracts Alleviates Depressive-Like Behavior in a Rat Model via Regulating Serotonergic Neurotransmitters
Depression is a common mental illness caused by the interaction of social, psychological, and physical factors. The number of people suffering from...
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Tryptamine Analogs as Antidepressant and Anxiolytic Agents: Synthesis and In Vivo Evaluation
A series of tryptamine derivatives were synthesized by targeting amine of tryptamine side chain with various substituted/unsubstituted phenacyl,...
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Ameliorative Effects of Alkaloids from Narcissus cv. Hawera: Behavioral Changes Following Acute and Accelerated Chronic Restraint Stress
The adverse effects of stress explain the increased demand for phytochemical and biochemical pharmacological agents with potential adaptogenic...
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Medication supply chain resilience during disasters: exploration of causes, strategies, and consequences applying Strauss and Corbin's approach to the grounded theory
BackgroundDue to the importance of procurement of medicines and medical supplies during disasters and the significance of an existing resilient...
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Crocin Administration Represses Depressive-Like Behaviors in Rats by Targeting the Hippocampal miRNA-99A/FKBP51/PSD-95 Level
We investigated the role of miR-99a in regulating depressant activity by administering crocin in an animal model of chronic unpredictable mild stress...
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An Innovative Stress-Protective and Detoxification Substance for Reducing the Central Nervous System Effects of Alcohol Intoxication
The search for new drugs to reduce the toxic effects of alcohol on the body is based on the creation of various pharmaceutical agents that affect the...
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Vortioxetine liposomes as a novel alternative to improve drug stability under stress conditions: toxicity studies and evaluation of antidepressant-like effect
BackgroundVortioxetine hydrobromide (VXT), a new therapeutic option in the treatment of major depressive disorder, is a poorly soluble drug, and...
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Nootropic Effects of 7-Isoprenyloxycoumarin and Herniarin from Tagetes lucida on Lipopolysaccharide-Induced Neuroinflammation
Tagetes lucida Cav., Asteraceae, is an essential cultural plant that is traditionally used to treat diseases involving inflammatory processes and is...
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Design, Characterization and Optimization of Solid Lipid Nanoparticles of Bupropion by Using 23 Factorial Design
Nanotechnology is emerging as a field in medicine that is expected to elicit significant therapeutic benefits. The main objective of the present...
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Synthesis and Antidepressant Activity of 5-Amine-Substituted 3-Bromo-1-(1,1-Dioxothietan-3-yl)-4-Nitro-1H-Pyrazoles
5-Amino-substituted 3-bromo-1-(1,1-dioxothietan-3-yl)-4-nitro-1 H -pyrazoles were synthesized via the reactions of...
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Investigating the potential effects of α-synuclein aggregation on susceptibility to chronic stress in a mouse Parkinson’s disease model
BackgroundParkinson’s disease (PD) is a motor disorder characterized by the degeneration of dopaminergic neurons, putatively due to the accumulation...
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Prenatal MAM exposure raises kynurenic acid levels in the prefrontal cortex of adult rats
BackgroundElevated brain levels of kynurenic acid (KYNA), a metabolite in the kynurenine pathway, are associated with cognitive dysfunctions, which...
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Synthesis and Anxiolytic Activity of 9-(4-Ethylpiperazino-1-Carbonyl)Fluoren-9-OL Hydrochloride, A Structural Analog of the M-Choline Blocker Amizil
Experiments on rats in a depressive-like state model caused by reserpine employed the elevated plus-maze and open-field tests and showed that...
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Effect of atomoxetine on ADHD-pain hypersensitization comorbidity in 6-OHDA lesioned mice
BackgroundMethylphenidate and atomoxetine are used for the treatment of attention-deficit/hyperactivity disorder (ADHD). Our previous studies...
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L-proline transporter inhibitor (LQFM215) promotes neuroprotection in ischemic stroke
BackgroundL-proline transporter (PROT/SLC6A7) is closely associated with glutamatergic neurotransmission, where L-proline modulates the NMDA receptor...
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Reformative Effect of Daidzein on Motor Dysfunction Following Rotenone Injection in Ovariectomized Rats
Parkinson’sdisease is a neurodegenerative disorder manifested by progressive damage of dopaminergic neurons of the substantia nigra pars compacta...
