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Paeoniflorin increases the survival of Pseudomonas aeruginosa infected Caenorhabditis elegans at the immunosuppression stage by activating PMK-1, BAR-1, and EGL-1 signals
Paeoniflorin is the major active compound of total glycoside of paeony in Paeonia lactiflora Pall. Although several aspects of beneficial effects of...
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Treating paediatric Crohn’s disease is challenging but new treatments hold promise
Paediatric Crohn’s disease is associated with a high disease burden and greater requirement for immunosuppression compared with adult-onset disease....
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The Warburg effect: a score for many instruments in the concert of cancer and cancer niche cells
Although Warburg's discovery of intensive glucose uptake by tumors, followed by lactate fermentation in oxygen presence of oxygen was made a century...
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Influence of Urolithin a on Cytokine Production by Various Cancer Cell Lines
Urolithin A is a polyphenolic metabolite of ellagic acid and ellagitannins that is produced by the intestinal microbiota and has a higher...
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Myriocin suppresses tumor growth by modulating macrophage polarization and function through the PI3K/Akt/mTOR pathway
Macrophages within the tumor microenvironment (TME), referred to as tumor-associated macrophages (TAMs), are involved in various aspects of tumor...
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How do phosphodiesterase-5 inhibitors affect cancer? A focus on glioblastoma multiforme
Since the discovery of phosphodiesterase-5 (PDE5) enzyme overexpression in the central nervous system (CNS) malignancies, investigations have...
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Synthesis and Immunotropic Activity of New Quinazoline Derivatives in Mice
New condensed pyrimidine compounds with a benzoannelated quinazoline structure and various functional substituents at the pyrimidine N3-position were...
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The multifaceted role of STAT3 pathway and its implication as a potential therapeutic target in oral cancer
Oral cancer is one of the leading causes of cancer-related deaths, and it has become a matter of serious concern due to the alarming rise in its...
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The Prospects of 5-Androstenediol and its Synthetic Derivatives as Novel Radioprotective Drugs
The steroid hormone 5-androstenediol (5-AED) has been advanced as a possible countermeasure for protection from ionizing radiation. It is highly...
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Nanomedicine – Immune System Interactions: Limitations and Opportunities for the Treatment of Cancer
Nanoparticles interact with immune cells in many different ways. These interactions are crucially important for determining nanoparticles’ ability to...
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Study of the Photoprotector Activity of Melanin Gel in an Ultraviolet Erythema Model in Rats
Results from a study of the photoprotective effect of a melanin-based gel using an ultraviolet erythema model in rats are presented. Use of gels...
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Crosstalk between angiogenesis and immune regulation in the tumor microenvironment
Cancer creates a complex tumor microenvironment (TME) composed of immune cells, stromal cells, blood vessels, and various other cellular and...
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Astragalus polysaccharide: a review of its immunomodulatory effect
The Astragalus polysaccharide is an important bioactive component derived from the dry root of Astragalus membranaceus . This review aims to provide a...
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Function and therapeutic development of exosomes for cancer therapy
Exosomes are extracellular vesicles, 50–150 nm in diameter, released by most cells. Exosomes contain several intracellular components, including DNA,...
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Manage seborrhoeic dermatitis in older adults with customised regimens that address age-related factors
Although seborrhoeic dermatitis can develop in people of all ages, it is especially common in older adults and severely impairs quality of life....
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Manage truncal acne and scarring the same as for facial acne, but more trunk-specific therapies are warranted
Truncal acne is present in a significant proportion of patients with acne vulgaris, and impacts patients differently to facial acne. However, there...
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Calycosin Alleviates Lupus Nephritis by Activating the Nrf2/HO-1 Signaling Pathway
Lupus nephritis is a serious condition, for which treatments are limited; hence, there is a need for new cure approaches. The aim of this study was...
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Be wary of adverse events when considering pharmacotherapies for spine-related pain in elderly patients
Take care when considering pharmacotherapy for spine-related pain in elderly patients as drug-related adverse events are more likely to occur and to...
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Liposomal form of Dexamethasone in Experimental Autoimmune Uveitis: Clinical and Immunological Effects
The effectiveness of liposomal dexamethasone in experimental autoimmune uveitis in rabbits was studied. An original liposomal form of dexamethasone...
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Opioid misuse in older patients requires careful consideration of many factors
There is insufficient clinical data on how to optimally treat and manage opioid misuse in older patients. Opioid use affects older adults differently...