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Using Polysorbates to Create Parenteral Dosage Forms of Hydrophobic Substances (A Review)
Low solubility of drugs is a constantly encountered problem for pharmaceutical science in the field of parenteral dosage form development. This...
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Creation of a Model of a Complex Delivery Nanosystem Containing a Tyrosine Kinase Inhibitor and a Photosensitizer
The aim of this work was to construct complex delivery systems for the well-known hydrophobic inhibitor of tyrosine kinases, Gefitinib, and the...
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Trypsin Immobilization on Poly(N-Vinylcaprolactam) and Its Copolymers with N-Vinylimidazole
Poly( N -vinylcaprolactam) and its copolymers with N -vinylimidazole were studied as carriers for trypsin immobilization. Trypsin immobilization on poly(
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Dermal
Preparations for cutaneous (or dermal) application may be used for local treatment as well as for transdermal administration with a systemic effect....
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IN SILICO and IN VITRO Estimation of MAO-B Inhibitory Activity of Newly Synthesized Hydrazones Bearing a Pyrrole Heterocyclic System
This paper is focused on the in silico and in vitro determination of MAO-B inhibitory activity on recombinant MAO-B enzyme ( h MAOB) of newly...
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Raw Materials
Raw materials for pharmaceutical preparations are either active substances (or active pharmaceutical ingredients (APIs)) or excipients. The choice of...
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Outflow Kinetics of Chemical Solutions from Hydrophobized Nanostructural Silicon Compounds: Effect of Surface Tension
The outflow kinetics of aqueous solutions of n -propanol as model liquids (drug solutions) from hydrophobic nanoporous silica gel 60 C 8 was studied....
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Technology for Obtaining Ecdisten Substance from the Aerial Part of Silene praemixta
The optimum parameters influencing the extraction of ecdisten substance (ecdysterone) from the aerial part of Silene praemixta M. Pop. were found....
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Nose
This chapter deals with preparations for nasal administration, with a local or a systemic effect. Classical nasal preparations were always associated...
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Hot Melt Extrusion Technology as a Modern Strategy for Improving the Bioavailability of Flavonoids
The pharmacological activity of flavonoids as potential candidates for the development of drugs based on biologically active substances of plant...
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Oropharynx
Preparations for the oropharynx form a wide range, from the classical gargles and lozenges up to modern muco-adhesive forms, based on polymer...
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Physical Chemistry
Many pharmaceutical dosage forms are liquids or semi-liquids such as solutions, colloidal systems, suspensions and emulsions. This chapter deals with...
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Progress in Ocular Drug Delivery: Challenges and Constraints
The eye has several dynamic and static barriers in place to limit the entry of foreign substances including therapeutics. As such, efficient drug...
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Determination of Paclitaxel Solubility and Stability in the Presence of Injectable Excipients
Due to poor aqueous solubility of paclitaxel, cremophor is one of the excipients used to improve solubility in Taxol while it is responsible for a...
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Marine Bacteria from the Southeast Coast of Brazil as a Source of Insecticidal Compounds
Vector-borne diseases are public health concerns in equatorial, tropical, and subtropical regions. Controlling their vectors remains the main...
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Recent advances in selective and targeted drug/gene delivery systems using cell-penetrating peptides
Biological cell membranes are a natural barrier for living cells. In the last few decades, the cell membrane has been the main hurdle in the...
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Quantitative Determination of Ubiquinone and Ubiquinol in Blood Plasma by HPLC with Mass-Spectrometric Detection
A method using HPLC with tandem mass spectrometry (HPLC-MS/MS) is proposed and validated for quantitative determination of ubiquinone and ubiquinol...
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Solvent Systems Used in Countercurrent Chromatography for the Purification of Diterpene Compounds
Diterpenes are isoprene-derived compounds, bearing four units of this building block on their fundamental core. The chemical diversity reported for...
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Brazilian Medicinal Plants with Antiamyloidogenic Activity
Amyloid fibrillation is a process involved in a large set of pathologies, including diabetes and Alzheimer’s. Although Brazil has a large...
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Oral Solids
This chapter provides the pharmaceutical basis of common solid dosage forms and discusses biopharmaceutical aspects related to their formulation....