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Preparation and In Vitro/Vivo Evaluation of New Celecoxib Solid Dispersions with Co-Carrier Containing Aerosil and Poloxamer 188
Solid dispersions (SDs) containing co-carrier were developed to improve in vitro dissolution and in vivo pharmacokinetics of celecoxib (CXB). Various...
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Effervescent tablet-assisted deep eutectic solvent based on magnetic nanofluid for liquid phase microextraction of tyrosine kinase inhibitors in plasma samples by high-performance liquid chromatography
BackgroundTyrosine kinase inhibitors (TKIs) are efficient anti-cancer drugs. The analysis of TKIs in the treatment of cancer is important to achieve...
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Pharmacokinetic interaction between regorafenib and atorvastatin in rats
BackgroundRegorafenib is used in the treatment of colorectal cancer and hepatocellular carcinoma. Due to the co-morbidity of hyperlipidemia in these...
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Ternary Solid Dispersion of Celecoxib Produced by the Solvent Method with Improved Solubility and Dissolution Properties
Celecoxib, the first cyclooxygenase-2 selective nonsteroidal anti-inflammatory drug, has a wide range of pharmacological effects, including...
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Hot Melt Extrusion Technology as a Modern Strategy for Improving the Bioavailability of Flavonoids
The pharmacological activity of flavonoids as potential candidates for the development of drugs based on biologically active substances of plant...
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Trypsin Immobilization on Poly(N-Vinylcaprolactam) and Its Copolymers with N-Vinylimidazole
Poly( N -vinylcaprolactam) and its copolymers with N -vinylimidazole were studied as carriers for trypsin immobilization. Trypsin immobilization on poly(
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Pulmonary
For adequate pulmonary drug therapy, choosing the appropriate type of inhaler is just as important as selecting the right type of drug. This chapter...
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Interactions of fentanyl with blood platelets and plasma proteins: platelet sensitivity to prasugrel metabolite is not affected by fentanyl under in vitro conditions
BackgroundClinical trials indicate that fentanyl, like morphine, may impair intestinal absorption and thus decrease the efficacy of oral P2Y 12 ...
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Knowledge-Based Design of Multifunctional Polymeric Nanoparticles
Conventional drug delivery systems (DDS) today still face several drawbacks and obstacles. High total doses of active pharmaceutical ingredients...
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A Double-Edged Sword: Focusing on Potential Drug-to-Drug Interactions of Quercetin
Herbal and herbal dietary supplements have a massive share of the global market, and their use continues to grow worldwide. There is a general...
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Basic Operations
Weighing, volume measuring, particle size reduction, dispersing, dissolving and mixing, including checking each step, are key issues in all...
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Challenges of current treatment and exploring the future prospects of nanoformulations for treatment of atopic dermatitis
Atopic dermatitis (AD) is a predominant and deteriorating chronic inflammation of the skin, categorized by a burning sensation and eczematous lesions...
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Map** Cutaneous Tissue Distribution of Sesquiterpene Lactone Goyazensolide Using MALDI Imaging
Species of Lychnophora , popularly known in Brazil as “arnica-da-serra,” are widely used in topical preparations as analgesics and...
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Stimuli-Responsive Non-viral Nanoparticles for Gene Delivery
Considering nucleic acids as the language of life and the genome as the instruction manual of cells, their targeted modulation promises great...
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Recent Formulation Advances of Mangiferin
Nutraceuticals have recently gained interest owing to their valuable contribution in the treatment of several diseases, with high safety margin and...
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Essential Oil Composition and Antimicrobial Activity of Jacaranda cuspidifolia Leaves
The genus Jacaranda (Bignoniaceae) consists of approximately 50 species, J. cuspidifolia being one member of this genus cultivated all over the...
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Physicochemical and Biopharmaceutical Studies of Solid Dispersions of Cinnarizine
Cinnarizine is an economically affordable drug that belongs to the calcium-channel blocker group and is widely used to treat cerebral diseases. It is...
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Looking to the Future: Drug Delivery and Targeting in the Prophylaxis and Therapy of Severe and Chronic Diseases
High molecular weight actives and cell-based therapy have the potential to revolutionize the prophylaxis and therapy of severe diseases. Yet, the...
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Enhancing solubility and bioavailability of coenzyme Q10: formulation of solid dispersions using Soluplus® as a carrier
Improving the aqueous solubility of poorly soluble compounds have been a major issue in the pharmaceutical industry. In the present study, binary...
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Calycosin Induces Ferroptosis by SLC7A11 Through the PI3K/Akt Pathway in Acute Myelocytic Leukemia
Acute myelocytic leukemia seriously impairs the health and lifespan of patients; thus, effective treatment methods for acute myelocytic leukemia need...
